Abstract:
PURPOSE:To evaluate the efficacy and safety of intravitreal dexamethasone implant in treatment naïve eyes with diabetic macular edema (DME). METHODS:A retrospective analysis of treatment naïve eyes with DME which received intravitreal dexamethasone implant between January 2016 and March 2018 was done. Demographic details of the patients, ocular examination findings at baseline and on follow up visits were noted. Morphological features of DME and central macular thickness were noted on optical coherence tomography at each visit. The details regarding additional treatment for macular edema on follow up were noted. RESULTS:Sixty five eyes were included in the study. The mean age was 59.14 ± 9.59 years. The follow up ranged from 6 to 48 months. Psuedophakic eyes showed visual improvement whereas the phakic eyes showed stable vision. The central foveal thickness showed significant reduction (p = 0.05) in all the eyes. The best corrected visual acuity at final follow up (+0.65 logMAR) was slightly less as compared to baseline (+0.62 logMAR). Retreatment was needed in 37% eyes and antiglaucoma medications in 8% eyes. Cataract progression was noted in 24 eyes (37%); 17 eyes (26.1%) underwent surgery. Notably, 27 eyes (41.5%) had some degree of macular ischemia at baseline. And five eyes (7.7%) showed progression of retinopathy leading to vitreous hemorrhage. CONCLUSION:Dexamethasone implant is helpful in reducing the macular thickness and stabilizing the vision in treatment naïve DME; requiring less number of treatment sessions. However, it does not prevent progression of diabetic retinopathy. The visual improvement may be affected by cataract and macular ischemia.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Ratra D,Sharma U,Dalan Ddoi
10.1177/1120672120949761subject
Has Abstractpub_date
2020-08-10 00:00:00pages
1120672120949761eissn
1120-6721issn
1724-6016pub_type
杂志文章abstract:PURPOSE:To describe a rare case of orbital metastasis from squamous cell carcinoma of the esophagus. METHODS:A 63-year-old man presented with intermittent left-sided headache. This was initially attributed to angle-closure glaucoma and bilateral peripheral laser iridotomies were performed. One month later, he develope...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600316
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abstract:PURPOSE:Transforming growth factor-beta1 (TGF-beta1) is thought to play a pivotal role in the regulation of the wound healing process after glaucoma filtering surgery. The aim of the present study was to investigate whether platelet-derived growth factor isoforms (PDGF-AA, PDGF-BB), basic fibroblast growth factor (bFGF...
journal_title:European journal of ophthalmology
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abstract:PURPOSE:To report the evolution of optic disk noncalcified astrocytic hamartomas in a patient with retinitis pigmentosa throughout 8 years of follow-up. METHODS:Case report. RESULTS:A 42-year-old white man with a diagnosis of retinitis pigmentosa was referred to our medical retinal center for the first time in 2010, ...
journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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journal_title:European journal of ophthalmology
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doi:10.1177/1120672120953339
更新日期:2020-08-27 00:00:00
abstract:PURPOSE:The effect of elevated blood glucose level on the myogenic response of human retinal arterioles to acute increases in blood pressure is investigated. METHODS:The vascular response to raised blood pressure (Bayliss effect) was measured in 12 healthy volunteers by use of the retinal vessel analyzer (RVA). For a ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210501500109
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abstract::S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol/l sodium hydroxide) of the rabbit. The drug was topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations...
journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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doi:10.1177/1120672119832187
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
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更新日期:2003-07-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2008-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2008-03-01 00:00:00
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journal_title:European journal of ophthalmology
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doi:10.5301/EJO.2008.4623
更新日期:2005-01-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900119
更新日期:2009-01-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000511
更新日期:2014-11-06 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120958301
更新日期:2020-09-21 00:00:00
abstract::In myopia patients, Rh and acid phosphatase were typed in two groups: group 1 consisted of 214 patients with low myopia (-6 D or less); group 2 of 124 patients with high myopia (more than -6 D). Statistical analysis of the markers showed a good Hardy-Weinberg equilibrium for both groups. In the Rh system there was a s...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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更新日期:2020-09-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2000-10-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
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更新日期:2015-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
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更新日期:2018-07-01 00:00:00
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journal_title:European journal of ophthalmology
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doi:10.5301/EJO.2008.5031
更新日期:2006-09-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2020-07-24 00:00:00
abstract:PURPOSE:To report a case series of anterior uveitis after Transepithelial Photorefractive Keratectomy (TransPRK) and determine its incidence, demographics and associated clinical features over a study period of 1 year. METHODS:This retrospective case series comprised of 200 eyes (100 patients) which underwent elective...
journal_title:European journal of ophthalmology
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更新日期:2020-11-25 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2010-03-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2013-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00