Abstract:
PURPOSE:To evaluate persistency (time on initial therapy) and the clinical impact of latanoprost versus beta-blocker monotherapy in treating glaucoma. METHODS:This observational, multicenter, retrospective medical chart review study conducted in four European countries included patients with primary open-angle glaucoma or ocular hypertension who began their first glaucoma treatment with latanoprost or a beta-blocker between November 1996 and November 1998. Persistency and glaucoma-related clinical outcomes data were abstracted for the 2 years following treatment initiation. RESULTS:In all, 260 patient charts were analyzed (94 latanoprost, 166 beta-blocker). Patients in the latanoprost group stayed on therapy twice as long as those who received a beta-blocker (p < 0.0001). After adjusting for baseline characteristics, patients receiving a beta-blocker as initial therapy were 3.8 times more likely to change therapy than those initially treated with latanoprost (p < 0.0001). Patients in the latanoprost group also experienced greater mean decreases in intraocular pressure (IOP) than those receiving a beta-blocker (7.4 mmHg versus 4.6 mmHg, respectively; p < 0.0001), and fewer had worsened optic nerve head excavation (1.7% versus 14.2%, respectively; p < 0.05) by the time of their first therapy change or last study visit, whichever came first. CONCLUSIONS:Over a 2-year period, latanoprost was associated with significantly greater persistency and better clinical IOP outcomes compared with beta-blocker therapy.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Diestelhorst M,Schaefer CP,Beusterien KM,Plante KM,Fain JM,Mozaffari E,Dhawan Rdoi
10.1177/112067210301304s03subject
Has Abstractpub_date
2003-07-01 00:00:00pages
S21-9eissn
1120-6721issn
1724-6016journal_volume
13 Suppl 4pub_type
杂志文章,多中心研究abstract:PURPOSE:To investigate whether the central corneal thickness (CCT) shows alterations in Graves disease and Graves ophthalmopathy (GO) cases according to the disease severity and hormonal status of the patients. METHODS:A total of 150 patients (62 male, 88 female) with Graves disease and 32 control subjects (11 male, 2...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.399
更新日期:2008-01-01 00:00:00
abstract::This prospective study of 123 patients undergoing cataract extraction determined the preoperative and surgical factors predisposing to an exaggerated postoperative inflammatory response. It is important to identify the patients at increased risk of complications requiring additional prophylaxis or more intensive posto...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The changes in the cardiovascular system are associated with ocular manifestations, often as a consequence of pathological alteration in the ocular vasculature. The ease of visualization of these retinal changes makes the eye a window to the cardiovascular system. Certain congenital cardiac defects lead to changes in ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672120914232
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To analyze angiographic changes in choroidal neovascular membranes (CNVM) after strontium-plaque (90Sr) irradiation for exudative age-related macular degeneration (AMD) using masked measurement of the CNVM areas and a masked subjective comparison of CNVM size and leakage. METHODS:We studied the baseline, 3, 6,...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.4739
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To investigate the systemic associations of central serous chorioretinopathy (CSCR) with help of clinical and biochemical investigations. DESIGN:Case-control study. PARTICIPANTS:Eighty seven CSCR patients (case) and 82 Asian-Indian patients with primary non-traumatic rhegmatogenous retinal detachment (contr...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120975698
更新日期:2020-11-25 00:00:00
abstract:PURPOSE:Idiopathic sclerosing orbital inflammation (ISOI) has been categorized by some authors as a unique clinicopathologic entity, separate from the heterogeneous group of disorders known collectively as nonspecific orbital inflammation. Histologic similarity and clinical association with other fibrosclerosing condit...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210501500214
更新日期:2005-03-01 00:00:00
abstract:PURPOSE:To assess corneal tissue modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus as well as regeneration of epithelium and subepithelial nerve plexus by in vivo HRT II system confocal microscopy in humans. METHODS:Ten patients with progressive kerat...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600405
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vascul...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672121990576
更新日期:2021-01-26 00:00:00
abstract:PURPOSE:Hand, foot, and mouth disease is a contagious enteroviral infection occurring primarily in children and characterized by vesicular palmoplantar eruptions and erosive stomatitis. There are very few cases of unilateral acute idiopathic maculopathy associated with hand, foot, and mouth infection. We described a ca...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000288
更新日期:2014-01-01 00:00:00
abstract::Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angio...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672118766807
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:To describe the natural course of type 2 idiopathic macular telangiectasia (MT) using spectral-domain optical coherence tomography (SD-OCT). METHODS:Analysis of the different stages of progression of type 2 MT during a period of 3 years using multimodal imaging, including SD-OCT correlated with angiographic an...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000363
更新日期:2013-11-01 00:00:00
abstract::A 60-year-old patient with a history of diabetes mellitus and coronary artery disease was admitted to the eye nose and throat clinic due to complaints of difficulty in breathing. The patient was decided for functional endoscopic sinus surgery with the diagnosis of right nasal polyposis and chronic sinusitis. The patie...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118798570
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To examine whether vitrectomy combined with retinal photocoagulation reduces the vitreous level of vascular endothelial growth factor (VEGF) in patients with macular edema associated with retinal vein occlusion (RVO). METHODS:The authors measured VEGF levels in vitreous samples from four eyes of four patients ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800628
更新日期:2008-11-01 00:00:00
abstract:PURPOSE:Vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8) are angiogenic mediators that share a significant proinflammatory activity. Both substances have been suggested to play a key role in uveitis pathogenesis. The authors analyzed VEGF and IL-8 levels in the aqueous humor and serum of patients with...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700611
更新日期:2007-11-01 00:00:00
abstract:AIM:A multicentre, randomized, placebo-controlled double-masked study was conducted to assess the efficacy and safety of Rimexolone 1% eye drops in reducing inflammation after cataract surgery and intra-ocular lens implantation. METHODS:Rimexolone 1% (124 patients) or placebo (58 patients) was given, four times a day ...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To report on the presence of 4 different structures visualized by confocal microscopy in patients whose clinical presentation suggested infection by Acanthamoeba. METHODS:Data and charts of 28 consecutive patients were analyzed in a retrospective study. Four types of structures were recognized by confocal micr...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000817
更新日期:2017-01-19 00:00:00
abstract:PURPOSE:To compare topographic indices of surface regularity in dry eye patients and in normal subjects (controls) and to investigate the short-term effect of lacrimal punctal plugs on these indices in dry eye patients. METHODS:The surface regularity index (SRI) and surface asymmetry index (SAI) of the TMS-2 corneal t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210101100202
更新日期:2001-04-01 00:00:00
abstract::Electroretinogram (ERG) changes with age have been studied widely, but there is no general agreement about the age at which ERG parameters reach adult values. We studied 296 eyes from 148 healthy subjects, divided into 14 age groups, ranging from 1 week to 21 years. Although most of the maturational changes or ERG tak...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of intracameral Bevacizumab on trabeculectomy success rates. METHODS:A prospective, randomized, interventional clinical trial. Patients with primary open-angle glaucoma were randomly assigned to two groups: trabeculectomy with mitomycin C and trabeculectomy with mitomycin C and intracame...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/1120672119874682
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To report the off-label use of systemic bevacizumab in a patient with stage 3 retinal angiomatous proliferation (RAP) associated with a vascularized pigmented epithelium detachment (PED). METHODS:Interventional case report. RESULTS:The patient was treated with systemic bevacizumab after obtaining fully inform...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700621
更新日期:2007-11-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067210901900317
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To compare glare disability test results in patients with hydrophilic and hydrophobic acrylic intraocular lenses (IOL). METHODS:Sixty eyes of 60 patients were studied in three groups of 20. Each eye in Group 1 had a single-piece hydrophilic acrylic (Bioacryl, Biotech, France) IOL implant, and each eye in Group...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210401400103
更新日期:2004-01-01 00:00:00
abstract:AIMS:To investigate alterations in deep retinal vascular complex (DVC) in patients with non-neovascular intermediate AMD (iAMD), treatment-naïve quiescent macular neovascularization (qMNV), exudative AMD (eAMD) by means of OCT angiography (OCTA). METHODS:Patients with iAMD, qMNV, eAMD and healthy controls presenting i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120968758
更新日期:2020-11-03 00:00:00
abstract::Bruch's membrane, an extracellular matrix located between the retinal pigment epithelium and the choroid, plays a vital role as structural and functional support to the retinal pigment epithelium. Dysfunction of Bruch's membrane in both age-related macular degeneration and other ocular diseases is caused mostly by ext...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
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更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To report a new family belonging to a previously non-investigated geographic are a with a rare form of lattice corneal dystrophy (LCD). METHODS:Detailed ophthalmologic analysis was carried out on a Bulgarian woman, enrolled for perforating keratoplasty. In order to obtain a final diagnosis both histology and g...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210501500624
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:The present study compared the expression of brain-derived neurotrophic factor (BDNF) in the lateral geniculate body between form deprivation amblyopia kittens and normal kittens to examine the significance of BDNF in the lateral geniculate body in the pathogenesis of amblyopia. METHODS:Twenty kittens were div...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120953341
更新日期:2020-09-01 00:00:00
abstract:AIM:To review published literature concerning cataract surgery and dry eye disease (DED). METHODS:A search was undertaken using the following: PubMed (all years), Web of Science (all years), Ovid MEDLINE(R) (1946 to 12 December 2019), Ovid MEDLINE(R) Daily Update 10 December 2019, MEDLINE and MEDLINE non-indexed items...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
abstract::Although it is now possible to significantly reduce the incidence of blindness secondary to diabetes mellitus, large numbers of diabetic patients still experience visual loss due to retinal complications of the disease. This implies that protocols for the diagnosis and treatment of diabetic retinopathy used in the var...
journal_title:European journal of ophthalmology
pub_type: 社论
doi:10.1177/112067219900900302
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:To look for ophthalmologic abnormalities in 15 patients with Wolfram syndrome, also known as DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). METHODS:Fifteen patients from four inbred families diagnosed as having Wolfram syndrome at the National Center for Diabetes, Endocri...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200202
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:To assess signs of dry eye syndrome in keratoconic eyes following intracorneal ring segment (ICRS) implantation. PATIENT AND METHODS:Twenty eyes of 20 consecutive patients with keratoconus were assessed for tear film changes following ICRS implantation at 6 months postoperatively. Evaluated parameters included...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120958301
更新日期:2020-09-21 00:00:00