Abstract：
PURPOSE:To look for ophthalmologic abnormalities in 15 patients with Wolfram syndrome, also known as DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). METHODS:Fifteen patients from four inbred families diagnosed as having Wolfram syndrome at the National Center for Diabetes, Endocrinology and Genetics, in Amman, Jordan, were evaluated ophthalmologically. Their examination included best-corrected visual acuity, color vision testing, pupillary light reflexes, slit-lamp biomicroscopy and fundus examination. Fundus fluorescein angiography was done in all patients. RESULTS:The prevalence of optic atrophy was (93.3%), colordefect (92.9%), cataract (66.6%), pigmentary retinopathy (30%) and diabetic retinopathy (20%). Abnormal pupillary light reflexes and nystagmus were also reported. CONCLUSIONS:Although ourgroup of patients was genetically heterogeneous, the ophthalmic findings are consistent with those reported in other series, except for cataract which was highly prevalent but mild and did not contribute significantly to loss of vision.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Al-Till M,Jarrah NS,Ajlouni KMdoi
10.1177/112067210201200202subject
Has Abstractpub_date
2002-03-01 00:00:00pages
84-8issue
2eissn
1120-6721issn
1724-6016journal_volume
12pub_type
杂志文章abstract：PURPOSE:To illustrate the successful outcome of pars plana vitrectomy (PPV) with melphalan irrigation for vitreous hemorrhage (VH) with suspected viable retinoblastoma. Despite the high risk of intraocular surgery, it was performed to preserve the only potentially seeing eye with treated retinoblastoma. METHODS:Vitreo...
journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
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abstract：PURPOSE:To describe a case of bilateral eyelid-confined giant cell angiofibroma (GCAF) in a patient with a slowly progressive bilateral eyelid swelling. METHODS:A 40-year-old man with a 5-year history of slowly progressive bilateral eyelid swelling, severe functional impairment, and bilateral cosmetic deformity was st...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000608
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Garcinia cambogia contains hydroxycitric acid. Hydroxycitric acid is a potent competitive inhibitor of adenosine triphosphate citrate lyase which is a key enzyme in the synthesis of fatty acids. Hydroxycitric acid also regulates the level of serotonin. In these regards, hydroxycitric acid has been reported t...
journal_title：European journal of ophthalmology
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abstract：INTRODUCTION:The aim of this study was to evaluate repeatability and reproducibility of newly calculated biomechanical parameters of the cornea, developed by our research group. METHODS:One eye from each of the 23 healthy subjects was measured three times consecutively, three times at different daytimes and on three d...
journal_title：European journal of ophthalmology
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abstract：PURPOSE:To survey the routine practice of consultant ophthalmic surgeons in the United Kingdom in preventing postoperative endophthalmitis following cataract surgery. METHODS:This is a cross-sectional questionnaire-based study. A questionnaire was sent to consultant ophthalmic surgeons in university teaching hospital ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1177/112067210601600306
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abstract：PURPOSE:To compare the efficacy of selective laser trabeculoplasty (SLT) to argon laser trabeculoplasty (ALT) as treatment and retreatment to lower intraocular pressure (IOP) in patients with uncontrolled open-angle glaucoma (OAG) on maximally tolerated medication therapy with a follow-up of 12 months. METHODS:A total...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2009-05-01 00:00:00
abstract：:Idiopathic macular holes have long been considered to be a stable, untreatable condition with little or no chance of spontaneous visual improvement. Within the last few years, surgical intervention has been developed for the management of idiopathic Stage 3 and Stage 4 holes. With pars plana vitrectomy surgery, at lea...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
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abstract：PURPOSE:Choroidal neovascularization (CNV) is a rare complication after laser photocoagulation for disorders such as central serous chorioretinopathy (CSC). METHODS:We report 2 patients who developed CNV after laser treatment for persistent CSC and were treated by 3 1.25-mg intravitreal injections of bevacizumab in 1-...
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000111
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abstract：PURPOSE:To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy. METHODS:In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy ...
journal_title：European journal of ophthalmology
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doi：10.5301/ejo.5000887
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
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doi：
更新日期：1992-07-01 00:00:00
abstract：PURPOSE:To investigate visual function and ocular features in children with attention deficit hyperactivity disorder (ADHD). METHODS:Fifty-one children underwent a detailed ophthalmologic evaluation. Thirty-two were diagnosed with ADHD, and 19 children with attention deficit disorder (ADD). The mean age was 9.9±3.1 ye...
journal_title：European journal of ophthalmology
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abstract：:Retinal ganglion cells (RGCs) undergo programmed cell death (apoptosis) after axonal injury. This cell death is mediated by several mechanisms, including deprivation of neurotrophic factors, alterations in gene expression, and production of reactive oxygen species. However, death of RGCs is delayed after axonal injury...
journal_title：European journal of ophthalmology
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doi：
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journal_title：European journal of ophthalmology
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abstract：PURPOSE:The present study compared the expression of brain-derived neurotrophic factor (BDNF) in the lateral geniculate body between form deprivation amblyopia kittens and normal kittens to examine the significance of BDNF in the lateral geniculate body in the pathogenesis of amblyopia. METHODS:Twenty kittens were div...
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更新日期：2020-09-01 00:00:00
abstract：PURPOSE:The aim of this study is to compare the outcomes of micropulse transscleral cyclophotocoagulation between primary open-angle glaucoma, pseudoexfoliation glaucoma, and other types of secondary glaucoma. METHODS:Outcomes of 96 consecutive patients with refractory, end-stage glaucoma treated with micropulse trans...
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
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更新日期：2012-06-15 00:00:00
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更新日期：2017-06-26 00:00:00
