Abstract：
PURPOSE:To evaluate the effect of intracameral Bevacizumab on trabeculectomy success rates. METHODS:A prospective, randomized, interventional clinical trial. Patients with primary open-angle glaucoma were randomly assigned to two groups: trabeculectomy with mitomycin C and trabeculectomy with mitomycin C and intracameral bevacizumab. Complete success is defined as an intraocular pressure (IOP) reduction of at least 30% from baseline IOP to a measured pressure of between 5 and 18 mm Hg without the use of IOP lowering medications. Qualified success is defined as same achievement of reduced IOP, but with the use of IOP lowering medications. Overall success is defined as same achievement of reduced IOP with or without the use of IOP lowering medications. RESULTS:Thirty-three patients in the mitomycin C group and 36 patients in the mitomycin C and bevacizumab group were included in final analyses. The IOP at presentation was 28.3 ± 8 and 28.4 ± 8.6 mm Hg, compared to 10.8 ± 3.4 and 12.3 ± 3.7 mm Hg at 12 months (p < 0.0001) for the mitomycin C group and the mitomycin C and bevacizumab group, respectively. Complete success at 12 months was achieved in 65% of the mitomycin C group compared to 60% of the mitomycin C and bevacizumab group (p = 0.77). Overall success was achieved in 82% compared to 80% of patients at 12 months (p = 0.78). Both groups showed a statistically significant reduction in IOP after 6 and 12 months (p ⩽ 0.001). There were no statistically significant differences in visual acuity and complications. CONCLUSION:Intracameral bevacizumab during mitomycin C trabeculectomy in patients with primary open-angle glaucoma apparently does not improve success rates. The adjuvant use of intracameral bevacizumab is therefore not justified.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Rabina G,Barequet D,Mimouni M,Kurtz S,Shemesh G,Rosenblatt A,Rosenfeld Edoi
10.1177/1120672119874682subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1356-1361issue
6eissn
1120-6721issn
1724-6016journal_volume
30pub_type
杂志文章,随机对照试验abstract：PURPOSE:To evaluate the use of the resorbable polylactic acid polymer implants (Resorb X) in the management of orbital floor blow-out fractures as regards safety, cosmetic, and functional results. METHODS:In a prospective, interventional case series, 22 patients with traumatic blow-out floor fractures underwent lower ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120928005
更新日期：2020-05-31 00:00:00
abstract：PURPOSE:Parry-Romberg syndrome (PRS) is a rare disease of unknown etiology and pathogenesis, characterized by progressive hemifacial atrophy. Diverse ocular manifestations were reported in association with PRS, including enophthalmos, lid retraction, blepharoptosis, restrictive strabismus, ocular motor nerve dysfunctio...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000132
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Transforming growth factor-beta1 (TGF-beta1) is thought to play a pivotal role in the regulation of the wound healing process after glaucoma filtering surgery. The aim of the present study was to investigate whether platelet-derived growth factor isoforms (PDGF-AA, PDGF-BB), basic fibroblast growth factor (bFGF...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210001000203
更新日期：2000-04-01 00:00:00
abstract：PURPOSE:To report a case of bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. METHODS:A 61-year-old man with POEMS syndrome had bilateral anterior optic neuropathy and unilat...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210901900129
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To compare diagnostic capabilities and agreement between Oculus-Spark perimetry and 3 procedures of glaucoma morphologic analysis. METHODS:A total of 102 normal eyes and 104 consecutive eyes with suspected or confirmed glaucoma (1 eye per subject) were analyzed in a prospective observational case-control study...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000233
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:To quantify the maximal level of temperature and the time the maximal temperature is achieved and correlate the temperature parameters to the mean rate of endothelial cell loss after standardized ultrasound delivery assisted with four viscoelastic substances or different temperature of balanced salt solution (B...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:The aim of this study was to report the 12-year longitudinal trends in indication and corneal transplantation techniques in France from 2004 to 2015. RESULTS:The records of all corneal transplantations performed from 2004 to 2015 in France were retrospectively reviewed. The patient indications and types of tra...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672118762224
更新日期：2018-09-01 00:00:00
abstract：SIGNIFICANCE:Susac's syndrome is a rare retinocochleocerebral immune-mediated endotheliopathy and clinically manifests as a pathognomonic triad of encephalopathy, hearing loss, and branch retinal artery occlusion. This triad is rarely present at symptom onset, thus, it is often initially misdiagnosed. To date, Susac's ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120924545
更新日期：2020-05-07 00:00:00
abstract：PURPOSE:To study the impact of ocular hypotensive lipids (OHL) on the incidence, progression, and response to treatment of clinically significant diabetic macular edema (CSDME). METHODS:A total of 379 patients (232 female, 147 male) with a history of diabetes mellitus (DM) and primary open-angle glaucoma (POAG) were i...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000109
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To evaluate diabetic retinopathy (DR) prevalence and risk factors, and the effectiveness of nonmydriatic fundus camera as a screening tool for the detection of DR, in a safety net hospital. METHODS:This was a retrospective, population-based, cross-sectional study. Diabetic patients, referred by their primary c...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000515
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:To present outcome data on low risk primary trabeculectomy augmented with low dose peroperative (0.1 mg/mL for 1 minute) mitomycin-C (MMC). METHODS:Retrospective case note review. All cases of trabeculectomy utilizing MMC augmentation at a concentration of 0.1 mg/mL with an application time of 1 minute and at ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:The objectives of this study were two-fold: to identify tear histamine content and its relationship to changes in tear histaminase activity during the early (EPR) and late phases (LPR) of the allergic reaction induced by a conjunctival provocation test (CPT) and to evaluate the effects of lodoxamide on histamine relea...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:Several types of inborn errors of the O-glycan biosynthesis are known, leading to clinically very distinct phenotypes. Children with O-mannosyl glycan biosynthesis defects commonly present as a severe form of congenital muscular dystrophy with decreased alpha-dystroglycan staining, congenital eye anomalies, and...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600134
更新日期：2006-01-01 00:00:00
abstract：PURPOSE:To describe a case of multiorganism, drug-resistant keratitis that responded well to corneal crosslinking (CXL) treatment. METHODS:A 52-year-old man presented to our institute with a 2-month ocular history of infectious keratitis in his right eye, on topical antibacterial, antifungal, and antiprotozoan treatme...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000755
更新日期：2016-07-01 00:00:00
abstract：:Indocyanine green video-angiography (ICG) was done twice on three patients with choroidal osteoma. Choroidal osteoma consisted of two portions, a yellow-white area and a surrounding orange area. The early phase of ICG angiography showed hypofluorescence due to blockage, corresponding to the osteoma. However, the hypof...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：PURPOSE:To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS:This hospital-based case ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000852
更新日期：2017-01-19 00:00:00
abstract：PURPOSE:The authors report the ophthalmic characteristics of a male proband in a Japanese family with autosomal dominant optic atrophy (DOA) harboring a frameshift mutation in the OPA1 gene. METHODS:Conventional ophthalmologic examinations including static automated perimetry were performed, as well as assessment of t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700216
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:To investigate whether topical nonsteroidal antiinflammatory drugs (NSAIDs) are useful, in the absence of concomitant corticosteroid therapy, in limiting postoperative inflammation after uncomplicated cataract surgery. METHODS:A total of 328 patients were enrolled in a prospective, randomized, double-masked, p...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2005-09-01 00:00:00
abstract：:S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol/l sodium hydroxide) of the rabbit. The drug was topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：PURPOSE:To evaluate optical coherence tomography (OCT) modifications of outer retinal layers as determinants for functional recovery after surgery for idiopathic macular hole (IMH). METHODS:This prospective study included 23 eyes of 23 consecutive patients who underwent vitreoretinal surgery for IMH. We excluded patie...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000905
更新日期：2017-03-10 00:00:00
abstract：PURPOSE:To look for ophthalmologic abnormalities in 15 patients with Wolfram syndrome, also known as DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). METHODS:Fifteen patients from four inbred families diagnosed as having Wolfram syndrome at the National Center for Diabetes, Endocri...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210201200202
更新日期：2002-03-01 00:00:00
abstract：PURPOSE:To determine agreement between peripapillary retinal nerve fiber layer (RNFL) thickness measurements by 2 spectral domain optical coherence tomography (SD-OCT) instruments. METHODS:. This was an observational, cross-sectional study. Both eyes of 89 subjects, 44 healthy subjects (mean age, 47±15 years) and 45 ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000167
更新日期：2013-05-01 00:00:00
abstract：PURPOSE:Preoperative and postoperative optical coherence tomography (OCT) of macular pathologies can be regarded as the gold standard diagnostic technique, providing detailed information on the microstructures of the macula for planning the surgical procedure and comparing improvements after surgery in the follow-up pe...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5001058
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To report clinical and confocal microscopy features of late-onset Candida albicans keratitis after Descemet stripping automated keratoplasty (DSAEK). METHODS:We performed clinical and confocal scan on a patient who underwent DSAEK and phacoemulsification for Fuchs endothelial dystrophy and cataract. RESULTS:A...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.6228
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:To estimate the incidence of retinopathy of prematurity and other ocular problems in a population of preterm infants. METHODS:This retrospective study included all infants with gestational age (GA) <32 weeks and birth weight (BW) <1500 g cared for in the neonatal intensive care unit (NICU) over a period of nin...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210201200610
更新日期：2002-11-01 00:00:00
abstract：PURPOSE:To describe the safety and efficacy of intravitreal tissue plasminogen activator (tPA) and sulfur hexafluoride (SF6) gas with sequential photodynamic therapy (PDT) in the management of submacular hemorrhage (SMH) associated with macular degeneration (MD). METHODS:Consecutive case series of five patients presen...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210801800415
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:Timely screening of premature babies is an important initial step in the management of retinopathy of prematurity (ROP) as earlier treatment results in improved visual prognosis. Screening criteria for ROP currently recommended by the American Academy of Pediatrics may not be applicable in developing countries....
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000417
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:Various methods have been used for testing peripheral visual field disturbances such as defects caused by drug toxicity. Static threshold perimetry with Humphrey Field Analyzer (HFA) is widely available. The aim of this study was to better define the normal thresholds for peripheral visual field (PVF) sensitivi...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.6299
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:To compare the inhibitory effects of a topical combination product, cromolyn sodium (DSCG) 4% with the antihistamine, chlorpheniramine, with those of topical ketotifen 0.05% on the clinical allergic reaction induced by the conjunctival allergen challenge (CAC). METHODS:Ten allergic but non-active patients were...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/112067210301300202
更新日期：2003-03-01 00:00:00
abstract：PURPOSE:To report three cases of bilateral primary choroidal melanoma treated with bilateral plaque radiotherapy. METHODS:Retrospective, single-center case series. RESULTS:Case 1: In 1981, a 50-year-old man was diagnosed with a 5-mm-thick choroidal melanoma in the right eye (OD) and treated with plaque radiotherapy. ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600619
更新日期：2006-11-01 00:00:00
