Abuse of vasoconstrictive eyedrops mimicking an ocular pemphigoid.

Abstract:

PURPOSE:To describe conjunctival histopathologic alterations induced by excessive chronic astringent use. METHODS:Report of a case with clinical picture, epicutane test results, histologic workup of conjunctival biopsy using conventional staining, and immunohistochemical markers. RESULTS:A 45-year-old man using a phenylephrine preparation hourly for years presented with grotesque eye redness, fornix shortening, and scarring of puncta lacrimalia. Direct and indirect immunofluorescence were negative for ocular pemphigoid. Histology revealed signs of chronic inflammation and neovascularization in the conjunctiva. Symptoms resolved after cessation of therapy. CONCLUSIONS:Chronic abuse of decongestant eyedrops can produce a clinical picture resembling an ocular pemphigoid. Histology suggests that late onset immunoreaction and chronic vasoconstriction cause chronic inflammation and neovascularization, respectively.

journal_name

Eur J Ophthalmol

authors

Tappeiner C,Sarra GM,Abegg M

doi

10.1177/112067210901900119

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

129-32

issue

1

eissn

1120-6721

issn

1724-6016

journal_volume

19

pub_type

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