Abstract：
PURPOSE:To evaluate the safety and efficacy of oral steroids when combined with long-term oral azathioprine (AZA) and orbital radiotherapy in patients with active thyroid-related restrictive myopathy. METHODS:A total of 88 patients from adnexal outpatient clinics of Bristol Eye Hospital, UK, and 2nd Department of Ophthalmology at Aristotle University of Thessaloniki, Greece, were enrolled in a retrospective, twin-center study. All patients were diagnosed with active thyroid eye disease and concomitant restrictive myopathy. Treatment included oral AZA, low-dose steroids, and orbital radiotherapy (20 Gy). Clinical activity scores as well as orthoptic assessments were consistently evaluated. Clinical activity scores, improved levels of diplopia, and single muscle excursions were considered major criteria for treatment success. RESULTS:Clinical success was achieved in 54 (61.4%), 57 (64.8%), and 61 (69.3%) patients at 3-, 6-, and 12-month time points, respectively, after the initiation of the combined treatment. At 18 months following initiation of treatment, the percentage of treatment success reached 73.9% (n = 65). Nine patients developed AZA-related side effects. In 4 patients the drug had to be discontinued. CONCLUSIONS:Combined immunosuppression with orbital radiotherapy appears to reduce morbidity in patients with marked restrictive myopathy by improving major motility parameters such as diplopia and duction amplitude.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Chalvatzis NT,Tzamalis AK,Kalantzis GK,El-Hindy N,Dimitrakos SA,Potts MJdoi
10.5301/ejo.5000463subject
Has Abstractpub_date
2014-11-01 00:00:00pages
953-9issue
6eissn
1120-6721issn
1724-6016pii
689A1D44-B34C-4CD7-8158-2950760F36ACjournal_volume
24pub_type
杂志文章,多中心研究abstract：PURPOSE:To evaluate the role of postoperative prone posturing for a single night in the outcome of trans pars plana vitrectomy (TPPV) with internal limiting membrane (ILM) peel and 20% perfluoroethane (C2F6) internal tamponade for idiopathic macular hole. METHODS:This prospective trial enrolled 14 eyes in 14 consecuti...
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