Abstract:
PURPOSE:To report a case of recurrent cytomegalovirus (CMV) corneal endotheliitis after penetrating keratoplasty. METHODS:Penetrating keratoplasty (PK) was performed in a 49-year-old man with bullous keratopathy. Pigmented keratic precipitates (KPs) were found in the corneal endothelium of the graft 13 days after surgery, with the subsequent appearance of coin-shaped lesions. Confocal microscopy was performed on the corneal endothelium. Aqueous humor was analyzed for viral DNA by polymerase chain reaction (PCR). RESULTS:CMV DNA was detected from the excised corneal button, and aqueous humor revealed positive results for CMV and HSV1 by PCR. Confocal microscopy showed large corneal endothelial cells, consistent with the typical owl's eye morphology of CMV endotheliitis. After systemic ganciclovir was administered, the pigmented KPs and coin-shaped lesions gradually decreased. CONCLUSIONS:Stress from surgery and corticosteroid usage can revitalize CMV activity. PCR and confocal microscopy are valuable for the diagnosis of CMV corneal endotheliitis.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Wang SC,Tsai IL,Lin HC,Kuo LL,Tsai CY,Liou SWdoi
10.1177/112067211002000231subject
Has Abstractpub_date
2010-03-01 00:00:00pages
457-9issue
2eissn
1120-6721issn
1724-6016pii
EB327A48-BA79-4948-9A21-5E56E433B1E9journal_volume
20pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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