Abstract:
OBJECTIVE:To identify complications associated with tumor-related lipid exudation (TRLE) after plaque radiotherapy of posterior uveal melanoma. METHODS:Comparative study including 294 patients with posterior uveal melanoma who developed TRLE after plaque radiotherapy (TRLE group) and 294 patients who did not develop TRLE (non-TRLE group). Patients in the TRLE group were matched with patients in the non-TRLE group for age, gender, and initial tumor thickness. RESULTS:The TRLE group was associated with significantly higher incidence of postradiation complications including early transient increase of serous retinal detachment (p<0.001), iris neovascularization (NVI) (p<0.001), neovascular glaucoma (NVG) (p<0.001), posterior synechia (p<0.001), vitreous hemorrhage (p<0.001), subretinal hemorrhage (p<0.001), and retinoschisis (p<0.001). A significant relationship was found between extent of TRLE and NVI (p<0.001), NVG (p<0.001), posterior synechia (p = 0.007), and retinoschisis over tumor (p = 0.010). Radiation-induced retinopathy, maculopathy, and papillopathy were not associated with presence or extent of TRLE. Tumor-related lipid exudation was also associated with worse final visual acuity (p = 0.011), higher rate of secondary enucleation (p<0.001), and lower rate of systemic metastasis (p = 0.006). CONCLUSIONS:Tumor-related lipid exudation following plaque radiotherapy of posterior uveal melanoma is associated with major intraocular complications and portends poor prognosis for final visual acuity and eye retention. These findings provide evidence for the presence of 2 distinct pathogenic mechanisms, one radiation-induced and one tumor-related, in development of postradiation complications in eyes with posterior uveal melanoma.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Mashayekhi A,Tuncer S,Shields CL,Shields JAdoi
10.5301/ejo.5000236subject
Has Abstractpub_date
2013-05-01 00:00:00pages
399-409issue
3eissn
1120-6721issn
1724-6016pii
48154C98-0737-433D-865D-9B056467CE6Ejournal_volume
23pub_type
杂志文章abstract:PURPOSE:To discuss how optical coherence tomography can be used to identify separated lenticular planes during small incision lenticule extraction (SMILE). METHODS:SMILE procedures were performed on 26 eyes of 13 patients. An anterior segment optical coherence tomography examination was performed after laser scan. Ant...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119853207
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To estimate the prevalence of lens opacities in a group of elderly people and evaluate their relation with diverse risk factors. METHODS:Cross-sectional observational study of the cohort of all persons over the age of 64 years from an urban area and a rural nucleus of the province of Cuenca, Spain. Information...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700105
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Good binocular potential has been a fundamental defining characteristic of acute acquired concomitant esotropia (AACE) type II. The purpose of this study was to ascertain the clinical features and surgical outcome in children with AACE type II who underwent repeated surgery for the sake of binocularity. METHOD...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000301
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:To evaluate the effect of oral prednisolone on visual outcomes and complications of scleral buckling (SB) in phakic eyes with acute rhegmatogenous retinal detachment (RRD). METHODS:In a randomized double-blind placebo-controlled trial, patients with acute RRD underwent SB. The treatment group received 1 mg/kg ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067211002000224
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:In this article, we evaluate subfoveal choroidal thickness in celiac patients with respect to adherence to the gluten-free diet and nonadherence to the gluten-free diet, comparing with age and sex matched healthy controls using spectral-domain optical coherence tomography. MATERIALS AND METHODS:A case-control ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119850071
更新日期:2020-09-01 00:00:00
abstract::The objectives of this study were two-fold: to identify tear histamine content and its relationship to changes in tear histaminase activity during the early (EPR) and late phases (LPR) of the allergic reaction induced by a conjunctival provocation test (CPT) and to evaluate the effects of lodoxamide on histamine relea...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:To review methods of assessing bulbar redness, particularly with respect to the practicality of comparing different rating systems. METHODS:The published literature was reviewed and discussed by a panel of experts and a narrative review prepared. RESULTS:Bulbar hyperemia is a common clinical sign and an impor...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.5301/ejo.5000626
更新日期:2015-07-01 00:00:00
abstract:PURPOSE:The aim of this article is to describe a novel surgical technique for sutureless scleral fixation of an intraocular lens using the newly developed FIL SSF Carlevale IOL (Soleko, Italy). METHODS:Four eyes of four patients with poor capsular support were recruited to our study, three resulting from intraocular l...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120902020
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:This prospective, randomized, double-masked, clinical trial was designed to evaluate visual acuity, contrast sensitivity, subjective quality of vision, and quality of life in 47 patients symmetrically, and randomly, implanted with 4 different IOL designs (SN6AD1, SN60D3, ReZoom NXG1, and Tecnis ZMA00), 3 months...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.5301/EJO.2011.8371
更新日期:2012-03-01 00:00:00
abstract::Purpose. Extraocular muscle (EOM) pulleys are important in eye movement physiology and may play a role in the outcome of strabismus surgery. Few studies have evaluated "normal" position of EOM pulleys. We sought to assess intraoperatively medial rectus (MR) pulley location and variations in a prospective observational...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000187
更新日期:2013-01-21 00:00:00
abstract:PURPOSE:Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopathy. The aim of our study was to analyze effect of 1.25 mg of intravitreal Avastin on serum concentration of vascular endothelial growth factor (VEGF) in diabetic patients. METHODS:Participants were 10 diabetic pati...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000118
更新日期:2012-09-01 00:00:00
abstract::We present an unusual case of Sturge-Weber syndrome whose main clinical manifestations were nevus flammeus, seizures, glaucoma, and acoria. To our knowledge, the combination of Sturge-Weber syndrome and acoria has not been previously reported. ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118804795
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate persistency (time on initial therapy) and the clinical impact of latanoprost versus beta-blocker monotherapy in treating glaucoma. METHODS:This observational, multicenter, retrospective medical chart review study conducted in four European countries included patients with primary open-angle glaucom...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1177/112067210301304s03
更新日期:2003-07-01 00:00:00
abstract::Ultrasound tissue characterization parameters of size and acoustic concentration can be used to sub-classify uveal melanoma and estimate the patient's risk of death. Histologically determined microcirculation patterns have also been found to sub-classify uveal melanoma and predict patient's risk of death. This study e...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::A 62-year-old female developed pseudophakic bullous keratopathy after cataract surgery and underwent Descemet stripping automated endothelial keratoplasty (DSAEK). Intraoperatively, a white opacified pre-Descemet's layer was noticed after scoring and removal of trypan blue stained Descemet's membrane (DM), and endothe...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120974271
更新日期:2020-11-30 00:00:00
abstract:PURPOSE:This study aimed to investigate the role of protein peroxidation by detecting the serum levels of advanced oxidation protein products (AOPP), a novel marker for the degree of oxidative damage to proteins, and total thiol as a marker of antioxidant status in diabetic patients with or without diabetic retinopathy...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800521
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:The authors report the ophthalmic characteristics of a male proband in a Japanese family with autosomal dominant optic atrophy (DOA) harboring a frameshift mutation in the OPA1 gene. METHODS:Conventional ophthalmologic examinations including static automated perimetry were performed, as well as assessment of t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700216
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:To review the current practice of retreatment with Ozurdex injections in patients with macular edema (ME) secondary to retinal vein occlusion (RVO), and to recommend simple guidelines for Ozurdex reinjection in management of RVO. METHODS:This was a multicenter retrospective study of patients who received more ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.5301/ejo.5000376
更新日期:2014-01-01 00:00:00
abstract:AIM:To test if hyaluronic acid gel injection in the upper eyelid achieves correction of congenital cicatricial ectropion and reduction in lagophthalmos, in preparation for intraocular surgery. METHODS:This case reports the long-term outcome of hyaluronic acid gel injection in the upper eyelid for the correction of ect...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118805622
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To compare 4 limbal-conjunctival autograft fixation techniques-conventional suture, commercial fibrin glue, autologous fibrin glue, and cautery-in primary nasal pterygium surgery. METHODS:This is a retrospective and descriptive study. The postoperative patient discomfort, graft edema, ocular inflammation, and ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000924
更新日期:2017-06-26 00:00:00
abstract::Considerable improvement has been achieved in the way in which exudative age-related macular degeneration is conventionally treated and in the associated visual outcomes and prognosis, thanks to the agents with effects against vascular endothelial growth factor (anti-VEGF). By comparison to earlier treatment approache...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672119832432
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To compare the efficacy of selective laser trabeculoplasty (SLT) to argon laser trabeculoplasty (ALT) as treatment and retreatment to lower intraocular pressure (IOP) in patients with uncontrolled open-angle glaucoma (OAG) on maximally tolerated medication therapy with a follow-up of 12 months. METHODS:A total...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067210901900317
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Scleral buckling (SB) has been the first technique to repair a retinal detachment (RD) and it is still largely in use. Pars plana vitrectomy (PPV) is currently the most common technique, being more versatile and easier to approach. Here we report on a new SB variant, modified by using some of the latest te...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120945091
更新日期:2020-07-22 00:00:00
abstract:PURPOSE:To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy. METHODS:In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000887
更新日期:2017-05-11 00:00:00
abstract:PURPOSE:To evaluate the effect of astigmatism axis on uncorrected distance visual acuity (UDVA) in emmetropic eyes that underwent laser refractive surgery. METHODS:This retrospective study included patients who underwent laser in situ keratomileusis or photorefractive keratectomy between January 2000 and December 2015...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000890
更新日期:2017-05-11 00:00:00
abstract:PURPOSE:To describe a case of bilateral eyelid-confined giant cell angiofibroma (GCAF) in a patient with a slowly progressive bilateral eyelid swelling. METHODS:A 40-year-old man with a 5-year history of slowly progressive bilateral eyelid swelling, severe functional impairment, and bilateral cosmetic deformity was st...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000608
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:This study was conducted in 2002-2003 at selected schools of eight health regions of Oman. The authors present risk factors and predictors of progression of myopia between the 7th and 10th grades. METHODS:This was a historical cohort study. A total of 1304 students in 10th grade, both with and without progress...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700115
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:We report spectral domain optical coherence tomography findings of the peripheral retina in a patient with senile (acquired) retinoschisis. METHODS:This is an observational case report. Spectral domain optical coherence tomography was performed to image the peripheral retina at the area of retinoschisis in a 7...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000610
更新日期:2010-11-01 00:00:00
abstract::Astigmatic changes in three series of cataract surgical procedures were compared. The first two series comprised eyes having a manual extracapsular cataract extraction (ECCE) through a 12.0 mm or 8.0 mm incision and implant of a PMMA posterior chamber lens. The third series comprised eyes having phacoemulsification th...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:PURPOSE:To report a case of tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) with unusual unilateral neuroretinitis. METHODS:An 11-year-old girl who developed anterior uveitis 3 months after acute tubulointerstitial nephritis, without any etiologic factors for either nephritis or uveitis, is presented...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00