Abstract:
:Considerable improvement has been achieved in the way in which exudative age-related macular degeneration is conventionally treated and in the associated visual outcomes and prognosis, thanks to the agents with effects against vascular endothelial growth factor (anti-VEGF). By comparison to earlier treatment approaches that involved the use of lasers, the anti-VEGF agents have made it possible to accomplish more positive visual and anatomical outcomes in cases of exudative age-related macular degeneration. Indeed, owing to their positive effects, anti-VEGF agents have quickly come to be considered the gold standard for the treatment of wet age-related macular degeneration. Aflibercept, the most recently approved intravitreally administered anti-VEGF, seems to mark another milestone in the treatment of wet age-related macular degeneration. This anti-VEGF agent presents a series of singular pharmacodynamic and pharmacokinetic attributes that provide it a number of biological benefits in relation to the treatment of choroidal neovascularization compared to other agents. These attributes include high level of affinity for the VEGF-A factor, an intravitreal half-life of great length, as well as the ability to serve as an antagonist for other growth factors besides VEGF. The impact of Aflibercept on the manner in which exudative age-related macular degeneration is managed was demonstrated by thoroughly reviewing the related literature. The present review article highlights the pharmacology, pharmacokinetics, safety and effectiveness of this anti-VEGF agent as well as the landmark clinical studies that have been carried out to establish this drug as a gold standard in the therapy of neovascular age-related macular degeneration. In addition, studies regarding the outcomes and effectiveness of the various dosage regimens, either as monotherapy or in combination with other agents, are also reviewed.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Papadopoulos Zdoi
10.1177/1120672119832432subject
Has Abstractpub_date
2019-07-01 00:00:00pages
368-378issue
4eissn
1120-6721issn
1724-6016journal_volume
29pub_type
杂志文章,评审abstract:PURPOSE:The aim of this study is to assess the agreement between manual and automated gonioscopy for iridocorneal angle opening. METHODS:The research is a cross-sectional observational study. Manual and automated gonioscopy were performed to consecutive patients in a glaucoma clinic. Iridocorneal angle opening grading...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118806436
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To determine the safety and efficacy of photodynamic therapy with verteporfin (V-PDT) in the treatment of exudative idiopathic polypoidal choroidal vasculopathy (IPCV) lesions that were not suitable for laser photocoagulation. METHODS:This was a prospective, open label study in two centers involving 30 consecu...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1177/112067210601600506
更新日期:2006-09-01 00:00:00
abstract:PURPOSE:Transforming growth factor-beta1 (TGF-beta1) is thought to play a pivotal role in the regulation of the wound healing process after glaucoma filtering surgery. The aim of the present study was to investigate whether platelet-derived growth factor isoforms (PDGF-AA, PDGF-BB), basic fibroblast growth factor (bFGF...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210001000203
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To report optical coherence tomography (OCT) and retinal thickness analyzer (RTA) findings in a case of spontaneous resolution of vitreomacular traction syndrome. METHODS:Qualitative and quantitative analysis of the macular region was performed with OCT and RTA. RESULTS:In the left eye of a 34-year-old woman ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210401400113
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To conduct an observational, multicenter study to evaluate real-world clinical efficacy and safety of the 0.2 µg/day fluocinolone acetonide (FAc) implant in the treatment of patients with chronic diabetic macular edema (DME) in 3 large hospital ophthalmology departments in the United Kingdom. METHODS:Fluocinol...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.5301/ejo.5000929
更新日期:2017-05-11 00:00:00
abstract:PURPOSE:To survey the routine practice of consultant ophthalmic surgeons in the United Kingdom in preventing postoperative endophthalmitis following cataract surgery. METHODS:This is a cross-sectional questionnaire-based study. A questionnaire was sent to consultant ophthalmic surgeons in university teaching hospital ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1177/112067210601600306
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To compare the efficacy of selective laser trabeculoplasty (SLT) to argon laser trabeculoplasty (ALT) as treatment and retreatment to lower intraocular pressure (IOP) in patients with uncontrolled open-angle glaucoma (OAG) on maximally tolerated medication therapy with a follow-up of 12 months. METHODS:A total...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067210901900317
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of fixed-combination brimonidine tartrate 0.2%/timolol 0.5% ophthalmic solution dosed BID and demonstrate non-inferiority to concomitant use of brimonidine tartrate 0.2% BID and timolol 0.5% BID in glaucoma and ocular hypertension patients with intraocular pressure (IOP) unco...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.4076
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To report a real-life experience with the Argus II retinal prosthesis system in blind patients with end-stage retinitis pigmentosa (RP) or choroideremia (CHM), focusing on the pivotal role of optical coherence tomography (OCT) in both preoperative and postoperative management. METHODS:This hospital-based case ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000852
更新日期:2017-01-19 00:00:00
abstract:PURPOSE:To describe conjunctival histopathologic alterations induced by excessive chronic astringent use. METHODS:Report of a case with clinical picture, epicutane test results, histologic workup of conjunctival biopsy using conventional staining, and immunohistochemical markers. RESULTS:A 45-year-old man using a phe...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900119
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To describe a case of intraocular lens opacification resembling pseudophakic pseudoexfoliation affecting an AkreosFit intraocular lens (IOL). METHODS:Single case analysis. RESULTS:A patient had IOL opacification resembling pseudophakic pseudoexfoliation. CONCLUSIONS:An 83-year-old woman with normal tension g...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
abstract:PURPOSE:To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy. METHODS:In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000887
更新日期:2017-05-11 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To describe the impact that social media usage has on a group of retina specialists. MATERIALS AND METHODS:An anonymous online survey was sent to members of the Young Retina Forum who use the social media platform - Telegram. RESULTS:Of a total of 178 members, 100 responded (87 men and 13 wom...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119832186
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To verify the functional and anatomical results of retinal detachments related to choroidal coloboma. METHODS:Seven eyes with retinal detachment secondary to retinal breaks at the margin of or within a choroidal coloboma were analysed retrospectively. RESULTS:Scleral buckling was performed in five of the seve...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200408
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:To determine the microbial contamination of the irrigating fluids at the time of phacoemulsification after the use of topical povidone-iodine and antibiotics prophylaxis. METHODS:A total of 119 patients undergoing cataract surgery were enrolled in this prospective study. All patients received 5 mg/mL levofloxa...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.8434
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Twenty-two people with a history of grass pollen allergic conjunctivitis were enrolled outside the pollen season in this study to compare the efficacy of 0.05% mequitazine eyedrops with topical 2% disodium cromoglycate. METHODS:This randomized, double-blind study compared right and left eyes. Subjects received...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/112067210001000103
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To report a new family belonging to a previously non-investigated geographic are a with a rare form of lattice corneal dystrophy (LCD). METHODS:Detailed ophthalmologic analysis was carried out on a Bulgarian woman, enrolled for perforating keratoplasty. In order to obtain a final diagnosis both histology and g...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210501500624
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To study the short-term effects of intravitreal bevacizumab (Avastin) on retinal blood flow velocity and compare them to clinical outcomes assessed by optical coherence tomography (OCT) and tests of visual acuity. METHODS:The Retinal Function Imager (RFI) was used noninvasively and quantitatively to measure re...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000074
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To investigate color perception and contrast sensitivity with and without additional glare in pseudophakic patients with a conventional intraocular lens (IOL) in one eye and a blue light-filtering IOL in the fellow eye. METHODS:Twenty-three bilaterally pseudophakic patients with a conventional IOL (AcrySof SA6...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900210
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy. METHODS:A prospective, fellow-eye sham controlled clinical trial was conducted on 80 eyes of 40 high-risk characteristic proliferative ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067210801800215
更新日期:2008-03-01 00:00:00
abstract:UNLABELLED:PURPOSE. To report a case of scleral dislocation mimicking glaucoma progression. METHODS:Interventional case report. RESULTS:A 71-year-old man was referred for glaucoma surgery in his right eye because of perimetry defect progression and uncontrolled intraocular pressure despite maximal medical therapy. A ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000165
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:To report a case of posterior microphthalomos (PM) related to PRSS56 gene mutation with long term follow up with multimodal imaging findings. METHODS:Single retrospective case report. RESULTS:A 43-year old male patient presented in 2009 with bilateral reduced vision. Clinical examination and multimodal imagin...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120949756
更新日期:2020-08-17 00:00:00
abstract:PURPOSE:To report on the intraocular use of a steroid slow-release device in an attempt to avoid multiple intraocular triamcinolone injections in chronic sympathetic ophthalmia. METHODS:A 47-year-old patient with sympathetic ophthalmia had received 17 intravitreal triamcinolone injections to suppress the uveitis, to i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800531
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To look for ophthalmologic abnormalities in 15 patients with Wolfram syndrome, also known as DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy and deafness). METHODS:Fifteen patients from four inbred families diagnosed as having Wolfram syndrome at the National Center for Diabetes, Endocri...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200202
更新日期:2002-03-01 00:00:00
abstract:PURPOSE:Handheld laser pointer thermal injury affects primarily the retinal pigment epithelium (RPE). However, so far no study has reported on the possible effects of laser pointers in the deeper layers, beneath the RPE. Here, we describe the spectral-domain optical coherence tomography angiography findings in the chor...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000844
更新日期:2017-01-19 00:00:00
abstract:PURPOSE:To evaluate the visual quality, visual performance, and patient satisfaction after the implantation of the last generation supplementary intraocular lens (1stQ AddOn Trifocal) for achieving near vision spectacle-independence in pseudophakic patients who had primary monofocal capsular bag implantation. METHODS:...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120969042
更新日期:2020-11-06 00:00:00
abstract:PURPOSE:To report spectral-domain optical coherence tomography (OCT) and fundus autofluorescence (FAF) features observed in a case of typical retinocytoma. METHODS:Case report. RESULTS:A 17-year-old girl on routine ophthalmologic evaluation for headache had an elevated translucent lesion with peripheral pigmentation ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000634
更新日期:2015-10-21 00:00:00
abstract:PURPOSE:To report a case of optic nerve and dura mater involvement as the first sign of multiple myeloma. METHODS:Case report. RESULTS:A 43-year-old woman presented with a headache and decreased vision in both eyes. Ophthalmic examination revealed anterior uveitis and subretinal mass around the optic nerves with acco...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000489
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To report a case of Candida albicans keratitis after Descemet stripping with automated endothelial keratoplasty (DSAEK) due to fungal contamination of the donor cornea. METHODS:Case report. RESULTS:A 73-year-old woman underwent phacoemulsification with intraocular lens (IOL) implantation and DSAEK with 1 week...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000499
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:To evaluate the long-term efficacy and safety of standard-fluence photodynamic therapy (PDT) with verteporfin using the minimum PDT spot size in patients with diffuse retinal pigment epitheliopathy (DRPE). METHODS:This is a retrospective study of 67 DRPE cases treated with PDT using a standardized minimum spot...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000541
更新日期:2015-05-01 00:00:00