Abstract:
PURPOSE:To study the short-term effects of intravitreal bevacizumab (Avastin) on retinal blood flow velocity and compare them to clinical outcomes assessed by optical coherence tomography (OCT) and tests of visual acuity. METHODS:The Retinal Function Imager (RFI) was used noninvasively and quantitatively to measure retinal blood flow velocity. Eight patients receiving intravitreal injection of Avastin for choroidal neovascularization (CNV) were included in this study. All were imaged by the RFI preinjection and 1 and 7 days postinjection. Visual acuity (VA) and OCT were recorded preinjection and 1 month postinjection. Comparisons were performed using paired Student t test and correlation using Spearman rank test. RESULTS:A good correlation was found between the 1-month change in VA and OCT measurements and the short-term change induced in blood flow velocity. Arterial and venous velocity changes 1 day after the injection correlated with the VA change (p<0.05). The 1-day arterial velocity changes correlated with total macular volume (p=0.02) and venous velocity changes correlated to central macular thickness (p = 0.04). CONCLUSIONS:The RFI provides a noninvasive technique to assess early hemodynamic responses to intravitreal injection of Avastin. These early changes may prove important for better understanding of the mechanism underlying this treatment and serve as a quantitative marker for treatment optimization.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Barak A,Burgansky-Eliash Z,Barash H,Nelson DA,Grinvald A,Loewenstein Adoi
10.5301/ejo.5000074subject
Has Abstractpub_date
2012-05-01 00:00:00pages
423-30issue
3eissn
1120-6721issn
1724-6016pii
FD90786C-B252-471E-B989-6EF42F435A45journal_volume
22pub_type
杂志文章abstract::A 50-year-old white man complained of "inflammation" of his right eyelid since January 1989. In June 1990, he had undergone a gastrectomy for an adenocarcinoma of the stomach. In August 1990, his right eye showed a painless, firm infiltration of the upper and lower lid, ulceration and loss of eyelashes of the upper li...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To compare the symptoms, signs, and results of objective tests for dry eye syndrome (DES) in type 1 diabetes mellitus (T1DM) patients and controls. METHODS:A total of 104 children with T1DM and 104 age- and sex-matched controls were compared in terms of the symptoms, signs, and results of objective tests for D...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700601
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:To emphasize and create awareness of the possibility of inadvertently grafting an inverted corneal button and describe 4 cases that showed this phenomenon on human donor corneas during preservation and transportation from an eye bank. METHODS:Three out of 4 tissues showed inadvertent inversion during transport...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000711
更新日期:2016-02-15 00:00:00
abstract:AIM:A multicentre, randomized, placebo-controlled double-masked study was conducted to assess the efficacy and safety of Rimexolone 1% eye drops in reducing inflammation after cataract surgery and intra-ocular lens implantation. METHODS:Rimexolone 1% (124 patients) or placebo (58 patients) was given, four times a day ...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:To evaluate changes in symptoms and tear film characteristics in young computer users. METHODS:Fifty-one computer users and 26 controls were evaluated at the beginning and the end of the working day. Subjects with ocular or systemic disease, history of ocular surgery, use of contact lenses or glasses with anti...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000525
更新日期:2015-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000165
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:The aim of this study is to evaluate the incidence, natural course, and distribution pattern of superficial punctate keratopathy and describe the changes in signs and symptoms of dry eye after cataract surgery. SETTING:The setting of this study is University Hospital Rio Hortega and Instituto Universitario de ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119896427
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:During the current coronavirus (COVID-19) pandemic, some ophthalmologists across the United Kingdom (UK) have been redeployed to areas of need across the National Health Service (NHS). This survey was performed to assess aspects of this process including training & education, tasks expected, availability of ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120953339
更新日期:2020-08-27 00:00:00
abstract:PURPOSE:To report on the efficacy and safety of combined phacoemulsification and an Ahmed valve glaucoma drainage implant with respect to visual acuity improvement, intraocular pressure (IOP) control, and requirement for antiglaucoma medication. METHODS:A retrospective chart review was conducted of 41 eyes (31 patient...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800205
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:The aim of this study is to assess the agreement between manual and automated gonioscopy for iridocorneal angle opening. METHODS:The research is a cross-sectional observational study. Manual and automated gonioscopy were performed to consecutive patients in a glaucoma clinic. Iridocorneal angle opening grading...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118806436
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To report the results of corneal collagen crosslinking (CXL) in a patient with corneal ectasia developed after excimer laser-assisted lamellar keratoplasty for keratoconus and a secondary photorefractive keratectomy (PRK) for residual refractive error. METHODS:A 33-year-old woman, who had originally been treat...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000019
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:To prospectively compare the clinical results of two cataract surgery procedures through a 4.0-mm incision, differing only in the wound location (superior or lateral). METHODS:168 eyes with cataract were randomly assigned to either procedure. Except for incision location, surgical methods were identical. Uncor...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-10-01 00:00:00
abstract:PURPOSE:In this article, we evaluate subfoveal choroidal thickness in celiac patients with respect to adherence to the gluten-free diet and nonadherence to the gluten-free diet, comparing with age and sex matched healthy controls using spectral-domain optical coherence tomography. MATERIALS AND METHODS:A case-control ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119850071
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:The prognosis of visual acuity (VA) after branch retinal vein occlusion (BRVO) in patients with diabetes mellitus is unknown compared to the VA in non-diabetic patients with BRVO. The aim of this study was to evaluate the visual outcome of BRVO in diabetic and non-diabetic patients. METHODS:A retrospective cas...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1177/112067210301300709
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To evaluate perioperative changes in blood coagulation in patients undergoing retinal detachment surgery. MATERIALS:Prospective study of 56 patients, aged from 19 to 82 (mean +/- S.D. 53 +/- 16.8) years, undergoing retinal detachment surgery (encirclement with scleral buckling) under general anesthesia. Exclud...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210001000408
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:To describe the natural course of type 2 idiopathic macular telangiectasia (MT) using spectral-domain optical coherence tomography (SD-OCT). METHODS:Analysis of the different stages of progression of type 2 MT during a period of 3 years using multimodal imaging, including SD-OCT correlated with angiographic an...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000363
更新日期:2013-11-01 00:00:00
abstract:PURPOSE:To evaluate the clinical characteristics of the unusual late postoperative capsular block syndrome (CBS) and the effect of Nd:YAG laser posterior capsulotomy on visual acuity and refractive error as well as its possible complications. METHODS:In this retrospective cohort study, 12 eyes of 11 patients with late...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000507
更新日期:2015-01-01 00:00:00
abstract:AIMS:To investigate alterations in deep retinal vascular complex (DVC) in patients with non-neovascular intermediate AMD (iAMD), treatment-naïve quiescent macular neovascularization (qMNV), exudative AMD (eAMD) by means of OCT angiography (OCTA). METHODS:Patients with iAMD, qMNV, eAMD and healthy controls presenting i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120968758
更新日期:2020-11-03 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000421
更新日期:2010-07-01 00:00:00
abstract:PURPOSE:To survey the routine practice of consultant ophthalmic surgeons in the United Kingdom in preventing postoperative endophthalmitis following cataract surgery. METHODS:This is a cross-sectional questionnaire-based study. A questionnaire was sent to consultant ophthalmic surgeons in university teaching hospital ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1177/112067210601600306
更新日期:2006-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210401400103
更新日期:2004-01-01 00:00:00
abstract::Purpose. To record the information used in order to make a retreatment decision in patients with exudative age-related macular degeneration (AMD) and to assess if an optical coherence tomography (OCT)-only follow-up clinic would suffice. Methods. Two hundred patients under treatment with intravitreal anti-vascular end...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000190
更新日期:2012-08-06 00:00:00
abstract:PURPOSE:To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life. METHODS:A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year peri...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119862878
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To describe the detailed surgical technique used for harvesting and transplantation of autologous nasal mucosa grafts for ocular surface reconstruction, to evaluate the clinical results and utility of autologous nasal mucosa grafts in ocular surface diseases. METHODS:Autologous nasal mucosa was harvested from ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.6336
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To assess signs of dry eye syndrome in keratoconic eyes following intracorneal ring segment (ICRS) implantation. PATIENT AND METHODS:Twenty eyes of 20 consecutive patients with keratoconus were assessed for tear film changes following ICRS implantation at 6 months postoperatively. Evaluated parameters included...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120958301
更新日期:2020-09-21 00:00:00
abstract:PURPOSE:Reconstruction of the ocular surface is challenging. As an alternative to mucosal and limbal epithelial, we study the feasibility of cultivated human conjunctival epithelial (HCjE) cells of patients with total limbal stem cell deficiency (LSCD). METHODS:We studied superior forniceal conjunctival biopsies harve...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000511
更新日期:2014-11-06 00:00:00
abstract:PURPOSE:To examine the nature and frequency of ocular side effects due to systemic target therapy with BRAF and MEK inhibitors as well as immunotherapy with cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) monoclonal antibodies used in the treatment of cutaneous malignant melanoma (CMM). DE...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-05-31 00:00:00
abstract:PURPOSE:To assess corneal tissue modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus as well as regeneration of epithelium and subepithelial nerve plexus by in vivo HRT II system confocal microscopy in humans. METHODS:Ten patients with progressive kerat...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600405
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To compare topographic indices of surface regularity in dry eye patients and in normal subjects (controls) and to investigate the short-term effect of lacrimal punctal plugs on these indices in dry eye patients. METHODS:The surface regularity index (SRI) and surface asymmetry index (SAI) of the TMS-2 corneal t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210101100202
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:To describe the use of silicone oil (SO) in combination with subretinal recombinant tissue plasminogen activator (rtPA) to achieve dislocation of large subretinal hemorrhage secondary to exudative age-related macular degeneration (AMD). METHODS:A single-eye 81-year-old woman, known for exudative AMD, presented...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120952349
更新日期:2020-08-18 00:00:00