Abstract：
PURPOSE:To examine the nature and frequency of ocular side effects due to systemic target therapy with BRAF and MEK inhibitors as well as immunotherapy with cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) monoclonal antibodies used in the treatment of cutaneous malignant melanoma (CMM). DESIGN:While proven effective in cancer treatment, target therapy and immunotherapy have been associated with ocular side effects likely due to their ability to alter the immune privilege of the eye. We conducted a retrospective chart review of patients undergoing target and immunotherapy for CMM and documented all associated eye findings. METHODS:We reviewed the records of 34 patients receiving target and immunotherapy for CMM who were examined in the academic ophthalmology clinic between 2012 and 2017. RESULTS:Ocular side effects were present in 41.1% of patients in this study with 14.7% presenting with uveitis. Patients undergoing therapy with either vemurafenib only or dabrafenib/trametinib combination therapies comprised 70.5% of the study cohort. Ocular side effects occurred in 45.5% and 46.1% of patients on vemurafenib and dabrafenib/trametinib combination therapy, respectively. About 47.5% of males presented with ocular side effects compared to 30.5% of females. Notably, 13/14 patients with ocular symptoms recovered. CONCLUSION:This study highlights the frequency of ocular side effects in patients treated with target therapy and immunotherapy for CMM and shows that symptom resolution can be effectively achieved with proper ophthalmic care. Further research is required to answer whether cessation of these therapies is mandatory during ophthalmic treatment.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Eikenberry J,Harris A,Torabi R,Lang M,Denney D,Verticchio Vercellin A,Siesky Bdoi
10.1177/1120672120930688subject
Has Abstractpub_date
2020-05-31 00:00:00pages
1120672120930688eissn
1120-6721issn
1724-6016pub_type
杂志文章abstract：PURPOSE:To describe a technique for suturing a luxated intraocular lens (IOL) in the vitreous cavity directly to the ciliary sulcus using intraocular slipknot without IOL extraction. DESIGN:Noncomparative interventional case series. MATERIALS AND METHODS:A three-port vitrectomy was performed in all cases. According t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300604
更新日期：2003-07-01 00:00:00
abstract：:The risk factors for intraoperative and early postoperative complications were evaluated in 351 consecutive cataract operations at the Oulu University Hospital in 1990. Bleeding into the anterior chamber during the operation was recorded in 8.6%, zonular rupture in 6.6%, posterior capsular rupture in 5.4% and vitreous...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the intra-session repeatability and inter-examiner reproducibility of the colour perimetry technique when assessing in vivo macular pigment optical density in age-related macular degeneration patients. METHODS:Age-related macular degeneration patients were classified i...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119870362
更新日期：2020-11-01 00:00:00
abstract：:Ultrasound tissue characterization parameters of size and acoustic concentration can be used to sub-classify uveal melanoma and estimate the patient's risk of death. Histologically determined microcirculation patterns have also been found to sub-classify uveal melanoma and predict patient's risk of death. This study e...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：AIM:To review published literature concerning cataract surgery and dry eye disease (DED). METHODS:A search was undertaken using the following: PubMed (all years), Web of Science (all years), Ovid MEDLINE(R) (1946 to 12 December 2019), Ovid MEDLINE(R) Daily Update 10 December 2019, MEDLINE and MEDLINE non-indexed items...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1177/1120672120929958
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To report on phototherapeutic keratectomy (PTK) in myopic patients who developed spontaneous recurrent corneal erosions (RCE) following IntraLASIK. METHODS:Recurrent corneal erosions developed spontaneously 3-6 months following IntraLASIK in 4 eyes of 4 myopic patients. Diffuse lamellar keratitis (DLK) subsequ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000097
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:Traumatic eye injuries due to large foreign bodies (FB) are rare. The visual prognosis is often poor in these cases because of severe ocular damage. Staged surgical procedures with eventual enucleation or evisceration are often indicated. METHODS:Case series. RESULTS:The authors describe two patients with eye...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300413
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:To present the results of a retrospective comparative unicentric institutional study of the incidence of postcataract surgery endophthalmitis before and after the introduction of the European Society of Cataract and Refractive Surgeons (ESCRS) protocol in 2007 in our department. METHODS:This study included 15,...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000417
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:To describe a new technique to split the lens nucleus inside the capsular bag, using a novel pair of instruments. METHODS:Two identical instruments are employed on the horizontal axis to promote nuclear splitting into 2 or more fragments. Each instrument has a portion that functions as a hook (H); an anterior ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000567
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:To describe a patient who developed diplopia, lagophthalmos and exposure keratopathy due to a large subconjunctival emphysema. METHODS:A 24-year-old man sustained an injury in his left eye from a compressed air hose. The patient complained of pain and diplopia. He underwent slit-lamp examination, funduscopy an...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300113
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To describe a case of intraocular lens opacification resembling pseudophakic pseudoexfoliation affecting an AkreosFit intraocular lens (IOL). METHODS:Single case analysis. RESULTS:A patient had IOL opacification resembling pseudophakic pseudoexfoliation. CONCLUSIONS:An 83-year-old woman with normal tension g...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:To report a case of a combined branch retinal artery and vein occlusion in a patient with hepatitis C treated with interferon and ribavirin. METHODS:A 29-year-old man with a 1-week history of sudden visual field defect and decrease of central visual acuity was examined. RESULTS:Ophthalmoscopy and fluorescein ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2008.4623
更新日期：2005-01-01 00:00:00
abstract：:Copper intraocular foreign bodies (IOFB) are relatively common after penetrating eye injuries. Ocular signs and symptoms vary greatly in relation to the copper content, ranging from chronic uveitis and severe visual loss for IOFB containing more than 85% copper, to local copper deposits with no severe ocular damage fo...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Age-related macular degeneration is a condition (a) characterized by accumulation of membranous debris on both sides of the retinal pigment epithelium (RPE) basement membrane. Clinical manifestations of drusen, atrophy of the RPE/choriocapillaris, RPE detachment, and choroidal new vessel (CNV) formation occur after ag...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：PURPOSE:To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. METHODS:Interventional case report and literature search. RESULTS:A 9-year-old female patient with a disseminated disease showed comp...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119832187
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. METHODS:Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence o...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119862505
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To compare 2 different application methods of mitomycin C (MMC) in patients undergoing trabeculectomy. METHODS:This retrospective trial compared outcomes of 191 eyes that underwent trabeculectomy with small-area (96 eyes; 50.3%) and large-area (95 eyes; 49.7%) MMC application. Main outcome measures were chang...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000287
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To describe the impact that social media usage has on a group of retina specialists. MATERIALS AND METHODS:An anonymous online survey was sent to members of the Young Retina Forum who use the social media platform - Telegram. RESULTS:Of a total of 178 members, 100 responded (87 men and 13 wom...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119832186
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To describe the surgical interventions in congenital pupillary-iris-lens membrane. Six patients with congenital pupillary-iris-lens membrane presented with partial or totally occluded pupils, or increased intraocular pressure (IOP). METHODS:We describe the value of creating 2 paracenteses. The first one is mad...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.7734
更新日期：2011-09-01 00:00:00
abstract：PURPOSE:To report clinical and confocal microscopy features of late-onset Candida albicans keratitis after Descemet stripping automated keratoplasty (DSAEK). METHODS:We performed clinical and confocal scan on a patient who underwent DSAEK and phacoemulsification for Fuchs endothelial dystrophy and cataract. RESULTS:A...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.6228
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:To report the off-label use of systemic bevacizumab in a patient with stage 3 retinal angiomatous proliferation (RAP) associated with a vascularized pigmented epithelium detachment (PED). METHODS:Interventional case report. RESULTS:The patient was treated with systemic bevacizumab after obtaining fully inform...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700621
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:Cataract formation represents a serious problem in the elderly, and has a large impact on healthcare budget. The oxidative stress form and intensity might determine the cataract type and pigmentation, making efforts in the cataract prevention challenge more complex. METHODS:This is a retrospective cross-sectio...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210801800501
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:Malignant melanoma associated with a blue nevus is a rare diagnosis. Additionally, only a handful of cases of malignant melanoma associated with blue nevi involving the ocular structures have been reported. We report a probable case of malignant melanoma associated with a blue nevus with metastasis to multiple ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.6375
更新日期：2011-09-01 00:00:00
abstract：PURPOSE:To report a case of bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. METHODS:A 61-year-old man with POEMS syndrome had bilateral anterior optic neuropathy and unilat...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210901900129
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To illustrate the successful outcome of pars plana vitrectomy (PPV) with melphalan irrigation for vitreous hemorrhage (VH) with suspected viable retinoblastoma. Despite the high risk of intraocular surgery, it was performed to preserve the only potentially seeing eye with treated retinoblastoma. METHODS:Vitreo...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000683
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:To review and analyze the epidemiological profile, clinical characteristics and visual outcomes in patients attended for traumatic open globe injury (OGI) at our hospital over a 5-year period. DESIGN:Retrospective chart review study. METHODS:Retrospective analysis of all patients attended at Fundación Jiménez...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120962039
更新日期：2020-10-10 00:00:00
abstract：PURPOSE:To emphasize the demographic and occupational characteristics of ophthalmologists primarily involved in retinopathy of prematurity (ROP) care and to ascertain their practices and preferences. METHODS:A questionnaire was sent to all Turkish ophthalmologists known to be primarily involved in ROP. They were asked...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000272
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Lowe syndrome is a rare X-linked disease that is characterized by renal dysfunction, developmental delays, congenital cataracts and glaucoma. Mutations in the oculocerebral renal syndrome of Lowe (OCRL) gene are found in Lowe syndrome patients. Although loss of vision is a major concern for families and phys...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120920544
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:We aimed to discuss the possible role of developmental embryologic factors in neural crest cells in the aetiology of keratoconus and Fuchs' heterochromic iridocyclitis by presenting this case. CASE REPORT:We diagnosed bilateral keratoconus and unilateral Fuchs' heterochromic iridocyclitis in a 19 year old wome...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210101100114
更新日期：2001-01-01 00:00:00
abstract：PURPOSE:The authors wondered whether the spectrum of endophthalmitis and the type of therapy had changed. METHODS:Files of patients who were operated upon for endophthalmitis between 1988 and 2000 were retrospectively analyzed. They were divided into Group 1 (operated upon 1988 to 1994) and Group 2 (1995 to 2000). RE...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600217
更新日期：2006-03-01 00:00:00
