Abstract：
SIGNIFICANCE:Susac's syndrome is a rare retinocochleocerebral immune-mediated endotheliopathy and clinically manifests as a pathognomonic triad of encephalopathy, hearing loss, and branch retinal artery occlusion. This triad is rarely present at symptom onset, thus, it is often initially misdiagnosed. To date, Susac's syndrome has persisted as an elusive entity and there are numerous treatment regimens proposed with varying effectiveness mainly based on case series. PURPOSE:To report our 12-month follow-up experience in the treatment of Susac's syndrome with rituximab. CASE REPORT:A 25-year-old female presenting with headache, paresthesias, tinnitus, peripheral vertigo, and a branch retinal artery occlusion. The patient had a personal history of anxiety-depressive disorder. After discarding other infectious/autoimmune conditions and magnetic resonance imaging suggestive findings of Susac's syndrome, we observed a prompt response to the combination of intravenous immunoglobulin, corticosteroids, and rituximab. CONCLUSION:A standard treatment paradigm is lacking in Susac's syndrome as randomized controlled trials do not exist. There are no definitive scores to predict its outcome, and early diagnosis is important as the organs involved can easily become irreversibly damaged. Thus, patients with Susac's syndrome must be treated promptly and aggressively. Our report highlights the possibility of positive long-term prognosis with an early use of rituximab. However, a systematic therapeutic approach on the basis of controlled trials is mandatory to develop a consensus.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Monferrer-Adsuara C,Remolí-Sargues L,Hernández-Bel L,Gracia-García A,Hernández-Garfella ML,Cervera-Taulet Edoi
10.1177/1120672120924545subject
Has Abstractpub_date
2020-05-07 00:00:00pages
1120672120924545eissn
1120-6721issn
1724-6016pub_type
杂志文章abstract：PURPOSE:To assess the safety and efficacy of hybrid vitreous surgery combining active 23-G ports with a sutured 20-G 6-mm infusion cannula for performing vitrectomy in endophthalmitis and trauma. METHODS:This is a retrospective analysis of 10 eyes with endophthalmitis and 10 eyes with trauma requiring vitreous surgery...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000988
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abstract：PURPOSE:To evaluate the choroidal vascularity index of eyes for acute and chronic central serous chorioretinopathy patients using swept-source optical coherence tomography generated en-face scans. METHODS:This was a retrospective study, in which slabs of en-face optical coherence tomography scans, at 5 μm intervals, s...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120908719
更新日期：2020-02-27 00:00:00
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
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更新日期：2019-06-12 00:00:00
abstract：PURPOSE:To analyze results of amniotic membrane transplantation (AMT) in treatment of corneal ulceration after severe chemical and thermal injuries. METHODS:Analysis of 55 AMT in 53 patients (53 eyes) with corneal ulceration and limbal deficiency 180-360° of the limbus after grade 4-6 (Dua classification, 2001) chemic...
journal_title：European journal of ophthalmology
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更新日期：2013-07-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210501500109
更新日期：2005-01-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2011-09-01 00:00:00
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journal_title：European journal of ophthalmology
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journal_title：European journal of ophthalmology
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doi：
更新日期：2009-11-01 00:00:00
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journal_title：European journal of ophthalmology
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更新日期：2014-01-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章,多中心研究
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更新日期：2013-11-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210801800405
更新日期：2008-07-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
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journal_title：European journal of ophthalmology
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更新日期：2015-01-01 00:00:00
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journal_title：European journal of ophthalmology
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更新日期：2014-11-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：PURPOSE:To evaluate the effect of IOP lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with primary open angle glaucoma. METHODS:Twenty eyes of 14 glaucomatous patients and 15 eyes of nine normal patients were enrolled. The most appropriate hypotonic treatment was applied...
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pub_type： 杂志文章,meta分析
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更新日期：2020-07-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-11-01 00:00:00
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更新日期：2012-09-01 00:00:00
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journal_title：European journal of ophthalmology
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更新日期：2018-09-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of symmetric bilateral medial rectus recession in large-angle esotropic Duane retraction syndrome (DRS) with moderate to severe globe retraction. METHODS:In a retrospective study, medical reports of 30 patients with esotropia of equal or more than 20 prism diopters (pd) and moderate to...
journal_title：European journal of ophthalmology
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更新日期：2020-11-04 00:00:00
abstract：PURPOSE:To evaluate epithelial healing and visual outcome after laser-assisted subepithelial keratectomy (LASEK) without alcohol de-epithelialization and to compare this technique to photorefractive keratectomy (PRK) in myopia. METHODS:In a series of 1953 patients undergoing bilateral myopic PRK, an epithelial flap co...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1177/112067210301300802
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:To asses visual quality after bilateral implantation of the Acri.LISA 366D intraocular lens (IOL) (Carl Zeiss Meditec) in patients with high and low-moderate myopia. METHODS:A total of 304 eyes of 152 patients had bilateral implantation of the Acri.LISA 366D IOL. The patients were divided into 2 groups: low-mo...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000111
更新日期：2010-01-01 00:00:00
