Abstract:
OBJECTIVE:To investigate the potential correlation between complement factor B polymorphisms and age-related macular degeneration. METHODS:We retrieved relevant articles systematically by searching PubMed and Web of Science databases. The pooled odds ratios and 95% confidence intervals were calculated for five complement factor B polymorphism rs641153, rs4151667, rs1048709, rs2072633, and rs12614 using data from included articles in both random effects and fixed effect models. Subgroup meta-analysis based on age-related macular degeneration type, choroidal neovascular disease (rs641153 and rs4151667), geographic atrophy (rs641153 and rs4151667), and races was also performed. RESULTS:In the overall comparison, we observed that the distribution of rs641153 and the risk of age-related macular degeneration were significantly correlated (p < 0.00001). Similar results were obtained in subgroup analysis based on race (Caucasians, p < 0.00001; Asians, p = 0.003) and age-related macular degeneration type (choroidal neovascular disease, p < 0.00001; geographic atrophy, p = 0.04). As for complement factor B rs4151667, the genotypic effects were also demonstrated statistically significant in overall analysis (p < 0.00001) and only in Caucasians diagnosed with choroidal neovascular disease (p = 0.004), but not in Asians. Moreover, no statistically significant correlations between the complement factor B polymorphisms rs1048709 (p = 0.63), rs2072633 (p = 0.72), rs12614 (p = 0.98) and susceptibility to age-related macular degeneration were detected in either overall or subgroup analysis. CONCLUSION:Collectively, we demonstrated that the complement factor B genes rs641153 and rs4151667, but not rs1048709, rs2072633, rs12614, were associated with the susceptibility of age-related macular degeneration and might play predictive roles in future age-related macular degeneration diagnosis. More studies are needed to verify these findings.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Su Y,Hu Z,Pan T,Chen L,Xie P,Liu Qdoi
10.1177/1120672119840245subject
Has Abstractpub_date
2020-07-01 00:00:00pages
743-755issue
4eissn
1120-6721issn
1724-6016journal_volume
30pub_type
杂志文章,meta分析abstract:PURPOSE:Traumatic eye injuries due to large foreign bodies (FB) are rare. The visual prognosis is often poor in these cases because of severe ocular damage. Staged surgical procedures with eventual enucleation or evisceration are often indicated. METHODS:Case series. RESULTS:The authors describe two patients with eye...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300413
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To assess efficacy, safety, and predictability after refractive lens exchange (RLE) in patients who had bilateral implantation of an Acri.LISA 366D diffractive bifocal intraocular lens (IOL). METHODS:Sixty-six eyes of 33 consecutive patients were examined after RLE who had bilateral implantation of an Acri.LIS...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.2010.2991
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:To report the first case of bilateral ocular decompression retinopathy after uneventful non-perforating deep sclerectomy with mitomycin C in a child with tubulointerstitial nephritis and uveitis syndrome. CASE DESCRIPTION:An 8-year-old girl affected by tubulointerstitial nephritis and uveitis syndrome dev...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672119832177
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To compare retinal nerve fiber layer thickness (RNFLT) and inner macula thickness changes measured with Fourier-domain optical coherence tomography (FD-OCT) and scanning laser polarimetry during the course of acute optic neuritis (ON). METHODS:Nine eyes of 7 consecutive patients with multiple sclerosis (MS) we...
journal_title:European journal of ophthalmology
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doi:10.5301/EJO.2010.5844
更新日期:2011-07-01 00:00:00
abstract:PURPOSE:To assess the role of risk factors for amblyopia, such as family history and neonatal background, for the prediction of either strabismic amblyopia or refractive amblyopia. METHODS:In this retrospective case-control model, the study population included all children born at the Hospital de Braga during 1997-201...
journal_title:European journal of ophthalmology
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更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To estimate the prevalence of lens opacities in a group of elderly people and evaluate their relation with diverse risk factors. METHODS:Cross-sectional observational study of the cohort of all persons over the age of 64 years from an urban area and a rural nucleus of the province of Cuenca, Spain. Information...
journal_title:European journal of ophthalmology
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doi:10.1177/112067210701700105
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journal_title:European journal of ophthalmology
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更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To evaluate the use of the resorbable polylactic acid polymer implants (Resorb X) in the management of orbital floor blow-out fractures as regards safety, cosmetic, and functional results. METHODS:In a prospective, interventional case series, 22 patients with traumatic blow-out floor fractures underwent lower ...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672120928005
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journal_title:European journal of ophthalmology
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abstract::Indocyanine green video-angiography (ICG) was done twice on three patients with choroidal osteoma. Choroidal osteoma consisted of two portions, a yellow-white area and a surrounding orange area. The early phase of ICG angiography showed hypofluorescence due to blockage, corresponding to the osteoma. However, the hypof...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600405
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. METHODS:Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence o...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119862505
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:To compare the efficacy of selective laser trabeculoplasty (SLT) to argon laser trabeculoplasty (ALT) as treatment and retreatment to lower intraocular pressure (IOP) in patients with uncontrolled open-angle glaucoma (OAG) on maximally tolerated medication therapy with a follow-up of 12 months. METHODS:A total...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067210901900317
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To examine the nature and frequency of ocular side effects due to systemic target therapy with BRAF and MEK inhibitors as well as immunotherapy with cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death 1 (PD-1) monoclonal antibodies used in the treatment of cutaneous malignant melanoma (CMM). DE...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120930688
更新日期:2020-05-31 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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abstract:PURPOSE:To describe a case of a 46-year-old woman with an asymptomatic history of unilateral multiple serous detachments of the retinal pigment epithelium (PED) in the right eye, treated with photodynamic therapy (PDT) with verteporfin for recent onset of subfoveal choroidal neovascularization (CNV) with chorioretinal ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2004-11-01 00:00:00
abstract::Purpose. To compare long-term variability of retinal nerve fiber layer thickness (RNFLT) measurements made with the RTVue-100 Fourier-domain optical coherence tomograph (RTVue-OCT) and scanning laser polarimetry with variable (GDx-VCC) and enhanced (GDx-ECC) corneal compensation. Methods. One eye each of 110 Caucasian...
journal_title:European journal of ophthalmology
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doi:10.5301/ejo.5000178
更新日期:2013-01-21 00:00:00
abstract:PURPOSE:To describe the long-term clinical course of patients with low-pressure glaucoma (LPG) and to assess the risk factors for disease progression. METHODS:The Wills Eye Glaucoma Research Center retrospectively reviewed the charts of LPG patients with documented follow-up of >8 years between 2000 and 2013. Medical ...
journal_title:European journal of ophthalmology
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更新日期:2015-11-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life. METHODS:A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year peri...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672119862878
更新日期:2020-11-01 00:00:00
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672119858891
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:To report on the microperimetric evaluation of the central visual field in a patient with retinopathy due to membranoproliferative glomerulonephritis. METHODS:The central 20 degrees visual field was evaluated using fundus-related perimetry with (Nidek MP1) microperimeter in a patient with proven membranoprolif...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600425
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:Anthrax is a rare infection transmitted to humans from animals or animal products. In cutaneous anthrax it may produce lesions of the eyelids which can lead to cicatricial ectropion. METHODS:We examined three women and five men with anthrax of the eyelids. Intravenous penicillin G was used alone as therapy. R...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210101100212
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Retinitis punctata albescens is a form of retinitis pigmentosa characterized by white fleck-like deposits in the fundus, in most cases caused by pathogenic variants in RLBP1 gene. The purpose of this work is to report the phenotypic and genotypic data of a patient with retinitis punctata albescens carrying a...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672120919064
更新日期:2020-04-28 00:00:00
abstract:PURPOSE:Ocular toxoplasmosis is associated with vitreoretinal complications that can potentially cause severe visual loss. The aim of this study is to report the preoperative, intraoperative, and postoperative outcomes of vitreous surgery in eyes with vitreoretinal complications secondary to ocular toxoplasmosis. METH...
journal_title:European journal of ophthalmology
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doi:
更新日期:2009-11-01 00:00:00
abstract:PURPOSE::To evaluate the use of intraocular injection of triamcinolone acetonide in pediatric cataract surgery with or without intraocular lens implantation as a vitreous dye to ensure a complete anterior vitrectomy and evaluate its effect on postoperative ocular inflammation, infection, posterior capsule opacification...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/1120672117754168
更新日期:2018-11-01 00:00:00
abstract::A 62-year-old female developed pseudophakic bullous keratopathy after cataract surgery and underwent Descemet stripping automated endothelial keratoplasty (DSAEK). Intraoperatively, a white opacified pre-Descemet's layer was noticed after scoring and removal of trypan blue stained Descemet's membrane (DM), and endothe...
journal_title:European journal of ophthalmology
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更新日期:2020-11-30 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To report the results of corneal collagen crosslinking (CXL) in a patient with corneal ectasia developed after excimer laser-assisted lamellar keratoplasty for keratoconus and a secondary photorefractive keratectomy (PRK) for residual refractive error. METHODS:A 33-year-old woman, who had originally been treat...
journal_title:European journal of ophthalmology
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更新日期:2012-03-01 00:00:00