Abstract:
PURPOSE:To compare retinal nerve fiber layer thickness (RNFLT) and inner macula thickness changes measured with Fourier-domain optical coherence tomography (FD-OCT) and scanning laser polarimetry during the course of acute optic neuritis (ON). METHODS:Nine eyes of 7 consecutive patients with multiple sclerosis (MS) were prospectively imaged from the onset of ON for 6 to 12 months. Nine healthy eyes were imaged for 12 to 19 months. RESULTS:Retinal nerve fiber layer thickness measured with FD-OCT initially increased in all eyes with diffuse optic disc edema. Inner macula thickness and polarimetric RNFLT decreased already in the acute phase, in all eyes. All parameters stabilized at 2 to 5 months. The relative structural loss was different with the different methods. Poor image quality with polarimetry occurred in 2 eyes in the acute phase of ON. In the control eyes all parameters were stable. CONCLUSIONS:Change of RNFLT and macular thickness during the course of acute ON in MS strongly depends on the method used for the measurement. Inner macula thickness, measured with FD-OCT, was especially useful for the follow-up, since it was not influenced by initial disc edema and had consistently high image quality.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Garas A,Simó M,Holló Gdoi
10.5301/EJO.2010.5844subject
Has Abstractpub_date
2011-07-01 00:00:00pages
473-83issue
4eissn
1120-6721issn
1724-6016pii
C24F7753-9C5F-4B13-AF56-61EDD66783D3journal_volume
21pub_type
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