Abstract:
PURPOSE:To identify a new cortical vitreous segmentation protocol for non invasive standardised investigation of Neovascularisation (NV) with detection of regression of NV activity in Proliferative Diabetic Retinopathy (PDR). DESIGN:Retrospective study. PARTICIPANTS:One hundred and eighty-six eyes of 93 consecutive diabetic patients (mean age: 52.6 ± 11.0 years) imaged using Topcon Triton® Swept-Source Optical Coherence Tomography Angiography (SS-OCTA) from June 2015 to January 2017. METHODS:Scans were performed through the macula, optic disc and areas of possible NV in mid-peripheral retina using 6 × 6 mm and/or 9 × 9 mm raster-patterns in three segmentation protocols: Vitreo-Retinal (VRS), Outer-Vitreous (OVS) and Core-Vitreous Segmentation (CVS). Any suspicion of PDR was confirmed in all patients by Heidelberg® Widefield-Fundus-Fluorescein-Angiography (WF-FFA) and/or Optos® Ultra-WF-FFA (UWF-FFA). Inter-observer reproducibility of NV diagnosis and agreement between SS-OCTA and UWF-FFA were assessed. Primary outcome was the identification of an effective and reproducible segmentation protocol. Secondary outcome was the identification of NV regression after treatment. RESULTS:Sensitivity-specificity reached, respectively, the value of 100 to 100 in detecting NVD, and 96.6 to 100 in detecting NVE in compared areas. SS-OCTA was able to confirm absence of blood flow within the residual NV plexus when using VRS protocol in 30 eyes in which regression of NV with absence of leakage was documented on FFA. CONCLUSION:Three segmentation protocols (VRS, OVS and CVS) with different but complementary characteristics, allowed a reproducible and standardised investigation of NVD and NVE. The proposed new SS-OCTA cortical vitreous segmentation protocols may be of value when identifying and assessing NV-activity (VRS, OVS and CVS) or NV-regression (VRS) in PDR and therefore, response to therapy.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Papayannis A,Tsamis E,Stringa F,Iacono P,Battaglia Parodi M,Stanga PEdoi
10.1177/1120672120944028subject
Has Abstractpub_date
2020-07-28 00:00:00pages
1120672120944028eissn
1120-6721issn
1724-6016pub_type
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of ophthalmology
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doi:
更新日期:1998-04-01 00:00:00
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journal_title:European journal of ophthalmology
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doi:10.5301/EJO.2008.3552
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abstract:PURPOSE:To report on phototherapeutic keratectomy (PTK) in myopic patients who developed spontaneous recurrent corneal erosions (RCE) following IntraLASIK. METHODS:Recurrent corneal erosions developed spontaneously 3-6 months following IntraLASIK in 4 eyes of 4 myopic patients. Diffuse lamellar keratitis (DLK) subsequ...
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pub_type: 临床试验,杂志文章,随机对照试验
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