Swept-source optical coherence tomography angiography vitreo-retinal segmentation in proliferative diabetic retinopathy.

Abstract:

PURPOSE:To identify a new cortical vitreous segmentation protocol for non invasive standardised investigation of Neovascularisation (NV) with detection of regression of NV activity in Proliferative Diabetic Retinopathy (PDR). DESIGN:Retrospective study. PARTICIPANTS:One hundred and eighty-six eyes of 93 consecutive diabetic patients (mean age: 52.6 ± 11.0 years) imaged using Topcon Triton® Swept-Source Optical Coherence Tomography Angiography (SS-OCTA) from June 2015 to January 2017. METHODS:Scans were performed through the macula, optic disc and areas of possible NV in mid-peripheral retina using 6 × 6 mm and/or 9 × 9 mm raster-patterns in three segmentation protocols: Vitreo-Retinal (VRS), Outer-Vitreous (OVS) and Core-Vitreous Segmentation (CVS). Any suspicion of PDR was confirmed in all patients by Heidelberg® Widefield-Fundus-Fluorescein-Angiography (WF-FFA) and/or Optos® Ultra-WF-FFA (UWF-FFA). Inter-observer reproducibility of NV diagnosis and agreement between SS-OCTA and UWF-FFA were assessed. Primary outcome was the identification of an effective and reproducible segmentation protocol. Secondary outcome was the identification of NV regression after treatment. RESULTS:Sensitivity-specificity reached, respectively, the value of 100 to 100 in detecting NVD, and 96.6 to 100 in detecting NVE in compared areas. SS-OCTA was able to confirm absence of blood flow within the residual NV plexus when using VRS protocol in 30 eyes in which regression of NV with absence of leakage was documented on FFA. CONCLUSION:Three segmentation protocols (VRS, OVS and CVS) with different but complementary characteristics, allowed a reproducible and standardised investigation of NVD and NVE. The proposed new SS-OCTA cortical vitreous segmentation protocols may be of value when identifying and assessing NV-activity (VRS, OVS and CVS) or NV-regression (VRS) in PDR and therefore, response to therapy.

journal_name

Eur J Ophthalmol

authors

Papayannis A,Tsamis E,Stringa F,Iacono P,Battaglia Parodi M,Stanga PE

doi

10.1177/1120672120944028

subject

Has Abstract

pub_date

2020-07-28 00:00:00

pages

1120672120944028

eissn

1120-6721

issn

1724-6016

pub_type

杂志文章
  • Two nonsense mutations of PAX6 in two Japanese aniridia families: case report and review of the literature.

    abstract:PURPOSE:To identify PAX6 mutations in patients from four Japanese families with aniridia. METHODS:Polymerase chain reaction (PCR)-single stand conformational polymorphism (SSCP) analysis (SSCA) was performed in probands of the families, and restriction analysis using MaeIII or AvaI was carried out in other affected fa...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1177/112067210001000213

    authors: Kondo-Saitoh A,Matsumoto N,Sasaki T,Egashira M,Saitoh A,Yamada K,Niikawa N,Amemiya T

    更新日期:2000-04-01 00:00:00

  • Favorable long-term results of primary pterygium removal by bare sclera extirpation followed by a single 90Strontium application.

    abstract:PURPOSE:To describe and compare long-term (> or = 36 months) effects of patients with 86 primary pterygia treated with bare sclera extirpation (BSE) followed by Beta-RT or by sham irradiation. METHODS:Prospective, multicenter, randomized, double-blind study. After BSE of their pterygium, patients were randomized to ei...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/112067210801800301

    authors: Mourits MP,Wyrdeman HK,Jurgenliemk-Schulz IM,Bidlot E

    更新日期:2008-05-01 00:00:00

  • Amniotic membrane transplantation in treatment of persistent corneal ulceration after severe chemical and thermal eye injuries.

    abstract:PURPOSE:To analyze results of amniotic membrane transplantation (AMT) in treatment of corneal ulceration after severe chemical and thermal injuries. METHODS:Analysis of 55 AMT in 53 patients (53 eyes) with corneal ulceration and limbal deficiency 180-360° of the limbus after grade 4-6 (Dua classification, 2001) chemic...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000243

    authors: Iakimenko SA,Buznyk OI,Rymgayllo-Jankowska B

    更新日期:2013-07-01 00:00:00

  • Modified Y- split and recession of medial rectus muscles in convergence excess esotropia.

    abstract:PURPOSE:The convergence excess esotropia (CEET) is defined when near esotropia is greater than the distance by at least 10 PD while the eye is corrected with the full cycloplegic refraction. The purpose of this study is to evaluate the effect of a modified technique of Y- split recession of the medial rectus muscles on...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120965494

    authors: Bagheri A,Abbasnia E,Tavakoli M

    更新日期:2020-10-23 00:00:00

  • Factors predisposing to postoperative intraocular inflammation.

    abstract::This prospective study of 123 patients undergoing cataract extraction determined the preoperative and surgical factors predisposing to an exaggerated postoperative inflammatory response. It is important to identify the patients at increased risk of complications requiring additional prophylaxis or more intensive posto...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Corbett MC,Hingorani M,Boulton JE,Shilling JS

    更新日期:1995-01-01 00:00:00

  • Resorbable polylactic acid polymer plates in repair of blow-out orbital floor fractures.

    abstract:PURPOSE:To evaluate the use of the resorbable polylactic acid polymer implants (Resorb X) in the management of orbital floor blow-out fractures as regards safety, cosmetic, and functional results. METHODS:In a prospective, interventional case series, 22 patients with traumatic blow-out floor fractures underwent lower ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120928005

    authors: Esmail MEK,Ibrahiem MFK,Abdallah RMA,Elshafei AMK,Gawdat TI

    更新日期:2020-05-31 00:00:00

  • SD-OCT stages of progression of type 2 macular telangiectasia in a patient followed for 3 years.

    abstract:PURPOSE:To describe the natural course of type 2 idiopathic macular telangiectasia (MT) using spectral-domain optical coherence tomography (SD-OCT). METHODS:Analysis of the different stages of progression of type 2 MT during a period of 3 years using multimodal imaging, including SD-OCT correlated with angiographic an...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000363

    authors: Coscas G,Coscas F,Zucchiatti I,Bandello F,Soubrane G,SouÏed E

    更新日期:2013-11-01 00:00:00

  • Large subconjunctival emphysema causing diplopia and lagophthalmos.

    abstract:PURPOSE:To describe a patient who developed diplopia, lagophthalmos and exposure keratopathy due to a large subconjunctival emphysema. METHODS:A 24-year-old man sustained an injury in his left eye from a compressed air hose. The patient complained of pain and diplopia. He underwent slit-lamp examination, funduscopy an...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210301300113

    authors: Kaiserman I

    更新日期:2003-01-01 00:00:00

  • Quantitative evaluation of anterior chamber changes after iridotomy using Pentacam anterior segment analyzer.

    abstract:PURPOSE:To evaluate changes in anterior chamber morphology with the Pentacam anterior segment analyzer and gonioscopy after laser peripheral iridotomy (LPI) in patients with primary angle closure glaucoma and narrow angle and to compare central corneal thickness measurements performed with Pentacam and ultrasound pachy...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067211002000211

    authors: López-Caballero C,Puerto-Hernández B,Muñoz-Negrete FJ,Rebolleda G,Contreras I,Cabarga C,Corral A

    更新日期:2010-03-01 00:00:00

  • Lincoff temporary balloon buckle in retinal detachment surgery.

    abstract:PURPOSE:To assess the long-term anatomical and functional results of balloon buckle surgery for rhegmatogenous retinal detachment. PATIENTS AND METHODS:Twenty-five selected detachments with a single break or a group of breaks close together were treated with a temporary parabulbar balloon. Adhesion was obtained with t...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210101100410

    authors: Oge I,Birinci H,Havuz E,Kaman A

    更新日期:2001-10-01 00:00:00

  • Late-onset Candida keratitis after Descemet stripping automated endothelial keratoplasty: clinical and confocal microscopic report.

    abstract:PURPOSE:To report clinical and confocal microscopy features of late-onset Candida albicans keratitis after Descemet stripping automated keratoplasty (DSAEK). METHODS:We performed clinical and confocal scan on a patient who underwent DSAEK and phacoemulsification for Fuchs endothelial dystrophy and cataract. RESULTS:A...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/EJO.2011.6228

    authors: Ortiz-Gomariz A,Higueras-Esteban A,Gutiérrez-Ortega ÁR,González-Méijome JM,Arance-Gil A,Villa-Collar C

    更新日期:2011-07-01 00:00:00

  • Screening for glaucoma in a general population with the non-mydriatic fundus camera and the frequency doubling perimeter.

    abstract:PURPOSE:To evaluate the usefulness of non-mydriatic fundus camera (NMFu-camera) and frequency doubling perimeter (FDP) for detecting glaucoma in a general population. METHODS:This prospective observational multicenter study consisted in screening for glaucoma in the populations of three Belgian cities. Intraocular pre...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/112067210401400505

    authors: Detry-Morel M,Zeyen T,Kestelyn P,Collignon J,Goethals M,Belgian Glaucoma Society.

    更新日期:2004-09-01 00:00:00

  • A comparison of topical mequitazine and disodium cromoglycate in allergic conjunctivitis induced by a specific conjunctival provocation test.

    abstract:PURPOSE:Twenty-two people with a history of grass pollen allergic conjunctivitis were enrolled outside the pollen season in this study to compare the efficacy of 0.05% mequitazine eyedrops with topical 2% disodium cromoglycate. METHODS:This randomized, double-blind study compared right and left eyes. Subjects received...

    journal_title:European journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/112067210001000103

    authors: Dupin O,Trinquand C,Persi L,Bousquet J,Robert F,Arnaud B

    更新日期:2000-01-01 00:00:00

  • Ocular and orbital complications following the treatment of retinoblastoma.

    abstract:PURPOSE:To investigate the ocular and orbital complications observed in children treated for retinoblastoma. SUBJECTS AND METHODS:We retrospectively studied 73 children (39 boys, 34 girls) suffering from retinoblastoma. Thirty-six had bilateral tumor and 37 unilateral disease for a total of 109 eyes affected. The foll...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Anteby I,Ramu N,Gradstein L,Miskin H,Pe'er J,Benezra D

    更新日期:1998-04-01 00:00:00

  • Definition of indicators of appropriateness in the management of neovascular age-related macular degeneration: An expert opinion.

    abstract::Wet age-related macular degeneration is a chronic condition culminating, in most cases, in blindness. The introduction of anti-angiogenic agents in 2006 has represented a major breakthrough in the treatment of the disease, but timely and effective treatment with regular follow-up and monitoring is mandatory to stabili...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1177/1120672120915685

    authors: Avitabile T,Boscia F,Dell'Erba A,Introini U,Lanzetta P,Locatelli P,Ricci F,Staurenghi G,Varano M,Zotti F

    更新日期:2020-07-01 00:00:00

  • Late onset posttraumatic Propionibacterium acnes endophthalmitis.

    abstract:PURPOSE:To report a case of late onset posttraumatic endophthalmitis secondary to Propionibacterium acnes infection. METHODS:Interventional case report. RESULTS:A 28-year-old man developed endophthalmitis 6 months after a penetrating trauma. The patient underwent pars plana lensectomy and vitrectomy along with inject...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/EJO.2008.3552

    authors: Abu El-Asrar AM,Al-Obeidan SA,Yeboah EA

    更新日期:2004-01-01 00:00:00

  • Bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with POEMS syndrome.

    abstract:PURPOSE:To report a case of bilateral non-simultaneous optic neuropathy and unilateral macular edema in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. METHODS:A 61-year-old man with POEMS syndrome had bilateral anterior optic neuropathy and unilat...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210901900129

    authors: Gutierrez-Ortiz C,Castro-Rebollo M,Pareja J,Beckford C,Teus M

    更新日期:2009-01-01 00:00:00

  • Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy.

    abstract:PURPOSE:To report on phototherapeutic keratectomy (PTK) in myopic patients who developed spontaneous recurrent corneal erosions (RCE) following IntraLASIK. METHODS:Recurrent corneal erosions developed spontaneously 3-6 months following IntraLASIK in 4 eyes of 4 myopic patients. Diffuse lamellar keratitis (DLK) subsequ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/ejo.5000097

    authors: Kremer I

    更新日期:2012-01-01 00:00:00

  • Laser-assisted in situ keratomileusis long term outcomes in late adolescence.

    abstract:PURPOSE:Evaluate the long term outcomes of myopic-LASIK in a late adolescent population (age ⩾17 and <20 at the time of surgery). METHODS:Monocentric retrospective case series study. Eyes with at least 3 years of follow-up time were included. Primary outcome measures were long term efficacy, safety and stability of th...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120969039

    authors: Alió Del Barrio JL,Canto-Cerdán M,Bo M,Subirana N,Alió JL

    更新日期:2020-10-30 00:00:00

  • Comparison of clinical results between heparin surface modified hydrophilic acrylic and hydrophobic acrylic intraocular lens.

    abstract:PURPOSE:To compare the clinical results of heparin surface modified (HSM) hydrophilic acrylic intraocular lens (IOL) with those of hydrophobic acrylic IOL. METHODS:One hundred patients with cataract were randomized to receive one of acrylic foldable IOLs after phacoemulsification: HSM hydrophilic acrylic IOL (n=50) Bi...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/112067210801800311

    authors: Kang S,Kim MJ,Park SH,Joo CK

    更新日期:2008-05-01 00:00:00

  • Determining size and characteristics of metal intraocular foreign bodies using helical CT scan.

    abstract:PURPOSE:To carry out a pilot study comparing the size of various types of metallic intraocular foreign bodies as imaged on computed tomographic (CT) scan to their actual size, and to determine the features of different types of metals on CT scan. METHODS:Metallic foreign bodies of predetermined standardized sizes were...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210901900528

    authors: Briscoe D,Geffen N,Assia EI,Yaffe D

    更新日期:2009-09-01 00:00:00

  • Multimodal imaging of pre-Descemet corneal dystrophy.

    abstract:PURPOSE:The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. METHODS:Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence o...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672119862505

    authors: Alafaleq M,Georgeon C,Grieve K,Borderie VM

    更新日期:2020-09-01 00:00:00

  • Reliability of preoperative ultrasonography evaluation for vitreoretinal surgery.

    abstract::To evaluate the present level of reliability of common ultrasonography prior to vitreoretinal surgery, we carried out a prospective study to compare preoperative ultrasonography data with direct intraoperative findings. A total of 228 eyes with different vitreoretinal disorders and opaque or clear media were studied. ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Azzolini C,Pierro L,Candino M,Brancato R

    更新日期:1994-04-01 00:00:00

  • Pre-operative conjunctival flora in patients with local and/or systemic risk factors for post cataract surgery infection in Northern Italy.

    abstract:PURPOSE:To investigate the pre-operative conjunctival flora in patients undergoing cataract surgery with major local and/or systemic risk factors for developing post-operative infection. METHODS:A total of 83 patients underwent bacterial culture and sensitivity testing of conjunctival swabs obtained from both eyes bec...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672120934991

    authors: Bruttini C,Pallone C,Verticchio Vercellin A,Acerbi G,Baschetti S,Bruttini P,Riva I,Quaranta L

    更新日期:2020-06-19 00:00:00

  • Treatment of acute bacterial conjunctivitis with topical lomefloxacin 0.3% compared to topical ofloxacin 0.3%.

    abstract:PURPOSE:The main purpose of this prospective study was to compare the efficacy, local tolerance, and safety of topical lomefloxacin 0.3% and topical ofloxacin 0.3% in the treatment of acute bacterial conjunctivitis. PATIENTS AND METHODS:Forty patients with acute bacterial conjunctivitis were included in a randomized, ...

    journal_title:European journal of ophthalmology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Tabbara KF,El-Sheikh HF,Islam SM,Hammouda E

    更新日期:1999-10-01 00:00:00

  • Pseudophakic pseudoexfoliation of an AkreosFit intraocular lens.

    abstract:PURPOSE:To describe a case of intraocular lens opacification resembling pseudophakic pseudoexfoliation affecting an AkreosFit intraocular lens (IOL). METHODS:Single case analysis. RESULTS:A patient had IOL opacification resembling pseudophakic pseudoexfoliation. CONCLUSIONS:An 83-year-old woman with normal tension g...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:

    authors: Roberts MA,Hawksworth NR

    更新日期:2009-11-01 00:00:00

  • Oculofacial alterations in NBAS-SOPH like mutations: Case report.

    abstract:PURPOSE:To describe the clinical features of a rare case of NBAS-SOPH-like mutations; to emphasize special aspects of the ocular and oro-facial regions. METHODS:Case report. CASE DESCRIPTION:We present a 5-year-old girl initially examined for her dysmorphic features, mental delay, strabismus, and high myopia. During ...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672119836335

    authors: Nucci F,Lembo A,Farronato M,Farronato G,Nucci P,Serafino M

    更新日期:2020-03-01 00:00:00

  • Ocular hypotensive effects of cholinergic and adrenergic drugs may be influenced by prostaglandins E2 in the human and rabbit eye.

    abstract:PURPOSE:Increased PGE2 production by the iris and ciliary body regulate intraocular pressure (IOP) in vivo. Various cholinergic and adrenergic compounds are traditionally used as antiglaucoma drugs, and their effect on IOP reduction is antagonised by cyclooxygenase inhibitors, indicating a role for eicosanoids in their...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/112067210301300103

    authors: Kaplan-Messas A,Naveh N,Avni I,Marshall J

    更新日期:2003-01-01 00:00:00

  • The effect of insulin pump therapy in retinal vasculature in type 1 diabetic patients.

    abstract:BACKGROUND/OBJECTIVES:Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vascul...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1177/1120672121990576

    authors: de Oliveira Loureiro T,Cardoso JN,Lopes CDPL,Carreira AR,Rodrigues-Barros S,Vide-Escada A,Campos NP

    更新日期:2021-01-26 00:00:00

  • Transient vitreomacular traction syndrome caused by traumatic incomplete posterior vitreous detachment.

    abstract:PURPOSE:To report transient vitreomacular traction (VMT) syndrome following acute blunt trauma associated with incomplete posterior vitreous detachment. METHODS:The authors present the analysis of 2 eyes of consecutive patients with acute VMT following mild blunt trauma. Both patients reported a sudden decrease in vis...

    journal_title:European journal of ophthalmology

    pub_type: 杂志文章

    doi:10.5301/EJO.2011.6425

    authors: Lorusso M,Micelli Ferrari L,Leozappa M,Modoni AP,Micelli Ferrari T

    更新日期:2011-09-01 00:00:00