Abstract:
PURPOSE:Increased PGE2 production by the iris and ciliary body regulate intraocular pressure (IOP) in vivo. Various cholinergic and adrenergic compounds are traditionally used as antiglaucoma drugs, and their effect on IOP reduction is antagonised by cyclooxygenase inhibitors, indicating a role for eicosanoids in their hypotensive activity. One of the most potent antiglaucoma drugs, PG2 alpha (Latanoprost), reduces IOP by increasing uveoscleral outflow and also increases PGE2 production by the iris and ciliary body in vivo. We investigated whether cholinergic and adrenergic antiglaucoma drugs induce the production of prostaglandin E2 (PGE2) in vitro by: 1) the iris-ciliary body (ICB) of rabbits and, 2) irises of glaucoma patients. METHODS:Pilocarpine 2%, epinephrine 1% and echothiophate iodide 0.125% were applied topically to both eyes of Albino rabbits. Control groups were treated with the corresponding vehicles, or untreated completely. Human iris specimens were obtained from nine untreated cataract eyes, and five eyes under antiglaucoma medication undergoing surgery. PGE2 were determined by a radioimmunoassay. RESULTS:PGE2 production by the ICB of treated rabbits in vitro was twice that of vehicle-treated or untreated rabbit eyes (p<0.001, for either group). In vitro PGE2 production by treated glaucoma patients' irises was three times higher (p<0.001) than in cataract control patients. CONCLUSIONS:The study found an increase in in vitro production of PGE2 by the irises of eyes treated with cholinergic and adrenergic antiglaucoma medications. This suggests a role for endogenous PG production in the hypotensive effect of both classes of drug.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Kaplan-Messas A,Naveh N,Avni I,Marshall Jdoi
10.1177/112067210301300103subject
Has Abstractpub_date
2003-01-01 00:00:00pages
18-23issue
1eissn
1120-6721issn
1724-6016journal_volume
13pub_type
杂志文章abstract::Purpose. To record the information used in order to make a retreatment decision in patients with exudative age-related macular degeneration (AMD) and to assess if an optical coherence tomography (OCT)-only follow-up clinic would suffice. Methods. Two hundred patients under treatment with intravitreal anti-vascular end...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000190
更新日期:2012-08-06 00:00:00
abstract:PURPOSE:To evaluate changes at the anterior chamber angle during Valsalva maneuver in eyes suspected to have a primary adult glaucoma. METHODS:Seventy-six consecutive patients underwent recording of applanation tonometry, measurement of the anterior chamber angle recess, angle opening distance, angle recess area, scle...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600114
更新日期:2006-01-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2020-07-28 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900518
更新日期:2009-09-01 00:00:00
abstract::Bruch's membrane, an extracellular matrix located between the retinal pigment epithelium and the choroid, plays a vital role as structural and functional support to the retinal pigment epithelium. Dysfunction of Bruch's membrane in both age-related macular degeneration and other ocular diseases is caused mostly by ext...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672120919337
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:The aim of this study is to evaluate the incidence, natural course, and distribution pattern of superficial punctate keratopathy and describe the changes in signs and symptoms of dry eye after cataract surgery. SETTING:The setting of this study is University Hospital Rio Hortega and Instituto Universitario de ...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672119896427
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journal_title:European journal of ophthalmology
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更新日期:2006-09-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200202
更新日期:2002-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of ophthalmology
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更新日期:2007-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1177/112067210501500204
更新日期:2005-03-01 00:00:00
abstract::Non-arteritic anterior ischemic optic neuropathy (NAION) is characterized by the progressive and irreversible death of retinal ganglion cells (RGCs) which is caused by the insufficient blood supply to the optic nerve (ON) head. At present, hormone therapy is used to reduce optic edema, followed by nerve nutrition ther...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120974283
更新日期:2020-11-21 00:00:00
abstract:BACKGROUND/OBJECTIVES:The aim of this article was to study the lower punctum parameters in patients with acquired punctal stenosis using spectral-domain anterior segment optical coherence tomography. SUBJECTS/METHODS:This was a prospective nonrandomized study that included two groups. Group 1 was composed of 32 puncta...
journal_title:European journal of ophthalmology
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doi:10.1177/1120672119871396
更新日期:2019-09-06 00:00:00
abstract:PURPOSE:To report a case of posterior uveitis with retinal neovascularization in a patient with Behçet disease treated with infliximab. METHODS:A 50-year-old man with a history of recurrent relapses of ocular inflammation despite immunosuppressive therapy developed retinal neovascularization near the optic disk. The p...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::The objectives of this study were two-fold: to identify tear histamine content and its relationship to changes in tear histaminase activity during the early (EPR) and late phases (LPR) of the allergic reaction induced by a conjunctival provocation test (CPT) and to evaluate the effects of lodoxamide on histamine relea...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-04-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210001000203
更新日期:2000-04-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120907317
更新日期:2020-02-16 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2013-01-21 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-03-01 00:00:00
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journal_title:European journal of ophthalmology
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更新日期:2009-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700328
更新日期:2007-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of intravitreal dexamethasone implant in treatment naïve eyes with diabetic macular edema (DME). METHODS:A retrospective analysis of treatment naïve eyes with DME which received intravitreal dexamethasone implant between January 2016 and March 2018 was done. Demographic deta...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2020-08-10 00:00:00
abstract:INTRODUCTION:Preretinal hemorrhages can be located in subhyaloid or sub-internal limiting membrane (ILM) space. Though optical coherence tomography (OCT) may help to distinguish the exact location of hemorrhage in selected cases, it is often difficult to discern clinically. The purpose is to describe a novel clinical s...
journal_title:European journal of ophthalmology
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更新日期:2020-06-22 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1177/112067210301300802
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:To review the current practice of retreatment with Ozurdex injections in patients with macular edema (ME) secondary to retinal vein occlusion (RVO), and to recommend simple guidelines for Ozurdex reinjection in management of RVO. METHODS:This was a multicenter retrospective study of patients who received more ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.5301/ejo.5000376
更新日期:2014-01-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119894887
更新日期:2020-11-01 00:00:00