Abstract:
PURPOSE:To compare the inhibitory effects of a topical combination product, cromolyn sodium (DSCG) 4% with the antihistamine, chlorpheniramine, with those of topical ketotifen 0.05% on the clinical allergic reaction induced by the conjunctival allergen challenge (CAC). METHODS:Ten allergic but non-active patients were challenged in both eyes with increasing doses of specific allergen to obtain a positive bilateral reaction (visit 1). They were then rechallenged after 1 week to confirm the allergic threshold dose response (visit 2). After 2 weeks, a third CAC was performed bilaterally 30 minutes after topical application of DSCG-chlorpheniramine in one eye and ketotifen in the contralateral eye in a double-masked fashion (visit 3). Clinical signs and symptoms were registered 5, 10, 15, and 20 minutes after challenge using the standard scoring system. Tear cytology was performed 30 minutes after challenge. RESULTS:Comparing the two drug effects at visit 3, DSCG-chlorpheniramine was shown to be superior to ketotifen at all time points for itching (p < 0.01) and at 5 minutes for redness (p < 0.01). For the total signs score, DSCG-chlorpheniramine was shown to be superior to ketotifen at all time points (p < 0.01), and at 10 and 15 minutes for the total symptoms score (p < 0.05). Compared to visit 2, DSCG-chlorpheniramine significantly lowered itching (p < 0.001) and redness (p < 0.05) at 5, 10, 15, and 20 minutes after challenge. Ketotifen significantly lowered itching at 5 and 10 minutes (p < 0.001) and redness at 5, 10, and 15 minutes (p < 0.05). Both drugs reduced the total number of cells evaluated by tear cytology during the early-phase reaction (p < 0.05). CONCLUSIONS:DSCG-chlorpheniramine was found to be more effective than ketotifen at preventing itching and redness in the CAC model.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Leonardi A,Busca F,Tavolato M,Secchi AGdoi
10.1177/112067210301300202subject
Has Abstractpub_date
2003-03-01 00:00:00pages
128-33issue
2eissn
1120-6721issn
1724-6016journal_volume
13pub_type
临床试验,杂志文章,随机对照试验abstract:PURPOSE:To study the correlation between final visual acuity after successful anatomic macular hole repair and features on spectral domain optical coherence tomography (SD-OCT). METHODS:Retrospective review of charts of patients who underwent macular hole surgery. Data collection included pre- and postoperative best-c...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000306
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:To assess the frequency of pseudoexfoliation syndrome (PEX) and evaluate its association with specific ocular diseases in patients attending the Department of Ophthalmology at Gaziosmanpasa University Hospital. METHODS:A prospective study was conducted at the Gaziosmanpasa University Hospital between December ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000621
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To describe the use of silicone oil (SO) in combination with subretinal recombinant tissue plasminogen activator (rtPA) to achieve dislocation of large subretinal hemorrhage secondary to exudative age-related macular degeneration (AMD). METHODS:A single-eye 81-year-old woman, known for exudative AMD, presented...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120952349
更新日期:2020-08-18 00:00:00
abstract::Indocyanine green video-angiography (ICG) was done twice on three patients with choroidal osteoma. Choroidal osteoma consisted of two portions, a yellow-white area and a surrounding orange area. The early phase of ICG angiography showed hypofluorescence due to blockage, corresponding to the osteoma. However, the hypof...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1994-10-01 00:00:00
abstract:PURPOSE:To describe a case of bilateral eyelid-confined giant cell angiofibroma (GCAF) in a patient with a slowly progressive bilateral eyelid swelling. METHODS:A 40-year-old man with a 5-year history of slowly progressive bilateral eyelid swelling, severe functional impairment, and bilateral cosmetic deformity was st...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000608
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To report a case of a combined branch retinal artery and vein occlusion in a patient with hepatitis C treated with interferon and ribavirin. METHODS:A 29-year-old man with a 1-week history of sudden visual field defect and decrease of central visual acuity was examined. RESULTS:Ophthalmoscopy and fluorescein ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.4623
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To report a case series of anterior uveitis after Transepithelial Photorefractive Keratectomy (TransPRK) and determine its incidence, demographics and associated clinical features over a study period of 1 year. METHODS:This retrospective case series comprised of 200 eyes (100 patients) which underwent elective...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120974946
更新日期:2020-11-25 00:00:00
abstract:OBJECTIVE:To identify complications associated with tumor-related lipid exudation (TRLE) after plaque radiotherapy of posterior uveal melanoma. METHODS:Comparative study including 294 patients with posterior uveal melanoma who developed TRLE after plaque radiotherapy (TRLE group) and 294 patients who did not develop ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000236
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To report clinical findings and surgical management of 4 patients with congenital nystagmus who presented with a new or reversal of their original horizontal compensatory head posture (CHP) after Anderson-Kestenbaum (A-K) surgery. METHOD:Retrospective chart review. RESULTS:All 4 patients demonstrated a 40°-45...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.8356
更新日期:2012-03-01 00:00:00
abstract::Considerable improvement has been achieved in the way in which exudative age-related macular degeneration is conventionally treated and in the associated visual outcomes and prognosis, thanks to the agents with effects against vascular endothelial growth factor (anti-VEGF). By comparison to earlier treatment approache...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672119832432
更新日期:2019-07-01 00:00:00
abstract:PURPOSE:To evaluate visual performance after implantation of a new diffractive aspheric multifocal intraocular lens (MIOL) with a +3.50 D addition power. METHODS:A total of 24 cataract patients were bilaterally implanted with the Diffractiva-aA MIOL in 2 ophthalmologic centers and followed for 6 months. Postoperative ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.5301/ejo.5000315
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To evaluate perioperative changes in blood coagulation in patients undergoing retinal detachment surgery. MATERIALS:Prospective study of 56 patients, aged from 19 to 82 (mean +/- S.D. 53 +/- 16.8) years, undergoing retinal detachment surgery (encirclement with scleral buckling) under general anesthesia. Exclud...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210001000408
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:The prognosis of visual acuity (VA) after branch retinal vein occlusion (BRVO) in patients with diabetes mellitus is unknown compared to the VA in non-diabetic patients with BRVO. The aim of this study was to evaluate the visual outcome of BRVO in diabetic and non-diabetic patients. METHODS:A retrospective cas...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1177/112067210301300709
更新日期:2003-08-01 00:00:00
abstract:PURPOSE:To report on a case of episcleral hemangioma in a child. METHODS:A 3-year-old boy presented with a 4-week history of limbal mass in the left eye and had an excision of that mass. RESULTS:There was an 8 x 7 mm oval lesion, 3-4 mm below the inferior limbus. It was reddish, sharply elevated with smooth surface, ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900220
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To investigate the low mesopic contrast sensitivity function (LMCSF) of patients implanted with different modern optical bifocal and trifocal designs of multifocal intraocular lenses (mfIOLs). METHODS:This prospective, comparative, nonrandomized consecutive case series included 180 eyes that underwent cataract...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000777
更新日期:2016-11-04 00:00:00
abstract:PURPOSE:To evaluate the efficacy of 3 different surgical techniques for convergence excess esotropia: augmented medial rectus recession, medial rectus recession plus Faden, and slanted medial rectus recession. METHODS:Twenty-nine patients with convergence excess esotropia were divided into 3 groups. Group A included 9...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.2010.5225
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To describe the safety and efficacy of intravitreal tissue plasminogen activator (tPA) and sulfur hexafluoride (SF6) gas with sequential photodynamic therapy (PDT) in the management of submacular hemorrhage (SMH) associated with macular degeneration (MD). METHODS:Consecutive case series of five patients presen...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800415
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:This study deals with the role of the topical administration of dorzolamide eyedrops on the oxidative/antioxidant status of aqueous humor in patients with primary open angle glaucoma (POAG). METHODS:A case-control study including 130 patients distributed into three groups was carried out: 1) patients with POAG...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900408
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To report the off-label use of systemic bevacizumab in a patient with stage 3 retinal angiomatous proliferation (RAP) associated with a vascularized pigmented epithelium detachment (PED). METHODS:Interventional case report. RESULTS:The patient was treated with systemic bevacizumab after obtaining fully inform...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700621
更新日期:2007-11-01 00:00:00
abstract::Purpose. To investigate the sensitivity and specificity of machine learning classifiers (MLC) and spectral domain optical coherence tomography (SD-OCT) for the diagnosis of glaucoma. Methods. Sixty-two patients with early to moderate glaucomatous visual field damage and 48 healthy individuals were included. All subjec...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000183
更新日期:2012-06-15 00:00:00
abstract:PURPOSE:Among the 500 ABCA4 mutations identified so far in the retina-specific ABC transporter (ABCA4) gene, only 20 have been described in patients with autosomal recessive retinitis pigmentosa (arRP). In this study the gene was screened for mutations in a cohort of 25 patients of Spanish origin, to further assess ABC...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700510
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:To investigate the ocular and orbital complications observed in children treated for retinoblastoma. SUBJECTS AND METHODS:We retrospectively studied 73 children (39 boys, 34 girls) suffering from retinoblastoma. Thirty-six had bilateral tumor and 37 unilateral disease for a total of 109 eyes affected. The foll...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:PURPOSE:Intravitreal implantation of dexamethasone implant (Ozurdex®) is being widely used for the treatment of macular edema (ME) after branch or central retinal vein occlusion, diabetic ME, and persistent ME associated with uveitis or Irvine-Gass syndrome. We describe a complication: migration of the dexamethasone im...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000715
更新日期:2016-04-12 00:00:00
abstract:PURPOSE:Mutations in the ABCA4 gene result in a broad spectrum of severe retinal degeneration, including Stargardt macular dystrophy, fundus flavimaculatus, autosomal recessive retinitis pigmentosa, and cone-rod dystrophy. In addition to the detection of well-characterized mutations, genetic testing frequently yields n...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
abstract:PURPOSE:To compare the performance of two different microcatheter systems, iTrack™ 250A and Glaucolight, in ab externo canaloplasty in three major categories: intraocular pressure reduction, drug therapy reintroduction, and evaluation of viscodilation over distension of the inner wall of Schlemm's canal. METHODS:A tot...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119833547
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To determine the prevalence of symptoms of computer vision syndrome and to identify its associated factors. The secondary objective was to assess knowledge and practices related to preventing computer vision syndrome symptoms. METHODS:The data for this cross-sectional study were collected through a self-admini...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118815110
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life. METHODS:A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year peri...
journal_title:European journal of ophthalmology
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更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To evaluate the choroidal vascularity index of eyes for acute and chronic central serous chorioretinopathy patients using swept-source optical coherence tomography generated en-face scans. METHODS:This was a retrospective study, in which slabs of en-face optical coherence tomography scans, at 5 μm intervals, s...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120908719
更新日期:2020-02-27 00:00:00
abstract:PURPOSE:To describe a patient who developed diplopia, lagophthalmos and exposure keratopathy due to a large subconjunctival emphysema. METHODS:A 24-year-old man sustained an injury in his left eye from a compressed air hose. The patient complained of pain and diplopia. He underwent slit-lamp examination, funduscopy an...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300113
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To describe the clinical features of a rare case of NBAS-SOPH-like mutations; to emphasize special aspects of the ocular and oro-facial regions. METHODS:Case report. CASE DESCRIPTION:We present a 5-year-old girl initially examined for her dysmorphic features, mental delay, strabismus, and high myopia. During ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119836335
更新日期:2020-03-01 00:00:00