Abstract：
PURPOSE:To report on whole body positron emission tomography/computed tomography (PET/CT) screening for metastasis at diagnosis of primary uveal melanoma. METHODS:Since August 2003, 333 consecutive patients were diagnosed with uveal melanoma and underwent whole body screening for metastatic disease with PET/CT along with liver function tests and physical examination. Abnormal findings prompted further biopsies, blood tests, imaging, or clinical evaluations for confirmation. The presence of metastatic disease and second cancers were evaluated. RESULTS:Using the American Joint Committee on Cancer (AJCC) tumor, node, metastasis (TNM) 7th edition criteria, 104 tumors were classified T1 (31%), 162 T2 (49%), 37 T3 (11%), and 30 T4 (9%). Seven of 333 (2.1%; 95% confidence interval [CI] 0.8-4.3) patients had metastatic melanoma. One tumor was a T3 and 6 were T4. Thus, 3% of T3 and 20% of T4 melanomas were found to have metastases at the time of initial diagnosis. Ten patients (3.3%; 95% CI 0.9-5.5) had synchronous second cancers and 28 (8.4%) concurrent benign lesions. The most common metastatic sites were liver (7/7) and bone (2/7). DISCUSSION:This study suggests that PET/CT improves the yield of detecting both extrahepatic metastases, especially from tumors defined as AJCC-T4, and synchronous primary cancers, irrespective of the size of the uveal melanoma. With respect to liver metastases, PET/CT demonstrated high sensitivity and positive predictive values, indicating an overall better performance than conventional screening procedures.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Freton A,Chin KJ,Raut R,Tena LB,Kivelä T,Finger PTdoi
10.5301/ejo.5000049subject
Has Abstractpub_date
2012-03-01 00:00:00pages
236-43issue
2eissn
1120-6721issn
1724-6016pii
0034863E-660C-4695-B69B-A35409378156journal_volume
22pub_type
杂志文章abstract：PURPOSE:To report a case of extreme corneal flattening after initially uneventful Descemet stripping endothelial keratoplasty (DSEK). METHODS:A 76-year-old man underwent uneventful DSEK for pseudophakic bullous keratopathy (PBK) in his left eye. Postoperative evaluations were performed using anterior segment optical c...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000658
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:To investigate the pre-operative conjunctival flora in patients undergoing cataract surgery with major local and/or systemic risk factors for developing post-operative infection. METHODS:A total of 83 patients underwent bacterial culture and sensitivity testing of conjunctival swabs obtained from both eyes bec...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120934991
更新日期：2020-06-19 00:00:00
abstract：PURPOSE:To assess the influence of recipient corneal pathology on the performance of the Pascal dynamic contour tonometer (PDCT) (Swiss Microtechnology AG) by comparing it to Goldmann applanation tonometry (GAT) in post-penetrating keratoplasty (PKP) eyes. METHODS:Intraocular pressure (IOP) was measured in 40 post-PKP...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000104
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To report on the presence of 4 different structures visualized by confocal microscopy in patients whose clinical presentation suggested infection by Acanthamoeba. METHODS:Data and charts of 28 consecutive patients were analyzed in a retrospective study. Four types of structures were recognized by confocal micr...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000817
更新日期：2017-01-19 00:00:00
abstract：:Idiopathic macular holes have long been considered to be a stable, untreatable condition with little or no chance of spontaneous visual improvement. Within the last few years, surgical intervention has been developed for the management of idiopathic Stage 3 and Stage 4 holes. With pars plana vitrectomy surgery, at lea...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To report a corneal transplant complication associated with intracameral recombinant tissue plasminogen activator (rTPA) treatment of postoperative fibrin reaction. METHODS:In a 71-year-old patient, a triple procedure was performed for perforated rheumatic ulcer and secondary cataract. RESULTS:A dense band ke...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700328
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:To study the morphologic characteristics of the optic nerve (ON) by using an experimental model of knockout mice for the expression of the PTEN gene, mainly involved in cell cycle arrest, apoptosis control, and cell size regulation. METHODS:The eyeballs with the retrobulbar ON attached were obtained from 26-we...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2008.4510
更新日期：2006-05-01 00:00:00
abstract：PURPOSE:To evaluate the choroidal vascularity index of eyes for acute and chronic central serous chorioretinopathy patients using swept-source optical coherence tomography generated en-face scans. METHODS:This was a retrospective study, in which slabs of en-face optical coherence tomography scans, at 5 μm intervals, s...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120908719
更新日期：2020-02-27 00:00:00
abstract：:In 1958, Kearns and Sayre described a multisystem entity, now known as Kearns-Sayre syndrome (KSS). The syndrome is defined as exhibiting a triad of thus far unexplained degenerative conditions: progressive external ophthalmoplegia, retinal pigmentary degeneration, and heart block. Commonly accompanying findings inclu...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To present a new indicator that measures the sulci of the lacrimal lake of the eye according to the degrees of ocular abduction at which they vanish. This new approach will help determine the severity and progression of mucosal retraction in ocular surface diseases. METHODS:A total of 181 eyes of 94 healthy pe...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210101100303
更新日期：2001-07-01 00:00:00
abstract：:Blood flow in various tissues of the body shows spontaneous variations. The purpose of this study was to analyze variations over time in the blood flow of the optic nerve head. Blood flow was measured by the laser Doppler flowmeter (LDF) in 12 healthy volunteers, and analyzed by spectral Fourier analysis. The LDF tech...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：PURPOSE:Among the 500 ABCA4 mutations identified so far in the retina-specific ABC transporter (ABCA4) gene, only 20 have been described in patients with autosomal recessive retinitis pigmentosa (arRP). In this study the gene was screened for mutations in a cohort of 25 patients of Spanish origin, to further assess ABC...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700510
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:To describe the in vivo confocal microscopy corneal findings in a patient treated with gold sodium thiomalate. METHODS:A woman with rheumatoid arthritis who had been treated with gold sodium thiomalate for 32 years came to our center for an ophthalmologic examination about 5 years ago. Besides visual acuity, t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000421
更新日期：2010-07-01 00:00:00
abstract：PURPOSE:To report a case of posterior uveitis with retinal neovascularization in a patient with Behçet disease treated with infliximab. METHODS:A 50-year-old man with a history of recurrent relapses of ocular inflammation despite immunosuppressive therapy developed retinal neovascularization near the optic disk. The p...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：PURPOSE:Two cases with optic disc pit associated maculopathy, treated with vitrectomy surgery with internal limiting membrane peeling (ILM) and gas tamponade, are presented. METHODS:Interventional case reports. RESULTS:Two patients with serous macular detachment associated with a congenital optic pit underwent vitrec...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210901900230
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:To evaluate the effect of IOP lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with primary open angle glaucoma. METHODS:Twenty eyes of 14 glaucomatous patients and 15 eyes of nine normal patients were enrolled. The most appropriate hypotonic treatment was applied...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120967233
更新日期：2020-10-29 00:00:00
abstract：PURPOSE:Dacryocystorhinostomy (DCR) is the standard surgical treatment for adult nasolacrimal duct obstruction. There have been relatively few studies of closed nasolacrimal duct intubation in adults. The aim of this study was to determine rates of anatomic patency following this procedure. METHODS:The authors carried...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700402
更新日期：2007-07-01 00:00:00
abstract：PURPOSE:To describe a technique for suturing a luxated intraocular lens (IOL) in the vitreous cavity directly to the ciliary sulcus using intraocular slipknot without IOL extraction. DESIGN:Noncomparative interventional case series. MATERIALS AND METHODS:A three-port vitrectomy was performed in all cases. According t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300604
更新日期：2003-07-01 00:00:00
abstract：PURPOSE::To evaluate the use of intraocular injection of triamcinolone acetonide in pediatric cataract surgery with or without intraocular lens implantation as a vitreous dye to ensure a complete anterior vitrectomy and evaluate its effect on postoperative ocular inflammation, infection, posterior capsule opacification...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1177/1120672117754168
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To evaluate central macular thickness (CMT) after cataract surgery in selected groups of patients. METHODS:The study comprised 4 groups-patients with epiretinal membrane, patients with high myopia, patients with diabetes without retinopathy, and healthy subjects-who underwent phacoemulsification and intraocu...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000280
更新日期：2013-09-01 00:00:00
abstract：PURPOSE:We evaluate the functional and anatomic outcome after intravitreal ranibizumab treatment in patients with choroidal neovascularization (CNV) related to chronic central serous chorioretinopathy (CSC). METHODS:This is a small case series of 5 eyes with CNV associated with chronic CSC treated with intravitreal in...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000524
更新日期：2010-09-01 00:00:00
abstract：PURPOSE:Pterygium is an invasive and highly vascularized growth, thought to arise from activated and proliferating limbal epithelial stem cells. Epidemiologic studies have found the increase of active angiogenic and epithelial growth factors in pterygia, and implicated that these molecules could be involved directly or...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210801800104
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopathy. The aim of our study was to analyze effect of 1.25 mg of intravitreal Avastin on serum concentration of vascular endothelial growth factor (VEGF) in diabetic patients. METHODS:Participants were 10 diabetic pati...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000118
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:To determine the safety and efficacy of photodynamic therapy with verteporfin (V-PDT) in the treatment of exudative idiopathic polypoidal choroidal vasculopathy (IPCV) lesions that were not suitable for laser photocoagulation. METHODS:This was a prospective, open label study in two centers involving 30 consecu...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1177/112067210601600506
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To compare between mitomycin C alone, porcine extracellular matrix alone, and combined low dose mitomycin C with porcine extracellular matrix in term of efficacy and safety in phaco-trabeculectomy surgery. STUDY DESIGN:Prospective comparative. METHODS:Sixty eyes of 60 patients complaining of primary open angl...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120944339
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:Twenty-two people with a history of grass pollen allergic conjunctivitis were enrolled outside the pollen season in this study to compare the efficacy of 0.05% mequitazine eyedrops with topical 2% disodium cromoglycate. METHODS:This randomized, double-blind study compared right and left eyes. Subjects received...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1177/112067210001000103
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:To identify novel velocity waveform parameters of the ophthalmic artery and central retinal artery by computer-aided image processing of Doppler ultrasonography measurements, and to evaluate correlations between the waveform parameters and different demographics and disease severity of open-angle glaucoma ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119848259
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To verify the diagnostic value of closed chamber thermometry and humidity measurement in normal and dry eye patients. METHODS:In 20 patients (40 eyes) with dry eye and 20 normal sex- and age-matched controls (40 eyes), aged from 11 to 61 years (mean 37.52 yrs, standard deviation, (SD) 14.81) temperature was me...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210301300403
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:To describe the management with intracameral recombinant tissue plasminogen activator (rtPA) of severe fibrin effusion after phacoemulsification, and its prevention with sustained-release dexamethasone intravitreal implant. METHODS:A 59-year-old man with chronic HLA-B27-associated uveitis underwent phacoemulsi...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000442
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:Norrie disease (ND) is a rare X-linked recessive disorder characterized by congenital blindness, which is often associated with sensorineural hearing loss and mental retardation. X-linked familial exudative vitreoretinopathy (FEVR) is a hereditary disorder characterized by an abnormality of the peripheral retin...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067219900900312
更新日期：1999-07-01 00:00:00
