Optic nerve alterations in PTEN +/- mice.

Abstract:

PURPOSE:To study the morphologic characteristics of the optic nerve (ON) by using an experimental model of knockout mice for the expression of the PTEN gene, mainly involved in cell cycle arrest, apoptosis control, and cell size regulation. METHODS:The eyeballs with the retrobulbar ON attached were obtained from 26-week-old mice. By using morphologic and morphometric techniques, light and electron transmission microscopy, the ON characteristics were determined in two groups of mice: 1) 'wild type' mice as the control group (C-G; n=15), 2) heterozygous knockout mice (+/-) for the PTEN gene (PTEN-G; n=15). Glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP) were studied using Western blot and immunoblotting approaches. RESULTS:The ON cross-sectional area was significantly higher in the PTEN-G than in the C-G (p<0.001). The axon sizes in mutant animals were much larger than in wild-type mice (p<0.001). No significant differences were noticed between those groups regarding the number of axons forming the ON and the presence of intra-axonal degeneration, myelin sheath alterations, or axoplasm density. No differences were detected in developmental marker protein expression. CONCLUSIONS:The morphologic and morphometric results suggest that heterozygous PTEN knockout mice had hypertrophic ON without ultrastructural alterations.

journal_name

Eur J Ophthalmol

authors

Lopez-Sanchez E,Frances-Muoz E,Menezo JL,Pinazo-Duran MD

doi

10.5301/EJO.2008.4510

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

440-445

issue

3

eissn

1120-6721

issn

1724-6016

pii

F821DB05-06BE-4ED3-8733-774317D2B1A6

journal_volume

16

pub_type

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