Electrophysiological approaches for early detection of glaucoma.

Abstract:

PURPOSE:While elevated intraocular pressure (IOP) is a major risk factor for glaucoma, only about 1% of patients with 25 mmHg develop the condition each year. Since a sizeable proportion of the ganglion cells are already lost when the visual field losses are apparent, the aim is to identify patients with elevated IOP in whom glaucoma damage is incipient before visual field changes occur. METHODS:This report concerns early diagnosis of glaucoma with electrophysiological techniques, rather than with monitoring the disease using various available psychophysical and morphological methods. Visual electrophysiology offers a wide range of tools to assess function layer-by-layer along the visual pathway. Their clinical value for early detection of glaucoma will be discussed. The pattern electroretinogram (PERG), a direct functional indicator of retinal ganglion cell function, is markedly affected by glaucoma, and in longitudinal studies the PERG correctly indicated eyes at risk before manifest glaucoma occurred. CONCLUSIONS:Consequently, this report will concentrate on the PERG. Less proven, but promising measures like the "photopic negative response", the motion visually evoked potential (VEP) and the multifocal VEP will also be touched upon.

journal_name

Eur J Ophthalmol

authors

Bach M

doi

10.1177/112067210101102s05

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

S41-9

eissn

1120-6721

issn

1724-6016

journal_volume

11 Suppl 2

pub_type

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