Abstract:
PURPOSE:To investigate the efficacy of intravitreal dexamethasone implants (DEX) after anti-VEGF failure in retinal vein occlusion macular oedema. METHODS:Retrospective cohort study of DEX implant (0.7 mg) given after anti-VEGF 'failure'. Switch to DEX occurred if a ⩽ +5 ETDRS letter gain and ⩽20% reduction in central subfield thickness was present following ⩾6 consecutive anti-VEGF injections. The primary endpoint was VA change 30 days after DEX. Secondary outcomes were peak VA change, VA change at monthly timepoints, percentage achieving 15-letter gain, central subfield thickness (CST) and intraocular pressure (IOP). RESULTS:Sixty-two injections in 62 patients associated with 26% central retinal vein occlusion (CRVO) and 74% branch retinal vein occlusion (BRVO) were eligible. There was a modest, significant improvement in mean VA change at 30 days compared to baseline (+6 letters, 95% CI +2.2 to +9.1 letters, p < 0.01). DEX implant significantly improved mean peak VA change compared to preceding anti-VEGF by +18.1 letters in CRVO (p = 0.002) and +13.2 letters in BRVO (p < 0.0001). IOP peaked between 30 and 60 days following injection, with 31% of CRVO and 11% of BRVO patients experiencing an IOP ⩾ 25 mmHg. CONCLUSION:DEX implant provides useful rescue therapy in cases of anti-VEGF 'failure' for macular oedema following retinal vein occlusion, resulting in improved functional outcomes at 30 days.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Yap TE,Husein S,Miralles de Imperial-Ollero JA,Colizzi B,Cordeiro MF,Younis Sdoi
10.1177/1120672120978355subject
Has Abstractpub_date
2020-12-27 00:00:00pages
1120672120978355eissn
1120-6721issn
1724-6016pub_type
杂志文章abstract:PURPOSE:To assess signs of dry eye syndrome in keratoconic eyes following intracorneal ring segment (ICRS) implantation. PATIENT AND METHODS:Twenty eyes of 20 consecutive patients with keratoconus were assessed for tear film changes following ICRS implantation at 6 months postoperatively. Evaluated parameters included...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120958301
更新日期:2020-09-21 00:00:00
abstract:INTRODUCTION:Preretinal hemorrhages can be located in subhyaloid or sub-internal limiting membrane (ILM) space. Though optical coherence tomography (OCT) may help to distinguish the exact location of hemorrhage in selected cases, it is often difficult to discern clinically. The purpose is to describe a novel clinical s...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120934958
更新日期:2020-06-22 00:00:00
abstract:PURPOSE:To describe the long-term clinical course of patients with low-pressure glaucoma (LPG) and to assess the risk factors for disease progression. METHODS:The Wills Eye Glaucoma Research Center retrospectively reviewed the charts of LPG patients with documented follow-up of >8 years between 2000 and 2013. Medical ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000624
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:The purpose of this study is to test non-inferiority of a lower dose of crosslinked hyaluronic acid (CLHA) to a higher dose of carmellose eye drop in menopause patients receiving antidepressant treatments. METHODS:This prospective, double-blind, single-center study enrolled sixty female patients. Mean age was ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120972026
更新日期:2020-11-05 00:00:00
abstract::Astigmatic changes in three series of cataract surgical procedures were compared. The first two series comprised eyes having a manual extracapsular cataract extraction (ECCE) through a 12.0 mm or 8.0 mm incision and implant of a PMMA posterior chamber lens. The third series comprised eyes having phacoemulsification th...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:INTRODUCTION:To report the first case of bilateral ocular decompression retinopathy after uneventful non-perforating deep sclerectomy with mitomycin C in a child with tubulointerstitial nephritis and uveitis syndrome. CASE DESCRIPTION:An 8-year-old girl affected by tubulointerstitial nephritis and uveitis syndrome dev...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119832177
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Evaluate the long term outcomes of myopic-LASIK in a late adolescent population (age ⩾17 and <20 at the time of surgery). METHODS:Monocentric retrospective case series study. Eyes with at least 3 years of follow-up time were included. Primary outcome measures were long term efficacy, safety and stability of th...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120969039
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND/AIMS:To assess structural and functional outcomes of treatment with intravitreal aflibercept (®Eylea) for diabetic macular oedema in treatment-naïve patients. METHODS:Sixty-four eyes receiving intravitreal anti-vascular endothelial growth factor therapy were included in the data analysis of this retrospecti...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120925034
更新日期:2020-05-19 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000683
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To compare ocular findings in eyes with primary open-angle glaucoma (POAG) and exfoliation glaucoma (EG) at the time of diagnosis when identical diagnostic criteria for glaucoma were applied. METHODS:We conducted a study on records of 519 consecutive, unselected patients with chronic glaucoma filing for cost-f...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000516
更新日期:2015-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900230
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To identify complications associated with tumor-related lipid exudation (TRLE) after plaque radiotherapy of posterior uveal melanoma. METHODS:Comparative study including 294 patients with posterior uveal melanoma who developed TRLE after plaque radiotherapy (TRLE group) and 294 patients who did not develop ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000236
更新日期:2013-05-01 00:00:00
abstract:AIM:A multicentre, randomized, placebo-controlled double-masked study was conducted to assess the efficacy and safety of Rimexolone 1% eye drops in reducing inflammation after cataract surgery and intra-ocular lens implantation. METHODS:Rimexolone 1% (124 patients) or placebo (58 patients) was given, four times a day ...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1998-01-01 00:00:00
abstract::Purpose. To investigate the sensitivity and specificity of machine learning classifiers (MLC) and spectral domain optical coherence tomography (SD-OCT) for the diagnosis of glaucoma. Methods. Sixty-two patients with early to moderate glaucomatous visual field damage and 48 healthy individuals were included. All subjec...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000183
更新日期:2012-06-15 00:00:00
abstract:BACKGROUND/OBJECTIVES:Continuous subcutaneous insulin infusion (CSII) is a treatment for type 1 diabetes that improves metabolic control and reduces micro and macrovascular complications. The aim of this study was to compare the effect of CSII versus traditional multiple daily injections (MDI) therapy on retinal vascul...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672121990576
更新日期:2021-01-26 00:00:00
abstract:PURPOSE:To describe a rare presentation of pituitary apoplexy as unilateral abducens nerve palsy demonstrating the various presentations of the condition. METHODS:Case report. RESULTS:A 48-year-old man presented with isolated right abducens nerve palsy. Magnetic resonance imaging showed a large pituitary macroadenoma...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000136
更新日期:2010-01-01 00:00:00
abstract::A number of systemic medications are known to cause macular toxicity, and bull's eye maculopathy is caused by some of them like hydroxychloroquine and clofazimine. A 55-year-old female, known case of vitiligo with history of undergoing methoxsalen-ultraviolet A therapy, presented with painless defective vision in both...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120907317
更新日期:2020-02-16 00:00:00
abstract:PURPOSE:To report on the presence of 4 different structures visualized by confocal microscopy in patients whose clinical presentation suggested infection by Acanthamoeba. METHODS:Data and charts of 28 consecutive patients were analyzed in a retrospective study. Four types of structures were recognized by confocal micr...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000817
更新日期:2017-01-19 00:00:00
abstract::The risk factors for intraoperative and early postoperative complications were evaluated in 351 consecutive cataract operations at the Oulu University Hospital in 1990. Bleeding into the anterior chamber during the operation was recorded in 8.6%, zonular rupture in 6.6%, posterior capsular rupture in 5.4% and vitreous...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:To compare the inhibitory effects of a topical combination product, cromolyn sodium (DSCG) 4% with the antihistamine, chlorpheniramine, with those of topical ketotifen 0.05% on the clinical allergic reaction induced by the conjunctival allergen challenge (CAC). METHODS:Ten allergic but non-active patients were...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/112067210301300202
更新日期:2003-03-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1177/112067210501500303
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To study the morphologic characteristics of the optic nerve (ON) by using an experimental model of knockout mice for the expression of the P27(Kip1) gene, mainly involved in cell cycle arrest, apoptosis control, and retinoblastoma protein phosphorylation. METHODS:Eyeballs with the retrobulbar ON attached were ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700317
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure-lowering effect, the safety profile, and the success rate of the XEN45 Gel Stent (Allergan, Dublin, Ireland) in patients with pseudoexfoliative glaucoma. METHODS:Retrospective study conducted on patients with pseudoexfoliative glaucoma, with or without cataract, who underwe...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118795063
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To compare the outcomes after switching between bevacizumab and ranibizumab therapy due to poor treatment effect in neovascular age-related macular degeneration (AMD). METHODS:This is a retrospective review of patients with neovascular AMD with first treatment using intravitreal bevacizumab (group 1) or ranibi...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000480
更新日期:2015-01-01 00:00:00
abstract:PURPOSE::To describe the patterns of regression of choroidal melanoma after treatment with plaque brachytherapy. METHODS::Retrospective interventional case series including 170 consecutive patients treated with 103Pd eye plaque radiation for choroidal melanoma. Outcome measures were changes in tumor thickness, surface...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118776146
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to compare the outcomes of transepithelial photorefractive keratectomy (Trans-PRK) with femtosecond laser assisted in situ keratomileusis (FS-LASIK) for the correction of low to moderate myopia. METHODS:A retrospective cohort study design was used. The study group included pa...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120980346
更新日期:2020-12-14 00:00:00
abstract:PURPOSE:To evaluate the effects of levodopa and dopamine agonists on retinal nerve fiber layer using scanning laser ophthalmoscope. METHODS:Forty-four patients with the diagnosis of Parkinson disease and receiving levodopa or dopamine agonist monotherapy were included in this prospective study. The control group consi...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700520
更新日期:2007-09-01 00:00:00
abstract::A 6-year-old boy was referred to our hospital for sudden blurring vision in the left eye. An ophthalmological evaluation showed white endothelial keratic precipitates and increased intra-ocular pressure. To our knowledge, this is the first reported case of hypertensive uveitis in children under 10 years of age and we ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120954050
更新日期:2020-08-27 00:00:00
abstract:PURPOSE:While elevated intraocular pressure (IOP) is a major risk factor for glaucoma, only about 1% of patients with 25 mmHg develop the condition each year. Since a sizeable proportion of the ganglion cells are already lost when the visual field losses are apparent, the aim is to identify patients with elevated IOP i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/112067210101102s05
更新日期:2001-07-01 00:00:00
abstract:PURPOSE::To describe a case of Posterior Keratoconus (keratoconus posticus); its clinical condition, corneal, refractive response to intracorneal ring implantation (MyoRing), anterior segment optical coherence tomography findings; and micro incisional cataract surgery outcome. METHODS::Case report. RESULTS::The case ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118787436
更新日期:2019-01-01 00:00:00