Corneal endothelial cells' protection against thermal injury: influence of ophthalmic viscoelastic substances in experimental study on rabbits.

Abstract:

PURPOSE:To quantify the maximal level of temperature and the time the maximal temperature is achieved and correlate the temperature parameters to the mean rate of endothelial cell loss after standardized ultrasound delivery assisted with four viscoelastic substances or different temperature of balanced salt solution (BSS). METHODS:Thirty rabbits (60 eyes) were divided into six groups in which different viscoelastic substances or different temperature of BSS were used: Group 1, Viscoat; 2, Provisc; 3, soft shell technique; 4, Celoftal; 5, BSS 22 degrees C; and 6, BSS 4 degrees C. The same parameters of ultrasound energy were delivered by standard phaco tip introduced into pupillary plane. Thermocamera was employed for measurements of temperature parameters. Endothelium cell count was measured before surgery and 1 month postoperatively. RESULTS:Maximal level of temperature was measured as follows: Group 5, 27.85 +/- 0.52 degrees C; Group 2, 27.75 +/- 0.54 degrees C; Group 3, 27.74 +/- 0.46 degrees C; Group 4, 27.25 +/- 0.60 degrees C; Group 6, 26.81 +/- 0.34 degrees C; Group 1, 26.52 +/- 0.48 degrees C (p<0.05). The time the maximal temperature is achieved was statistically shorter in Groups 5 and 6: 4 seconds, 5 seconds, respectively, p<0.0001, as compared with Group 2 (30 seconds), Group 3 (40 seconds), Group 1 (45 seconds), and Group 4 (50 seconds). The mean rate of endothelial cell loss was calculated as follows: Group 1, 4.35%+/-2.55%; Group 2, 8.43%+/-5.2%; Group 3, 6.25%+/-4.20%; Group 4, 6.53%+/-4.65%; Group 5, 14.3%+/-3.85%; and Group 6, 8.78%+/-4.45%. CONCLUSIONS:Viscoelastic substances offer different levels of endothelial cell protection against temperature increase during phacoemulsification. The mean rate of endothelial cell loss correlates with the time the maximal temperature is achieved rather than with the value of maximal level of temperature. This implicates that surgical strategy should consider the choice of the most effective viscoelastic substances, particularly in difficult cases, e.g., hard nucleus, shallow anterior chamber, primary endothelial abnormality.

journal_name

Eur J Ophthalmol

authors

Jurowski P,Goś R,Owczarek G,Gralewicz GZ

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

674-9

issue

6

eissn

1120-6721

issn

1724-6016

journal_volume

15

pub_type

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