Ca(2+)-activated Cl- and K+ channels and their modulation by endothelin-1 in rat pulmonary arterial smooth muscle cells.

abstract：:It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function. The aims of this study were to compare and contrast three different mouse skeletal muscl...

journal_title：Experimental physiology

authors： Jacobs RA,Díaz V,Meinild AK,Gassmann M,Lundby C

更新日期：2013-04-01 00:00:00

abstract：:Aortic bodies are arterial chemoreceptors presumed to monitor blood O2 content by unknown mechanisms, in contrast to their well-studied carotid body counterparts, which monitor PO2 and /pH. We recently showed that rat aortic body chemoreceptors (type I cells), located at the left vagus-recurrent laryngeal nerve bifurc...

journal_title：Experimental physiology

authors： Piskuric NA,Zhang M,Vollmer C,Nurse CA

更新日期：2014-01-01 00:00:00

abstract：:After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety. Indeed, it is the modification of gut hormone secretion that is consid...

journal_title：Experimental physiology

authors： Parker HE,Gribble FM,Reimann F

更新日期：2014-09-01 00:00:00

abstract：:The role of endothelium in the decreased contraction to phenylephrine in aorta of pregnant Wistar rats has been studied. Contractions in response to phenylephrine were significantly decreased in aortic rings from pregnant rats compared to those from non-pregnant rats. Pretreatment of the rings with indomethacin did no...

journal_title：Experimental physiology

authors： Aloamaka CP,Ezimokhai M,Cherian T,Morrison J

更新日期：1993-05-01 00:00:00

abstract：:What is the topic of this review? This article presents emerging evidence for heightened carotid body chemoreflex activity as a major driver of sympathetic activation and hypertension in sleep apnoea patients. What advances does it heighlight? This article discusses the recent advances on cellular, molecular and epige...

journal_title：Experimental physiology

authors： Prabhakar NR

更新日期：2016-08-01 00:00:00

abstract：:A recent model predicted a local synovial circulation of extravascular fluid in which capillary filtrate entered a joint cavity and fluid simultaneously drained out of the cavity via intercellular pathways distant from capillaries. Here, solutions of albumin (10-250 g l-1) were infused continuously into the knee joint...

journal_title：Experimental physiology

authors： McDonald JN,Levick JR

更新日期：1992-05-01 00:00:00

abstract：:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...

journal_title：Experimental physiology

authors： Williamson JW,Fadel PJ,Mitchell JH

更新日期：2006-01-01 00:00:00

abstract：:Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compar...

journal_title：Experimental physiology

authors： Smith MW,Phillips AD

更新日期：1990-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does the muscle metaboreflex affect the ratio of left ventricular contraction/relaxation rates and does heart failure impact this relationship. What is the main finding and its importance? The effect of muscle metaboreflex activation on the ventricular relaxation...

journal_title：Experimental physiology

authors： Mannozzi J,Massoud L,Kaur J,Coutsos M,O'Leary DS

更新日期：2020-11-23 00:00:00

abstract：:Our aim was to analyse endothelial hypoxic preconditioning after hypoxia-reperfusion (HR). Endothelial functionality was analysed through the vasorelaxation responses to acetylcholine (Ach) and the level of serine1177 phosphorylated endothelial nitric oxide synthase (eNOS) (ser1177-eNOS) measured by Western blot in in...

journal_title：Experimental physiology

authors： Carrasco-Martín C,Alonso-Orgaz S,De la Pinta JC,Marques M,Macaya C,Barrientos A,González MM,García-Méndez A,Mateos-Cáceres PJ,Porres JC,Rico LA,López-Farré AJ

更新日期：2005-07-01 00:00:00

abstract：:Endothelium-dependent relaxation in response to histamine and ACh has been studied on precontracted aortic rings from control and salt-loaded Sprague-Dawley rats. Both ACh and histamine caused relaxation of the noradrenaline-induced precontraction only in the presence of the endothelium. The relaxation response to ACh...

journal_title：Experimental physiology

authors： Obiefuna PC,Sofola OA,Ebeigbe AB

更新日期：1991-01-01 00:00:00

abstract：:Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

journal_title：Experimental physiology

authors： Maughan RJ,Leiper JB,McGaw BA

更新日期：1990-05-01 00:00:00

abstract：:Exercise induces a marked increase in interleukin-8 (IL-8) mRNA and protein expression within skeletal muscle fibres. Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif. CXC chemokines with ELR motifs are potent angiogenic factors in vivo, and IL-8 has been shown to act as an a...

journal_title：Experimental physiology

authors： Frydelund-Larsen L,Penkowa M,Akerstrom T,Zankari A,Nielsen S,Pedersen BK

更新日期：2007-01-01 00:00:00

abstract：:The present study was designed to analyse the effects of aerobic exercise on the metabolic effects of alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight)(-1)) intraperitoneally (A rats). Vehicle-injected rats were used as controls (C rats). At 28 days old, some of the A rats were s...

journal_title：Experimental physiology

authors： de Oliveira CA,Luciano E,de Mello MA

更新日期：2005-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...

journal_title：Experimental physiology

authors： Spiller PF,da Silva CAA,Francescato HDC,Moraes DJA

更新日期：2020-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The role of the cerebral haemodynamic response to either normobaric or hypobaric hypoxia in people susceptible to acute mountain sickness (AMS) is still under debate. Prefrontal cortex near-infrared spectroscopy-derived parameters were monitored in normobaric hyp...

journal_title：Experimental physiology

authors： Manferdelli G,Marzorati M,Easton C,Porcelli S

更新日期：2021-01-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...

journal_title：Experimental physiology

authors： Silver J,Wadley G,Lamon S

更新日期：2018-08-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympa...

journal_title：Experimental physiology

authors： Osborn JW,Hendel MD,Collister JP,Ariza-Guzman PA,Fink GD

更新日期：2012-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Exercise for type 2 diabetes patients treated with insulin therapy involves the risk of hypoglycaemia. Dipeptidyl peptidase-4 (DPP-4) inhibitors can be effective in combination with exercise because they reduce the incidence of hypoglycaemia. We evaluated the eff...

journal_title：Experimental physiology

authors： Tanimura Y,Aoi W,Mizushima K,Higashimura Y,Naito Y

更新日期：2019-07-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：:The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...

journal_title：Experimental physiology

authors： Hongo K,White E,Orchard CH

更新日期：1995-09-01 00:00:00

abstract：:Converging lines of evidence from epidemiological studies and animal models now indicate that the origins of obesity and related metabolic disorders lie not only in the interaction between genes and traditional adult risk factors, such as unbalanced diet and physical inactivity, but also in the interplay between genes...

journal_title：Experimental physiology

authors： Taylor PD,Poston L

更新日期：2007-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...

journal_title：Experimental physiology

authors： Takahashi M,Nakamoto T,Matsukawa K,Ishii K,Watanabe T,Sekikawa K,Hamada H

更新日期：2016-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We present a new non-invasive medical technology, the inspired sine-wave technique, which involves inhalation of sinusoidally fluctuating concentrations of a tracer gas. The technique requires only passive patient cooperation and can monitor different cardiorespi...

journal_title：Experimental physiology

authors： Bruce RM,Phan PA,Pacpaco E,Rahman NM,Farmery AD

更新日期：2018-05-01 00:00:00

abstract：:Hypoglossal nerve activity (HNA) controls the position and movements of the tongue. In persons with compromised upper airway anatomy, sleep-related hypotonia of the tongue and other pharyngeal muscles causes increased upper airway resistance, or total upper airway obstructions, thus disrupting both sleep and breathing...

journal_title：Experimental physiology

authors： Brandes IF,Stettner GM,Mörschel M,Kubin L,Dutschmann M

更新日期：2011-05-01 00:00:00

abstract：:Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...

journal_title：Experimental physiology

authors： Shoemaker JK,Usselman CW,Rothwell A,Wong SW

更新日期：2012-12-01 00:00:00

abstract：:The neurohypophysial hormone vasopressin contributes to control of urine output and, while urine flow shows a clear daily rhythm, there has been debate as to whether this is true of neurohypophysial hormones. A study was performed on fifteen adult males, with a mean age of 25 years, over a 24 h period, nine blood samp...

journal_title：Experimental physiology

authors： Forsling ML,Montgomery H,Halpin D,Windle RJ,Treacher DF

更新日期：1998-05-01 00:00:00

abstract：:We recently reported that a higher percentage of type I fibres in vastus lateralis and a greater peak oxygen uptake (O2) were associated with a greater initial rise in O2 (O2 /W, where W is work rate) following the onset of heavy constant power output exercise (above the lactate threshold, LT). It was unclear if these...

journal_title：Experimental physiology

authors： Barstow TJ,Jones AM,Nguyen PH,Casaburi R

更新日期：2000-01-01 00:00:00

abstract：:In the present study, we tested the hypothesis that chronic intermittent hypoxia (CIH) produces changes in the autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed to 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They wer...

journal_title：Experimental physiology

authors： Braga VA,Soriano RN,Machado BH

更新日期：2006-11-01 00:00:00

abstract：:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (...

journal_title：Experimental physiology

authors： Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TL

更新日期：1998-09-01 00:00:00