The effect of mechanical loading on the response of rat ventricular myocytes to acidosis.

abstract：NEW FINDINGS:What is the central question of this study? What is the role of microRNA-424-5p (miR-424-5p) in aortic smooth muscle cells? How does miR-424-5p function as a suppressor of the inflammatory response? What is the main finding and its importance? Upregulation of miR-424-5p inhibits the inflammatory response i...

journal_title：Experimental physiology

authors： Li C,Zhang M,Dai Y,Xu Z

更新日期：2020-06-01 00:00:00

abstract：:Age is a primary risk factor for cardiovascular disease, and this is an increasingly important public health concern because of an increase in the absolute number and proportion of the population at an older age in many countries. A key component of cardiovascular ageing is reduced function of the vascular endothelium...

journal_title：Experimental physiology

authors： Gates PE,Strain WD,Shore AC

更新日期：2009-03-01 00:00:00

abstract：:Rats were submitted to 14 days of hindlimb suspension in order to examine the contractile and elastic properties of the soleus muscles under disuse conditions. The calcium/strontium activation properties, the maximal shortening velocity (V0), as well as the time behaviour of force transients following quick releases a...

journal_title：Experimental physiology

authors： Toursel T,Stevens L,Mounier Y

更新日期：1999-01-01 00:00:00

abstract：:The effects of microinjections of adenosine and an adenosine receptor antagonist into the rostral ventrolateral medulla (RVLM) on the cardiovascular changes associated with the defence reaction were investigated in anaesthetized rats. Responses to electrical and chemical stimulation in RVLM were determined in alpha-ch...

journal_title：Experimental physiology

authors： Thomas T,Spyer KM

更新日期：1996-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure. What is the main finding and its importance? Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mo...

journal_title：Experimental physiology

authors： Reynolds LJ,Chavan NR,DeHoff LB,Preston JD,Maddox HF,O'Brien JM,Armstrong DA,Marsit CJ,Pearson KJ

更新日期：2019-01-01 00:00:00

abstract：:An energy-rich diet leads to enhanced ruminal Na(+) absorption, which is associated with elevated plasma insulin-like growth factor 1 (IGF-1) levels and an increased number of IGF-1 receptors in rumen papillae. This study examined the in vitro effect of IGF-1 on Na(+) transport across the rumen epithelium of hay-fed s...

journal_title：Experimental physiology

authors： Shen Z,Martens H,Schweigel-Röntgen M

更新日期：2012-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the cellular and molecular determinants of increased risk for cardiovascular disease from prolonged sitting? What is the main finding and its importance? Prolonged sitting, independent of calf raise interruption strategies, decreases microparticle counts...

journal_title：Experimental physiology

authors： Evans WS,Hanson ED,Shill DD,Landers-Ramos RQ,Stoner L,Willey Q,Credeur DP,Prior SJ

更新日期：2020-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We hypothesized that chronic mitoprotection would decrease renal vascular remodelling and dysfunction in swine metabolic syndrome. What is the main finding and its importance? This study shows that experimental metabolic syndrome exerts renal microvascular and en...

journal_title：Experimental physiology

authors： Eirin A,Hedayat AF,Ferguson CM,Textor SC,Lerman A,Lerman LO

更新日期：2018-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Non-invasive muscle function tests have not been validated for use in the study of muscle performance in high-fat-fed mice. What is the main finding and its importance? This study shows that grip strength, hang wire and four-limb hanging tests are able to discrim...

journal_title：Experimental physiology

authors： Martinez-Huenchullan SF,McLennan SV,Ban LA,Morsch M,Twigg SM,Tam CS

更新日期：2017-07-01 00:00:00

abstract：:Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa. Intestinal reelin and Dab1 mRNA levels were maximal in the early stages of life, reaching adult levels in 1-month-...

journal_title：Experimental physiology

authors： García-Miranda P,Peral MJ,Ilundain AA

更新日期：2010-04-01 00:00:00

abstract：:Neuropeptides and regulatory peptide hormones control many developmental, physiological and behavioural processes in animals, including humans. The nonapeptides oxytocin and arginine vasopressin are produced and released by the pituitary gland and have actions on many organs and tissues. Receptive cells possess partic...

journal_title：Experimental physiology

authors： Gruber CW

更新日期：2014-01-01 00:00:00

abstract：:We measured plasma levels of L-arginine, its analogue NG-monomethyl-L-arginine (L-NMMA), and related amino acids in normal subjects and uraemic patients (n = 31), before and after haemodialysis. Plasma levels of L-arginine were reduced to less than half of normal values in uraemic subjects compared with controls, and ...

journal_title：Experimental physiology

authors： Mendes Ribeiro AC,Roberts NB,Lane C,Yaqoob M,Ellory JC

更新日期：1996-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Exertional heat stroke is accompanied by a marked inflammatory response. In this study, we explored the time course of acute phase proteins during recovery from severe heat stress in mice and the potential role of skeletal muscles as their source. What is the mai...

journal_title：Experimental physiology

authors： Iwaniec J,Robinson GP,Garcia CK,Murray KO,de Carvalho L,Clanton TL,Laitano O

更新日期：2021-01-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is likely to be mediated, at least in part, by an elevation of ongoing sympathetic nerve activity (SNA). However, the contribution of SNA relative to non-neural mechanisms in mediating Ang II-induced hypertension is an area of i...

journal_title：Experimental physiology

authors： Toney GM,Pedrino GR,Fink GD,Osborn JW

更新日期：2010-05-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? Excitation-contraction coupling in fish hearts is maintained over a range of temperatures that would be cardioplegic to most mammals. Here, we review what is known about the fish cardiac ryanodine receptor, and consider how it may be regulated in a different manner from th...

journal_title：Experimental physiology

authors： Shiels HA,Sitsapesan R

更新日期：2015-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central goal of this study was to elucidate the role of magnesium in the regulation of pulmonary vascular reactivity in relationship to hypoxic pulmonary hypertension. What is the main finding and its importance? We found that magnesium is essential for norma...

journal_title：Experimental physiology

authors： Mu YP,Huang QH,Zhu JL,Zheng SY,Yan FR,Zhuang XL,Sham JSK,Lin MJ

更新日期：2018-04-01 00:00:00

abstract：:Aldosterone influences the kidney's regulation of blood pressure (BP), but aldosterone can contribute to the pathogenesis of hypertension. Blood pressure is reduced with aerobic exercise training (AEX), but the extent to which plasma aldosterone (PA) levels change is unclear. The purpose of this study was to determine...

journal_title：Experimental physiology

authors： Jones JM,Dowling TC,Park JJ,Phares DA,Park JY,Obisesan TO,Brown MD

更新日期：2007-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Oestradiol (E2 ) plays an important role in regulating skeletal muscle strength in females. To what extent does E2 deficiency affect recovery of strength and satellite cell number when muscle is challenged by multiple injuries? What is the main finding and its im...

journal_title：Experimental physiology

authors： Larson AA,Baumann CW,Kyba M,Lowe DA

更新日期：2020-10-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does treatment of obstructive sleep apnoea (OSA) with nocturnal oxygen or continuous positive airway pressure (CPAP) improve hypoxic vascular responses, which are reportedly impaired in OSA? What is the main finding and its importance? Cerebrovascular and cardiov...

journal_title：Experimental physiology

authors： Beaudin AE,Hanly PJ,Raneri JK,Sajobi TT,Anderson TJ,Poulin MJ

更新日期：2019-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does blockade of the IL-6 receptor by tocilizumab inhibit immune cell mobilization to the blood stream in humans during an acute bout of exercise? What is the main finding and its importance? Blockade of IL-6 receptor signalling by tocilizumab attenuates mobiliza...

journal_title：Experimental physiology

authors： Bay ML,Heywood S,Wedell-Neergaard AS,Schauer T,Lehrskov LL,Christensen RH,Legård GE,Jensen PØ,Krogh-Madsen R,Ellingsgaard H

更新日期：2020-10-02 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? What is the main fin...

journal_title：Experimental physiology

authors： Luks AM,Levett D,Martin DS,Goss CH,Mitchell K,Fernandez BO,Feelisch M,Grocott MP,Swenson ER,Caudwell Xtreme Everest Investigators.

更新日期：2017-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do individuals with a patent foramen ovale (PFO+ ) have a larger alveolar-to-arterial difference in P O 2 ...

journal_title：Experimental physiology

authors： Duke JW,Beasley KM,Speros JP,Elliott JE,Laurie SS,Goodman RD,Futral E,Hawn JA,Lovering AT

更新日期：2020-09-01 00:00:00

abstract：:The objective of the experiments was to investigate the cellular basis of the inotropic effect on myocardium of several opioids which have been implicated in producing cardiotoxic effects in human poisoning. Opioids exerted negative inotropic effects, with half-maximal concentrations between 10 microM (dextropropoxyph...

journal_title：Experimental physiology

authors： Wu C,Fry CH,Henry J

更新日期：1997-03-01 00:00:00

abstract：:Brain blood vessels contain muscarinic receptors that are important for cerebral blood flow (CBF) regulation, but whether a cholinergic receptor mechanism is involved in the exercise-induced increase in cerebral perfusion or affects cerebral metabolism remains unknown. We evaluated CBF and cerebral metabolism (from ar...

journal_title：Experimental physiology

authors： Seifert T,Fisher JP,Young CN,Hartwich D,Ogoh S,Raven PB,Fadel PJ,Secher NH

更新日期：2010-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We sought to understand the day-to-day variability of human indirect calorimetry during rest and exercise. Previous work has been unable to separate human day-to-day variability from measurement error and within-trial human variability. We developed models accoun...

journal_title：Experimental physiology

authors： Tenan MS,Bohannon AW,Macfarlane DJ,Crouter SE

更新日期：2018-12-01 00:00:00

abstract：:The effects on vasopressin and cortisol secretion of centrally and peripherally administered cholecystokinin octapeptide (CCK) were investigated in conscious prepubertal pigs. Injection of 1.3 micrograms CCK into the lateral cerebral ventricle resulted in a sustained increase in plasma vasopressin after a latency of 5...

journal_title：Experimental physiology

authors： Parrott RF,Ebenezer IS,Baldwin BA,Forsling ML

更新日期：1991-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the role of miR-143-3p during human dental pulp stem cell (hDPSC) differentiation. What is the main finding and its importance? miR-143-3p negatively regulates receptor activator of nuclear factor-κB (RANK). RANK ligand (RANKL) binds to RANK and stimulate...

journal_title：Experimental physiology

authors： Yang C,Jia R,Zuo Q,Zheng Y,Wu Q,Luo B,Lin P,Yin L

更新日期：2020-05-01 00:00:00

abstract：:The contractile regulation of neonatal smooth muscle was studied in rat neonatal portal vein. Strips of beta-escin-permeabilized portal vein from 3- to 5-day-old rats and 5- to 6-week-old rats were mounted on a 'bubble chamber' in calcium solutions buffered with 10 mM EGTA. Although the overall tension development was...

journal_title：Experimental physiology

authors： Bruce L,Nixon GF

更新日期：1997-11-01 00:00:00

abstract：:What is the central question of this study? Neurocognitive functions can be enhanced by acute aerobic exercise, which could be associated with changes in serum brain-derived neurotrophic factor (BDNF) concentrations. We aimed to explore acute exercise-induced changes in BDNF concentrations, neuropsychological and neur...

journal_title：Experimental physiology

authors： Tsai CL,Pan CY,Chen FC,Wang CH,Chou FY

更新日期：2016-07-01 00:00:00