The role of exercise on long-term effects of alloxan administered in neonatal rats.

abstract：:Disrupting circadian rhythms in rodents perturbs glucose metabolism and increases adiposity. To determine whether these effects occur in a large diurnal animal, we assessed the impact of circadian rhythm disruption upon metabolic function in sheep. Adult ewes (n = 7) underwent 3 weeks of a control 12 h light-12 h dark...

journal_title：Experimental physiology

authors： Varcoe TJ,Gatford KL,Voultsios A,Salkeld MD,Boden MJ,Rattanatray L,Kennaway DJ

更新日期：2014-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Dexmedetomidine has a capacity for sedation, anti-anxiety and analgesia with minimal suppression of respiratory function; what is its role in neuropathic pain and what is the involvement of miRNAs? What is the main finding and its importance? Dexmedetomidine atte...

journal_title：Experimental physiology

authors： Zhang W,Yu T,Cui X,Yu H,Li X

更新日期：2020-09-01 00:00:00

abstract：:The present study examined whether an increase in leg blood flow and oxygen delivery at the onset of intense exercise would speed the rate of rise in leg oxygen uptake. Nine healthy men (25 ± 1 years old, mean ± SEM) performed one-leg knee-extensor exercise (62 ± 3 W, 86 ± 3% of incremental test peak power) for 4 min ...

journal_title：Experimental physiology

authors： Nyberg M,Christensen PM,Mortensen SP,Hellsten Y,Bangsbo J

更新日期：2014-10-01 00:00:00

abstract：:5-[5-(2-Nitrophenyl) furfuryliodine]-1,3-diphenyl-2-thiobarbituric acid (UCF-101) is a protease inhibitor which was reported to protect against ischaemic heart damage and apoptosis. This study evaluated the impact of UCF-101 on steptozotocin (STZ)-induced diabetic cardiomyocyte dysfunction. Adult FVB mice were made di...

journal_title：Experimental physiology

authors： Li Q,Hueckstaedt LK,Ren J

更新日期：2009-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does the combination of methazolamide and theophylline reduce symptoms of acute mountain sickness (AMS) and improve aerobic performance in acute hypobaric hypoxia? What is the main finding and its importance? The oral combination of methazolamide (100 BID) and th...

journal_title：Experimental physiology

authors： Subudhi AW,Evero O,Reitinger J,Davis C,Gronewold J,Nichols AJ,Van-Houten SJ,Roach RC

更新日期：2021-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance? ENaC protein has an unexpected localization in the peripheral region of the apical membrane of bronchial ...

journal_title：Experimental physiology

authors： Musante I,Scudieri P,Venturini A,Guidone D,Caci E,Castellani S,Conese M,Galietta LJV

更新日期：2019-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is there sexual dimorphism in the occurrence of hepatic endoplasmic reticulum stress? What is the main finding and its importance? The transition from prepubertal to the adult age is associated with an increase in the unfolded protein response markers in the live...

journal_title：Experimental physiology

authors： Rossetti CL,de Oliveira Costa HM,Barthem CS,da Silva MH,de Carvalho DP,da-Silva WS

更新日期：2019-05-01 00:00:00

abstract：:Altered systemic haemodynamics following exercise can compromise cerebral perfusion and result in syncope. As the Wingate anaerobic test often induces presyncope, we hypothesized that a modified Wingate test could form the basis of a novel model for the study of postexercise syncope and a test bed for potential counte...

journal_title：Experimental physiology

authors： Lacewell AN,Buck TM,Romero SA,Halliwill JR

更新日期：2014-01-01 00:00:00

abstract：:Fluid and electrolyte movements across the ruminal epithelium of sheep were studied using the temporarily isolated rumen technique. The sheep were all subjected to the following treatments: (1) fed sheep (fed twice daily), after rumen emptying, received rumen contents from a fed sheep; (2) food-deprived sheep (two mea...

journal_title：Experimental physiology

authors： Holtenius K,Dahlborn K

更新日期：1990-01-01 00:00:00

abstract：:Aortic bodies are arterial chemoreceptors presumed to monitor blood O2 content by unknown mechanisms, in contrast to their well-studied carotid body counterparts, which monitor PO2 and /pH. We recently showed that rat aortic body chemoreceptors (type I cells), located at the left vagus-recurrent laryngeal nerve bifurc...

journal_title：Experimental physiology

authors： Piskuric NA,Zhang M,Vollmer C,Nurse CA

更新日期：2014-01-01 00:00:00

abstract：:The objective of this study was to examine the potential of stearic acid to induce cardiomyocyte cell death and the hypothesis that the amount of cellular lipid is a determinant of cell death. In cardiomyocytes from embryonic chick heart, stearic acid (SA) produced a significant (P < 0.001) concentration-dependent inc...

journal_title：Experimental physiology

authors： Rabkin SW,Lodhia P

更新日期：2009-08-01 00:00:00

abstract：:The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...

journal_title：Experimental physiology

authors： Van Obbergh L,Leonard V,Chen H,Xu D,Blaise G

更新日期：1995-07-01 00:00:00

abstract：:Our aim was to analyse endothelial hypoxic preconditioning after hypoxia-reperfusion (HR). Endothelial functionality was analysed through the vasorelaxation responses to acetylcholine (Ach) and the level of serine1177 phosphorylated endothelial nitric oxide synthase (eNOS) (ser1177-eNOS) measured by Western blot in in...

journal_title：Experimental physiology

authors： Carrasco-Martín C,Alonso-Orgaz S,De la Pinta JC,Marques M,Macaya C,Barrientos A,González MM,García-Méndez A,Mateos-Cáceres PJ,Porres JC,Rico LA,López-Farré AJ

更新日期：2005-07-01 00:00:00

abstract：:Joint movement was recently shown to stimulate the secretion of the lubricant hyaluronan (HA); also, exercise therapy and intra-articular hyaluronan injections are used to treat moderate osteoarthritis. The present study quantifies the stimulus-response curves for HA secretion in vivo and reports a role of transcripti...

journal_title：Experimental physiology

authors： Wann AK,Ingram KR,Coleman PJ,McHale N,Levick JR

更新日期：2009-03-01 00:00:00

abstract：:Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting many systems throughout the body and appears to alter offspring phenotypes. The aim of this study was to examine the influence of parental exercise training, or 'exerc...

journal_title：Experimental physiology

authors： Guth LM,Ludlow AT,Witkowski S,Marshall MR,Lima LC,Venezia AC,Xiao T,Ting Lee ML,Spangenburg EE,Roth SM

更新日期：2013-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the cellular and molecular determinants of increased risk for cardiovascular disease from prolonged sitting? What is the main finding and its importance? Prolonged sitting, independent of calf raise interruption strategies, decreases microparticle counts...

journal_title：Experimental physiology

authors： Evans WS,Hanson ED,Shill DD,Landers-Ramos RQ,Stoner L,Willey Q,Credeur DP,Prior SJ

更新日期：2020-08-01 00:00:00

abstract：:Oxidants have been suggested to enhance contractile function in unfatigued muscle. In this study we aimed to determine the effect of oxidants on "chemically skinned" diaphragm muscle fibre bundles. The sarcoplasmic reticulum and contractile proteins were exposed to superoxide anions (O2-) and hydrogen peroxide (H2O2) ...

journal_title：Experimental physiology

authors： Darnley GM,Duke AM,Steele DS,MacFarlane NG

更新日期：2001-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...

journal_title：Experimental physiology

authors： Yang K,Wang J,Lu W

更新日期：2017-09-01 00:00:00

abstract：:Hypoglossal nerve activity (HNA) controls the position and movements of the tongue. In persons with compromised upper airway anatomy, sleep-related hypotonia of the tongue and other pharyngeal muscles causes increased upper airway resistance, or total upper airway obstructions, thus disrupting both sleep and breathing...

journal_title：Experimental physiology

authors： Brandes IF,Stettner GM,Mörschel M,Kubin L,Dutschmann M

更新日期：2011-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Calcium is an important second messenger in eccrine sweating; however, whether modulation of extracellular Ca(2+) and Ca(2+) entry has the capacity to modulate sweat rate in non-glabrous human skin has not been explored. What is the main finding and its importanc...

journal_title：Experimental physiology

authors： Metzler-Wilson K,Sammons DL,Ossim MA,Metzger NR,Jurovcik AJ,Krause BA,Wilson TE

更新日期：2014-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? In this review, we examine the evidence for control mechanisms underlying exercise hyperpnoea, giving attention to the feedback from thin-fibre skeletal muscle afferents, and highlight the frequently conflicting findings and difficulties encountered by researchers using a ...

journal_title：Experimental physiology

authors： Bruce RM,Jolley C,White MJ

更新日期：2019-11-01 00:00:00

abstract：:Exposure to whole-body vibration is implicated as one of the occupational risk factors for lower back disorders; however, its influence on the lumbar muscle physiology is still poorly understood. The objective of this study was to investigate the effects of backrest support and hand grip contractions on lumbar muscle ...

journal_title：Experimental physiology

authors： Maikala RV,Bhambhani YN

更新日期：2006-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We modelled the alveolar pathway during breath holding on the hypothesis that it follows a hypoventilation loop on the O2 -CO2 diagram. What is the main finding and its importance? Validation of the model was possible within the range of alveolar gas compositions...

journal_title：Experimental physiology

authors： Taboni A,Fagoni N,Fontolliet T,Grasso GS,Moia C,Vinetti G,Ferretti G

更新日期：2020-09-29 00:00:00

abstract：:Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also redu...

journal_title：Experimental physiology

authors： Rajnicek AM,Gow NA,McCaig CD

更新日期：1992-01-01 00:00:00

abstract：:Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units i...

journal_title：Experimental physiology

authors： Wallis WR,Wu C,Sheridan DJ,Fry CH

更新日期：1997-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of the study? What are the effects of age and fitness on the vascular response to acute inflammation in younger and older adults? What is the main finding and its importance? In older adults, cardiorespiratory fitness level has a differential impact on endothelial function afte...

journal_title：Experimental physiology

authors： Schroeder EC,Lane-Cordova AD,Ranadive SM,Baynard T,Fernhall B

更新日期：2018-06-01 00:00:00

abstract：:Phosphoethanolamine and taurine have been identified in uterine extracts from rat and, for the first time, human tissue. The concentration of phosphoethanolamine [PEtn] determined by HPLC and 31P NMR spectroscopy, increased markedly (40%) within the first 6-12 h following parturition in rats, suggesting a role in invo...

journal_title：Experimental physiology

authors： Phoenix J,Wray S

更新日期：1994-07-01 00:00:00

abstract：:The contribution of almitrine bismesylate to the occurrence and pattern of augmented breaths was studied in fifteen spontaneously breathing, anaesthetized cats. Breathing was via a tracheostomy, while the laryngeal resistance to airflow was measured with the larynx isolated in situ. Almitrine bismesylate at a dose of ...

journal_title：Experimental physiology

authors： Szereda-Przestaszewska M,Jakus J,Stránsky A,Baráni H

更新日期：1992-01-01 00:00:00

abstract：:The role of testosterone (T) in the regulation of cardiovascular function in females is not well understood. Our goal was to examine the effect of T on cardiomyocyte biology by measuring sarcomere shortening/relaxation and intracellular calcium cycling in adult female Sprague-Dawley rats. The rats were divided into th...

journal_title：Experimental physiology

authors： Beesley RD,Palmer BM,Casson PR,Toth MJ

更新日期：2013-01-01 00:00:00

abstract：:In pentobarbitione-anaesthetized rats the parasympathetic auriculotemporal nerve of the parotid gland was continuously stimulated at supramaximal voltage and at maximal frequency (40 Hz) for salivary secretion. The animals were pretreated with phentolamine and propranolol (2 mg kg-1 i.p. of each) and, in some groups, ...

journal_title：Experimental physiology

authors： Ekström J,Asztély A,Tobin G

更新日期：1996-11-01 00:00:00