Effects of reactive oxygen species on aspects of excitation-contraction coupling in chemically skinned rabbit diaphragm muscle fibres.

abstract：:Simultaneous portal blood absorption and intestinal mucosal catabolism of labelled fatty acids were investigated. Anaesthetized adult Wistar rats were infused intraduodenally either with 90 mumol of capric (C10:0), oleic (C18:1), linoleic (C18:2) or arachidonic (C20:4) 1-14C acids or with 30 mumol of each labelled fat...

journal_title：Experimental physiology

authors： Bernard A,Carlier H

更新日期：1991-05-01 00:00:00

abstract：:Non-invasive autonomic evaluation has used fast Fourier transform (FFT) to assign a range of low (LF) and high frequencies (HF) as markers of sympathetic and parasympathetic influences, respectively. However, FFT cannot be applied to brief transient phenomena, such as those observed on performing autonomic tests where...

journal_title：Experimental physiology

authors： Ducla-Soares JL,Santos-Bento M,Laranjo S,Andrade A,Ducla-Soares E,Boto JP,Silva-Carvalho L,Rocha I

更新日期：2007-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What factors influence the onset and magnitude of activation of the neck inspiratory muscles during inspiration? What is the main finding and its importance? Recruitment of the sternocleidomastoid and scalene muscles during inspiration, measured by means of surfa...

journal_title：Experimental physiology

authors： Washino S,Mankyu H,Kanehisa H,Mayfield DL,Cresswell AG,Yoshitake Y

更新日期：2019-04-01 00:00:00

abstract：:Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...

journal_title：Experimental physiology

authors： Kraniou GN,Cameron-Smith D,Hargreaves M

更新日期：2004-09-01 00:00:00

abstract：:In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...

journal_title：Experimental physiology

authors： Hill-Venning C,Cottrell GA

更新日期：1992-11-01 00:00:00

abstract：:This work was undertaken to study the effect of pectin feeding on the expression level, cellular localization and functional activity of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of rats. The results indicated that MCT1 protein level was significantly increased along the entire length of the g...

journal_title：Experimental physiology

authors： Kirat D,Kondo K,Shimada R,Kato S

更新日期：2009-04-01 00:00:00

abstract：:The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...

journal_title：Experimental physiology

authors： Van Obbergh L,Leonard V,Chen H,Xu D,Blaise G

更新日期：1995-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? A transcranial magnetic stimulation (TMS)-induced twitch applied on isolated single breaths over the motor cortex somatotopic representation of the tongue briefly recruits submental muscles and improves airflow dynamics of flow-limited respiratory cycles without ...

journal_title：Experimental physiology

authors： Melo-Silva CA,Gakwaya S,Rousseau E,Sériès F

更新日期：2013-09-01 00:00:00

abstract：:After 2 months of streptozotocin-induced diabetes in rats, the membrane potential of the diaphragm muscle when measured in vitro at 30 degrees C was unchanged but the tetanic tension, the half-relaxation time of the isometric twitch and the fatigue resistance were each reduced. Treatment of the diabetic rats with the ...

journal_title：Experimental physiology

authors： McGuire M,MacDermott M

更新日期：1998-07-01 00:00:00

abstract：:The cardiovascular response to isometric exercise is governed by both central and peripheral mechanisms. Both metabolic and mechanical stresses on the exercising skeletal muscle produce cardiovascular change, yet it is often overlooked that the afferent signal arising from the muscle can be modified by factors other t...

journal_title：Experimental physiology

authors： Fisher JP,White MJ

更新日期：2004-11-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：:It has been shown previously that the amplitudes of the harmonic components of the pulse spectrum vary in specific patterns when the arteries leading to different organs are ligated, with the variations in the harmonics being linearly additive. Since ligation can be regarded as a vast increase in organ resistance, the...

journal_title：Experimental physiology

authors： Hsu TL,Chao PT,Hsiu H,Wang WK,Li SP,Wang YY

更新日期：2006-01-01 00:00:00

abstract：:It is unknown whether changes in corticomotor excitability follow prolonged exercise in healthy humans. Furthermore, the role of supraspinal fatigue in decrements of force production and voluntary activation following prolonged exercise has not been established. This study investigated peripheral and central fatigue a...

journal_title：Experimental physiology

authors： Ross EZ,Middleton N,Shave R,George K,Nowicky A

更新日期：2007-03-01 00:00:00

abstract：:Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

journal_title：Experimental physiology

authors： Maughan RJ,Leiper JB,McGaw BA

更新日期：1990-05-01 00:00:00

abstract：:The application of the four main techniques available for examining the properties of alpha-adrenoceptors, gene coding, radioligand, biochemical and functional methods, has reinforced the earlier subclassification (alpha 1- and alpha 2-subtypes). These different techniques have not yet yielded subclassifications which...

journal_title：Experimental physiology

authors： Wilson VG,Brown CM,McGrath JC

更新日期：1991-05-01 00:00:00

abstract：:Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle-associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) ...

journal_title：Experimental physiology

authors： Porta C,James PS,Phillips AD,Savidge TC,Smith MW,Cremaschi D

更新日期：1992-11-01 00:00:00

abstract：:Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compar...

journal_title：Experimental physiology

authors： Smith MW,Phillips AD

更新日期：1990-07-01 00:00:00

abstract：:Sympathetic baroreflex sensitivity is increased during selective activation of the skeletal muscle metaboreflex with postexercise ischaemia (PEI) in young adults. However, to date, there are no data demonstrating this neural interaction between the arterial baroreflex and the muscle metaboreflex in healthy older adult...

journal_title：Experimental physiology

authors： Greaney JL,Schwartz CE,Edwards DG,Fadel PJ,Farquhar WB

更新日期：2013-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a family history of hypertension. What is the main f...

journal_title：Experimental physiology

authors： Matthews EL,Greaney JL,Wenner MM

更新日期：2017-09-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? Patients with advanced heart failure who are implanted with left ventricular assist devices (LVADs) present an opportunity to understand the human circulation under extreme conditions. What advances does it highlight? LVAD patients have a unique circulation that is charact...

journal_title：Experimental physiology

authors： Stöhr EJ,Cornwell WK 3rd,Kanwar M,Cockcroft JR,McDonnell BJ

更新日期：2020-05-01 00:00:00

abstract：:The present work reports the effect of pHo on pHi and Na(+)-H+ exchanger activity. Intracellular pH tended to follow pHo, but the proton distribution across the cell membrane is not at electrochemical equilibrium. Removal of external Na+ acidified the cells by both reversing the direction of the Na(+)-H+ exchanger and...

journal_title：Experimental physiology

authors： Peral MJ,Calonge ML,Ilundáin AA

更新日期：1995-11-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...

journal_title：Experimental physiology

authors： Silver J,Wadley G,Lamon S

更新日期：2018-08-01 00:00:00

abstract：:Mechanical properties of the vascular smooth muscle from normal and dystrophin-deficient (mdx) mice were examined. Changes in resting and developed tensions in response to stretch were recorded in isolated portal vein. The vascular segments were elongated in 5 % increments of the 'in situ' length (Lr) up to 1.30Lr. Th...

journal_title：Experimental physiology

authors： Mancinelli R,Tonali P,Romani R,Tringali A,Vargiu R,AZZENA GB

更新日期：1999-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We present a new non-invasive medical technology, the inspired sine-wave technique, which involves inhalation of sinusoidally fluctuating concentrations of a tracer gas. The technique requires only passive patient cooperation and can monitor different cardiorespi...

journal_title：Experimental physiology

authors： Bruce RM,Phan PA,Pacpaco E,Rahman NM,Farmery AD

更新日期：2018-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months h...

journal_title：Experimental physiology

authors： Oghbaei H,Alipour MR,Hamidian G,Ahmadi M,Ghorbanzadeh V,Keyhanmanesh R

更新日期：2018-12-01 00:00:00

abstract：:Rats were submitted to 14 days of hindlimb suspension in order to examine the contractile and elastic properties of the soleus muscles under disuse conditions. The calcium/strontium activation properties, the maximal shortening velocity (V0), as well as the time behaviour of force transients following quick releases a...

journal_title：Experimental physiology

authors： Toursel T,Stevens L,Mounier Y

更新日期：1999-01-01 00:00:00

abstract：:The pattern of propagation of slow waves in the small intestine is not clear. Specifically, it is not known whether propagation is determined by a single dominant ICC-MP (Interstitial cells of Cajal located in the Myenteric Plexus) pacemaker unit or whether there are multiple active pacemakers. To determine this patte...

journal_title：Experimental physiology

authors： Lammers WJ,Stephen B

更新日期：2008-03-01 00:00:00

abstract：:Pairs of Ia and II afferent fibres supplying primary and secondary endings lying in the same tenuissimus spindles were prepared in barbiturate anaesthetized cats in order to compare the variability in the rhythm of discharge of the two endings during responses elicited by the contraction of different intrafusal muscle...

journal_title：Experimental physiology

authors： Celichowski J,Emonet-Dénand F,Gladden M,Laporte Y,Petit J

更新日期：1994-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Type 2 diabetes is associated with a higher rate of ventricular arrhythmias compared with the non-diabetic population, but the associated myocardial gene expression changes are unknown; furthermore, it is also unknown whether any changes are attributable to chron...

journal_title：Experimental physiology

authors： Ashrafi R,Modi P,Oo AY,Pullan DM,Jian K,Zhang H,Gerges JY,Hart G,Boyett MR,Davis GK,Wilding JPH

更新日期：2017-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the ultrastructural changes of the caecal mucosa and the status of epithelial cellular apoptosis and oxidative reactions in lactating goats after prolonged feeding with a high-concentrate diet? What is the main finding and its importance? High-concentrat...

journal_title：Experimental physiology

authors： Tao S,Tian J,Cong R,Sun L,Duanmu Y,Dong H,Ni Y,Zhao R

更新日期：2015-03-01 00:00:00