Primary and secondary afferent discharges from the same spindle during chain fibre contraction in cat tenuissimus muscle.

abstract：NEW FINDINGS:What is the central question of this study? What is the role of lncRNA PRRT3-AS1 in the regulation of peroxisome proliferator-activated receptor γ (PPARγ) gene-mediated mechanistic target of rapamycin (mTOR) signalling pathway in proliferation, apoptosis and autophagy of prostate cancer cells? What is the ...

journal_title：Experimental physiology

authors： Fan L,Li H,Wang W

更新日期：2020-05-01 00:00:00

abstract：:Latex beads coated with secretory immunoglobulin (IgA) instilled into mouse intestinal loops are taken up by M cells present in Peyer's patch follicle-associated epithelial tissue. Bead adsorption and uptake is greater at the edge compared with the apex of follicle domes. Coating beads with bovine serum albumin (BSA) ...

journal_title：Experimental physiology

authors： Porta C,James PS,Phillips AD,Savidge TC,Smith MW,Cremaschi D

更新日期：1992-11-01 00:00:00

abstract：:The hypothalamus regulates the key hormonal signalling events essential for reproduction and fertility in mammals. The gonadotrophin-releasing hormone (GnRH) neurons are the principal neurons of the complex neuronal network that co-ordinates multiple internal homeostatic and external factors necessary for fertility. K...

journal_title：Experimental physiology

authors： Yeo SH

更新日期：2013-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does baroreceptor unloading during passive hyperthermia contribute to increases in ventilation and decreases in end-tidal carbon dioxide during that exposure? What is the main finding and its importance? Hyperthermic hyperventilation is not mitigated by expanding...

journal_title：Experimental physiology

authors： Lucas RA,Pearson J,Schlader ZJ,Crandall CG

更新日期：2015-11-01 00:00:00

abstract：:The effects on vasopressin and cortisol secretion of centrally and peripherally administered cholecystokinin octapeptide (CCK) were investigated in conscious prepubertal pigs. Injection of 1.3 micrograms CCK into the lateral cerebral ventricle resulted in a sustained increase in plasma vasopressin after a latency of 5...

journal_title：Experimental physiology

authors： Parrott RF,Ebenezer IS,Baldwin BA,Forsling ML

更新日期：1991-07-01 00:00:00

abstract：:A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...

journal_title：Experimental physiology

authors： Lafortuna CL,Albertini M,Ferrucci F,Zucca E,Braghieri M,Clement MG,Saibene F

更新日期：1999-07-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? Excitation-contraction coupling in fish hearts is maintained over a range of temperatures that would be cardioplegic to most mammals. Here, we review what is known about the fish cardiac ryanodine receptor, and consider how it may be regulated in a different manner from th...

journal_title：Experimental physiology

authors： Shiels HA,Sitsapesan R

更新日期：2015-12-01 00:00:00

abstract：:Adenosine 5'-triphosphate (ATP) is a cotransmitter with classical transmitters in most nerves in the peripheral and central nervous systems, although the proportions vary between tissues and species and in different developmental and pathophysiological circumstances. There was early evidence that ATP was released toge...

journal_title：Experimental physiology

authors： Burnstock G

更新日期：2009-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Although peripheral blood haematopoietic stem and progenitor cells are potentially important in regeneration after acute myocardial infarction, their self-renewal ability in the post-acute phase has not yet been addressed. What is the main finding and its importa...

journal_title：Experimental physiology

authors： Kröpfl JM,Spengler CM,Frobert A,Ajalbert G,Giraud MN

更新日期：2018-01-01 00:00:00

abstract：:What is the central question of this study? Myocardial ischaemia-reperfusion (I/R) injury causes interference in the systemic circulation and damages not only the heart but also several vital organs, including the brain. Recently, a novel peptide called humanin has been shown to exert potent neuroprotective effects. H...

journal_title：Experimental physiology

authors： Kumfu S,Charununtakorn ST,Jaiwongkam T,Chattipakorn N,Chattipakorn SC

更新日期：2016-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the nature of slow wave-driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaux are composed of discrete waves of increased interval, each wave associated with a contraction dislocatio...

journal_title：Experimental physiology

authors： Parsons SP,Huizinga JD

更新日期：2018-08-01 00:00:00

abstract：:Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing response by supplementation of growth factors or transplantation of vascular progenitor cells. These supplements are intended to foster the formation of arterial coll...

journal_title：Experimental physiology

authors： Madeddu P

更新日期：2005-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does the combination of methazolamide and theophylline reduce symptoms of acute mountain sickness (AMS) and improve aerobic performance in acute hypobaric hypoxia? What is the main finding and its importance? The oral combination of methazolamide (100 BID) and th...

journal_title：Experimental physiology

authors： Subudhi AW,Evero O,Reitinger J,Davis C,Gronewold J,Nichols AJ,Van-Houten SJ,Roach RC

更新日期：2021-01-01 00:00:00

abstract：:The aims of this study were: (1) to determine the within-subject, between-day variability in end-tidal P(CO2) (P(ET,CO2)); (2) to determine whether the within-subject, between-day variability in P(ET,CO2) was caused by variations in metabolic acid-base status; and (3) to determine whether between-subject variations in...

journal_title：Experimental physiology

authors： Crosby A,Robbins PA

更新日期：2003-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical studies suggest that obesity 'protects' against osteoporosis. However, these studies used only bone densitometry and assessed only one bone site, which is insufficient to enable conclusions to be drawn about the response of the whole skeleton. Furthermor...

journal_title：Experimental physiology

authors： Lacerda DR,Serakides R,de Melo Ocarino N,Ferreira AV,Moraes MM,Boeloni JN,Silva JF,de Oliveira MC,de Barcellos LA,Rodrigues LO,Soares DD

更新日期：2015-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does blockade of the IL-6 receptor by tocilizumab inhibit immune cell mobilization to the blood stream in humans during an acute bout of exercise? What is the main finding and its importance? Blockade of IL-6 receptor signalling by tocilizumab attenuates mobiliza...

journal_title：Experimental physiology

authors： Bay ML,Heywood S,Wedell-Neergaard AS,Schauer T,Lehrskov LL,Christensen RH,Legård GE,Jensen PØ,Krogh-Madsen R,Ellingsgaard H

更新日期：2020-10-02 00:00:00

abstract：:It has been shown previously that the amplitudes of the harmonic components of the pulse spectrum vary in specific patterns when the arteries leading to different organs are ligated, with the variations in the harmonics being linearly additive. Since ligation can be regarded as a vast increase in organ resistance, the...

journal_title：Experimental physiology

authors： Hsu TL,Chao PT,Hsiu H,Wang WK,Li SP,Wang YY

更新日期：2006-01-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This brief review discusses potential sex differences in arterial function across the age span, with special emphasis on the effects of oestrogen and testosterone on the vascular endothelium. What advances does it highlight? We discuss the relationship between the impacts ...

journal_title：Experimental physiology

authors： Green DJ,Hopkins ND,Jones H,Thijssen DH,Eijsvogels TM,Yeap BB

更新日期：2016-02-01 00:00:00

abstract：:Our aim was to analyse endothelial hypoxic preconditioning after hypoxia-reperfusion (HR). Endothelial functionality was analysed through the vasorelaxation responses to acetylcholine (Ach) and the level of serine1177 phosphorylated endothelial nitric oxide synthase (eNOS) (ser1177-eNOS) measured by Western blot in in...

journal_title：Experimental physiology

authors： Carrasco-Martín C,Alonso-Orgaz S,De la Pinta JC,Marques M,Macaya C,Barrientos A,González MM,García-Méndez A,Mateos-Cáceres PJ,Porres JC,Rico LA,López-Farré AJ

更新日期：2005-07-01 00:00:00

abstract：:The precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is ...

journal_title：Experimental physiology

authors： Burrell LM,Risvanis J,Johnston CI,Naitoh M,Balding LC

更新日期：2000-03-01 00:00:00

abstract：:We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

journal_title：Experimental physiology

authors： Cairns SP,Robinson DM,Loiselle DS

更新日期：2008-07-01 00:00:00

abstract：:Measurements of intracellular calcium (Ca2+i) and sodium (Na+i) have been made in single smooth muscle cells in confluent cultures of the A7r5 cell line using the Ca(2+)- and Na(+)-sensitive dyes Fura-2 and sodium-binding benzofuran isophthalate (SBFI). Reversal of the Na+ gradient in control cells results in a small ...

journal_title：Experimental physiology

authors： Gillespie JI,Otun H,Greenwell JR,Dunlop W

更新日期：1992-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? To what extent focal abdominal aortic aneurysmal (AAA) disease is associated with systemic remodelling of the vascular tree remains unknown. The present study examined whether anatomical differences exist between distances of the intervisceral artery origins and ...

journal_title：Experimental physiology

authors： Bailey DM,Evans TG,Thomas KG,White RD,Twine CP,Lewis MH,Williams IM

更新日期：2016-08-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review concerns the negative impact of pulmonary hypertension (PH) on the pulmonary haemodynamic and gas exchange responses to exercise, considering the mechanisms by which PH plays a role in exercise intolerance in heart failure (HF) patients. What advances does it h...

journal_title：Experimental physiology

authors： Taylor BJ,Shapiro BP,Johnson BD

更新日期：2020-02-24 00:00:00

abstract：:The glucagon response to insulin-induced hypoglycaemia was tested in rats that had been pinealectomised (Px), pinealectomised and fitted with melatonin implants (Px + MLT), or sham-operated (SO). The glucagon response to hypoglycaemia observed in SO rats (216 +/- 27 pg x ml(-1) at baseline versus 397 +/- 35 pg x ml(-1...

journal_title：Experimental physiology

authors： Kosa E,Maurel D,Siaud P

更新日期：2001-09-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review provides a comprehensive overview of Nox5 from basic biology to human disease and highlights unique features of this Nox isoform What advances does it highlight? Major advances in Nox5 biology relate to crystallization of the molecule and new insights into the ...

journal_title：Experimental physiology

authors： Touyz RM,Anagnostopoulou A,Rios F,Montezano AC,Camargo LL

更新日期：2019-05-01 00:00:00

abstract：:The effects of hypotonic solutions on intracellular Ca2+ were determined on primary cultures of human detrusor smooth muscle cells. In the presence of external Ca2+, changing from a solution containing 290 mosmol l-1 to one containing 240 mosmol l-1 (80% normal tonicity) activated a rise in intracellular Ca2+. If the ...

journal_title：Experimental physiology

authors： Chambers P,Neal DE,Gillespie JI

更新日期：1997-07-01 00:00:00

abstract：:Using the patch-clamp recording technique, we observed that endothelin-1 (ET-1; 0.8-16 nM) enhanced a voltage-activated outward current (Iout) and induced periodic oscillations of inward current in smooth muscle cells isolated from small pulmonary arteries (200-400 microns in diameter). Anion substitution experiments ...

journal_title：Experimental physiology

authors： Salter KJ,Turner JL,Albarwani S,Clapp LH,Kozlowski RZ

更新日期：1995-09-01 00:00:00

abstract：:Contraction-mediated injury is a major contributing factor to the pathophysiology of muscular dystrophy and therefore therapies that can attenuate this type of injury have clinical relevance. Systemic administration of insulin-like growth factor-I (IGF-I) has been shown to improve muscle function in dystrophic mdx mic...

journal_title：Experimental physiology

authors： Gehrig SM,Ryall JG,Schertzer JD,Lynch GS

更新日期：2008-11-01 00:00:00

abstract：:We measured plasma levels of L-arginine, its analogue NG-monomethyl-L-arginine (L-NMMA), and related amino acids in normal subjects and uraemic patients (n = 31), before and after haemodialysis. Plasma levels of L-arginine were reduced to less than half of normal values in uraemic subjects compared with controls, and ...

journal_title：Experimental physiology

authors： Mendes Ribeiro AC,Roberts NB,Lane C,Yaqoob M,Ellory JC

更新日期：1996-05-01 00:00:00