Abstract:
:The precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is synthesized not only in the hypophysial-pituitary axis but also in peripheral tissues including the heart where it acts as a paracrine hormone. Thirdly, vasopressin has vasoconstrictor, mitogenic, hyperplastic and renal fluid retaining properties which, by analogy with angiotensin II, may have deleterious effects when present in chronic excess. Finally, the availability of orally active non-peptide vasopressin receptor antagonists allows vasopressin receptor antagonism to be considered as a therapeutic option in cardiovascular disease.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Burrell LM,Risvanis J,Johnston CI,Naitoh M,Balding LCdoi
10.1111/j.1469-445x.2000.tb00031.xsubject
Has Abstractpub_date
2000-03-01 00:00:00pages
259S-265Seissn
0958-0670issn
1469-445Xjournal_volume
85 Spec Nopub_type
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