Protein kinase C-dependent inhibition of K+ currents in noradrenaline-induced depolarization of smooth muscle of guinea-pig vas deferens.

abstract：NEW FINDINGS:What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inf...

journal_title：Experimental physiology

authors： Koyuncuoğlu T,Arabacı Tamer S,Erzik C,Karagöz A,Akakın D,Yüksel M,Yeğen BÇ

更新日期：2019-12-01 00:00:00

abstract：:It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function. The aims of this study were to compare and contrast three different mouse skeletal muscl...

journal_title：Experimental physiology

authors： Jacobs RA,Díaz V,Meinild AK,Gassmann M,Lundby C

更新日期：2013-04-01 00:00:00

abstract：:In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...

journal_title：Experimental physiology

authors： Hill-Venning C,Cottrell GA

更新日期：1992-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the nature of slow wave-driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaux are composed of discrete waves of increased interval, each wave associated with a contraction dislocatio...

journal_title：Experimental physiology

authors： Parsons SP,Huizinga JD

更新日期：2018-08-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. What advances does it highlight? Physiological studies have recently ...

journal_title：Experimental physiology

authors： Wray S

更新日期：2015-12-01 00:00:00

abstract：:Altering [K+]o might have different effects on action potential duration (APD) in myocytes from different regions. Therefore, the effects of [K+]o on regional differences in action potential characteristics were investigated in sub-endocardial, mid-myocardial and sub-epicardial myocytes isolated from the base of guine...

journal_title：Experimental physiology

authors： Wan X,Bryant SM,Hart G

更新日期：2000-11-01 00:00:00

abstract：:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (...

journal_title：Experimental physiology

authors： Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TL

更新日期：1998-09-01 00:00:00

abstract：:Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting many systems throughout the body and appears to alter offspring phenotypes. The aim of this study was to examine the influence of parental exercise training, or 'exerc...

journal_title：Experimental physiology

authors： Guth LM,Ludlow AT,Witkowski S,Marshall MR,Lima LC,Venezia AC,Xiao T,Ting Lee ML,Spangenburg EE,Roth SM

更新日期：2013-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? What is the main fin...

journal_title：Experimental physiology

authors： Luks AM,Levett D,Martin DS,Goss CH,Mitchell K,Fernandez BO,Feelisch M,Grocott MP,Swenson ER,Caudwell Xtreme Everest Investigators.

更新日期：2017-06-01 00:00:00

abstract：:This study presents a perfused preparation for evaluation of metabolism in pig intercostal muscle in vitro. Preserved vessels and nerves to an intercostal segment including two adjacent ribs allowed for tissue perfusion and electrical stimulation with measurement of contraction force, oxygen consumption and 31P-magnet...

journal_title：Experimental physiology

authors： Pedersen BL,Arendrup H,Secher NH,Quistorff B

更新日期：2006-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the ultrastructural changes of the caecal mucosa and the status of epithelial cellular apoptosis and oxidative reactions in lactating goats after prolonged feeding with a high-concentrate diet? What is the main finding and its importance? High-concentrat...

journal_title：Experimental physiology

authors： Tao S,Tian J,Cong R,Sun L,Duanmu Y,Dong H,Ni Y,Zhao R

更新日期：2015-03-01 00:00:00

abstract：:The inward transport of two purines, adenosine and hypoxanthine, at 37 degrees C by horse erythrocytes was compared. No mediated transport of adenosine was detected in horse erythrocytes, nor was saturable, high-affinity binding of the potent facilitated-diffusion inhibitor nitrobenzylthioinosine demonstrable in horse...

journal_title：Experimental physiology

authors： Jarvis SM,Harris RC

更新日期：1998-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Should we use the high-frequency (HF) component of P-P interval as an index of cardiac parasympathetic nerve activity during moderate exercise? What is the main finding and its importance? The HF component of P-P interval variability remained even at a heart rate...

journal_title：Experimental physiology

authors： Takahashi M,Nakamoto T,Matsukawa K,Ishii K,Watanabe T,Sekikawa K,Hamada H

更新日期：2016-03-01 00:00:00

abstract：:Mammalian cardiomyocytes have limited regenerative capacity, such that cell death can result in a net loss of viable contractile elements and a decrease in cardiac functional reserve, both during normal ageing and after insults to the myocardium leading to heart failure. At least four types of cell death have been des...

journal_title：Experimental physiology

authors： Goldspink DF,Burniston JG,Tan LB

更新日期：2003-05-01 00:00:00

abstract：:Neural activation decreases cerebral deoxyhaemoglobin (HHb(C)) and increases oxyhaemoglobin concentration (O(2)Hb(C)). In contrast, patients who present with restricted cerebral blood flow, such as those suffering from cerebral ischaemia or Alzheimer's disease, and during the course of ageing the converse occurs, in t...

journal_title：Experimental physiology

authors： Miyazawa T,Horiuchi M,Ichikawa D,Sato K,Tanaka N,Bailey DM,Ogoh S

更新日期：2012-02-01 00:00:00

abstract：:Arterial pressure is regulated over long periods of time by neural, hormonal and local control mechanisms, which ultimately determine the total blood volume and how it is distributed between the various vascular compartments of the circulation. A full understanding of the complex interplay of these mechanisms can be g...

journal_title：Experimental physiology

authors： Osborn JW,Averina VA,Fink GD

更新日期：2009-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? At near-term gestation, foramen ovale blood flow accounts for a significant proportion of fetal left ventricular output. Can the foramen ovale increase its volume blood flow when right ventricular afterload is increased by main pulmonary artery occlusion? What is...

journal_title：Experimental physiology

authors： Lantto J,Erkinaro T,Haapsamo M,Huhta H,Voipio HM,Hohimer AR,Davis LE,Acharya G,Räsänen J

更新日期：2019-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We present a new non-invasive medical technology, the inspired sine-wave technique, which involves inhalation of sinusoidally fluctuating concentrations of a tracer gas. The technique requires only passive patient cooperation and can monitor different cardiorespi...

journal_title：Experimental physiology

authors： Bruce RM,Phan PA,Pacpaco E,Rahman NM,Farmery AD

更新日期：2018-05-01 00:00:00

abstract：:In this study we tested the hypothesis that, compared to young adult rats, senescent rats have a reduced ability to respond to muscle unloading. Unloading of the muscles was induced by hindlimb suspension (HS) of young adult and senescent rats for 21 days. Plantaris muscles from young adult rats had significantly high...

journal_title：Experimental physiology

authors： Alway SE,Lowe DA,Chen KD

更新日期：2001-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...

journal_title：Experimental physiology

authors： Sharma A,Kumar V

更新日期：2019-12-01 00:00:00

abstract：:Resting heart rate and heart rate variability of 33 postmenopausal women were compared with those of 50 premenopausal women of comparable activity level, none of whom had used hormone replacement therapy. Heart rate was measured as the mean of at least 600 consecutive R-R intervals obtained from electrocardiograph (EC...

journal_title：Experimental physiology

authors： Brockbank CL,Chatterjee F,Bruce SA,Woledge RC

更新日期：2000-05-01 00:00:00

abstract：:The effects of two different feeding regimes on the 24 h profiles of maternal and fetal plasma cortisol and adrenocorticotrophic hormone (ACTH) concentrations were studied in eight pregnant ewes between 123 and 144 days of gestation. Once daily-fed ewes (n = 4) received 1 kg of lucerne-chaff at 11.00 h, and multi-fed ...

journal_title：Experimental physiology

authors： Simonetta G,Walker DW,McMillen IC

更新日期：1991-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance? ENaC protein has an unexpected localization in the peripheral region of the apical membrane of bronchial ...

journal_title：Experimental physiology

authors： Musante I,Scudieri P,Venturini A,Guidone D,Caci E,Castellani S,Conese M,Galietta LJV

更新日期：2019-06-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：:Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also redu...

journal_title：Experimental physiology

authors： Rajnicek AM,Gow NA,McCaig CD

更新日期：1992-01-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...

journal_title：Experimental physiology

authors： Silver J,Wadley G,Lamon S

更新日期：2018-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the role of microRNA-424-5p (miR-424-5p) in aortic smooth muscle cells? How does miR-424-5p function as a suppressor of the inflammatory response? What is the main finding and its importance? Upregulation of miR-424-5p inhibits the inflammatory response i...

journal_title：Experimental physiology

authors： Li C,Zhang M,Dai Y,Xu Z

更新日期：2020-06-01 00:00:00

abstract：:We hypothesized that exercise performance is adjusted during repeated sprints in order not to surpass a critical threshold of peripheral fatigue. Twelve men randomly performed three experimental sessions on different days, i.e. one single 10 s all-out sprint and two trials of 10 × 10 s all-out sprints with 30 s of pas...

journal_title：Experimental physiology

authors： Hureau TJ,Olivier N,Millet GY,Meste O,Blain GM

更新日期：2014-07-01 00:00:00

abstract：:Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...

journal_title：Experimental physiology

authors： Bee D,Emery CJ,Howard P

更新日期：1992-11-01 00:00:00

abstract：:Pairs of Ia and II afferent fibres supplying primary and secondary endings lying in the same tenuissimus spindles were prepared in barbiturate anaesthetized cats in order to compare the variability in the rhythm of discharge of the two endings during responses elicited by the contraction of different intrafusal muscle...

journal_title：Experimental physiology

authors： Celichowski J,Emonet-Dénand F,Gladden M,Laporte Y,Petit J

更新日期：1994-09-01 00:00:00