Abstract:
:The effects of two different feeding regimes on the 24 h profiles of maternal and fetal plasma cortisol and adrenocorticotrophic hormone (ACTH) concentrations were studied in eight pregnant ewes between 123 and 144 days of gestation. Once daily-fed ewes (n = 4) received 1 kg of lucerne-chaff at 11.00 h, and multi-fed ewes (n = 4) received 100-200 g of lucerne-chaff at 09.00, 11.00 and 13.00 h and then 150 g until 09.00 h the following day. There were significant differences between the two feeding groups in the 24 h profile of maternal plasma osmolality; once daily feeding at 11.00 h was associated with a peak in maternal plasma osmolality at 15.00 h whereas maternal plasma osmolality reached plateau levels at around 17.00 h in the multi-fed group. There were also differences between the two feeding groups in the 24 h profiles of maternal and fetal plasma glucose. Maternal and fetal plasma glucose reached peak concentrations at 19.00 h in the once daily-fed ewes in contrast to the multi-fed group, where a plateau in maternal and fetal plasma glucose was reached between 19.00 h and 09.00 h the following day. A significant diurnal variation in the plasma concentrations of cortisol was present in the once daily-fed ewes from 123 days gestation and in their fetuses after, but not before, 135 days gestation. Plasma cortisol peaked at 11.00 h in the ewes and at 13.00 h in the fetuses of this group. In the once daily-fed group there was also a significant diurnal variation in maternal and fetal plasma ACTH; plasma ACTH concentrations were highest at 11.00 h in the ewes aged between 123 and 144 days and in fetuses after 135 days gestation. In the multi-fed group, whilst ACTH was highest at 09.00 h in the ewes and at 13.00 h in the fetuses, there was no significant diurnal variation in the plasma concentrations of cortisol in the ewes or fetuses of this group at any stage between 123 and 144 days gestation.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Simonetta G,Walker DW,McMillen ICdoi
10.1113/expphysiol.1991.sp003488subject
Has Abstractpub_date
1991-03-01 00:00:00pages
219-29issue
2eissn
0958-0670issn
1469-445Xjournal_volume
76pub_type
杂志文章abstract::The results of this investigation demonstrate, using a position matching paradigm, that the ability of subjects to detect changes in the position of the proximal interphalangeal joint is impaired in patients with rheumatoid arthritis affecting this joint. In this group there is a systematic flexion bias in position ju...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003633
更新日期:1992-09-01 00:00:00
abstract::We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the app...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1993.sp003731
更新日期:1993-11-01 00:00:00
abstract::We compared the effect of age- and sex-related differences in haemodynamics, blood volume (BV) and left ventricular (LV) size and mass on resting muscle sympathetic nerve activity (MSNA) in healthy, normotensive adults. Twenty young men (19-47 years old) and 20 young women (21-46 years old) as well as 15 older men (62...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.077248
更新日期:2014-06-01 00:00:00
abstract::We recently reported that a higher percentage of type I fibres in vastus lateralis and a greater peak oxygen uptake (O2) were associated with a greater initial rise in O2 (O2 /W, where W is work rate) following the onset of heavy constant power output exercise (above the lactate threshold, LT). It was unclear if these...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? To what extent focal abdominal aortic aneurysmal (AAA) disease is associated with systemic remodelling of the vascular tree remains unknown. The present study examined whether anatomical differences exist between distances of the intervisceral artery origins and ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085804
更新日期:2016-08-01 00:00:00
abstract::Electromyographic recordings (EMGs) were made from the active masseter muscle, of the inhibitory reflex evoked by application of electrical stimuli to the skin of the upper lip in fifteen human subjects. In control sequences, the reflex had a mean latency of 42 +/- 1.1 ms and a mean duration of 45 +/- 2.1 ms. The magn...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003849
更新日期:1995-03-01 00:00:00
abstract::It is now well accepted that the sympathetic nervous system responds to specific afferent stimuli in a unique non-uniform fashion. The means by which the brain transforms the signals from a single type of receptor into an appropriate differential sympathetic output is discussed in this brief review. The detection of a...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2004.029041
更新日期:2005-03-01 00:00:00
abstract::Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2012.067421
更新日期:2013-02-01 00:00:00
abstract::Altering [K+]o might have different effects on action potential duration (APD) in myocytes from different regions. Therefore, the effects of [K+]o on regional differences in action potential characteristics were investigated in sub-endocardial, mid-myocardial and sub-epicardial myocytes isolated from the base of guine...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1111/j.1469-445x.2000.02048.x
更新日期:2000-11-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? Patients with advanced heart failure who are implanted with left ventricular assist devices (LVADs) present an opportunity to understand the human circulation under extreme conditions. What advances does it highlight? LVAD patients have a unique circulation that is charact...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088323
更新日期:2020-05-01 00:00:00
abstract::Uterine and umbilical blood flows were measured in pregnant sheep (125-142 days gestation) under normothermic and hyperthermic conditions using the Fick principle with [14C]antipyrine as the indicator. Exposure of the sheep to an ambient temperature of 43 +/- 1 degrees C (25-30% relative humidity) for 8 h increased ma...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003735
更新日期:1994-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087974
更新日期:2019-12-01 00:00:00
abstract::Disrupting circadian rhythms in rodents perturbs glucose metabolism and increases adiposity. To determine whether these effects occur in a large diurnal animal, we assessed the impact of circadian rhythm disruption upon metabolic function in sheep. Adult ewes (n = 7) underwent 3 weeks of a control 12 h light-12 h dark...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.080630
更新日期:2014-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a family history of hypertension. What is the main f...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086466
更新日期:2017-09-01 00:00:00
abstract::Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003535
更新日期:1991-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does baroreceptor unloading during passive hyperthermia contribute to increases in ventilation and decreases in end-tidal carbon dioxide during that exposure? What is the main finding and its importance? Hyperthermic hyperventilation is not mitigated by expanding...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085259
更新日期:2015-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What is the nature of slow wave-driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaux are composed of discrete waves of increased interval, each wave associated with a contraction dislocatio...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086871
更新日期:2018-08-01 00:00:00
abstract::Early vascular changes at the molecular level caused by adoption of a sedentary lifestyle are incompletely characterized. Herein, we employed the rodent wheel-lock model to identify mRNAs in the arterial wall that are responsive to the acute transition from higher to lower levels of daily physical activity. Specifical...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.066076
更新日期:2013-01-01 00:00:00
abstract::The hallmark of epithelial cells is their functional polarization. It is those membrane proteins that are distributed differentially, either to the apical or to the basal surface, that determine epithelial physiology. Such proteins will include 'pumps', 'channels' and 'carriers', and it is the functional interplay bet...
journal_title:Experimental physiology
pub_type:
doi:10.1113/expphysiol.2007.037523
更新日期:2008-03-01 00:00:00
abstract::Duchenne muscular dystrophy is a devastating muscular dystrophy of childhood. Mutations in the dystrophin gene destroy the link between the internal muscle filaments and the extracellular matrix, resulting in severe muscle weakness and progressive muscle wasting. There is currently no cure and, whilst palliative treat...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.053025
更新日期:2011-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does the magnitude of neuromuscular fatigue depend on the amount of work done (W') at task failure when cycling above critical power (CP)? What is the main finding and its importance? Creatine supplementation increases W' and enhances supra-CP performance, but in...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/EP087886
更新日期:2019-12-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086621
更新日期:2018-01-01 00:00:00
abstract::The aims of this study were: (1) to determine the within-subject, between-day variability in end-tidal P(CO2) (P(ET,CO2)); (2) to determine whether the within-subject, between-day variability in P(ET,CO2) was caused by variations in metabolic acid-base status; and (3) to determine whether between-subject variations in...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/eph8802585
更新日期:2003-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? We hypothesized that chronic mitoprotection would decrease renal vascular remodelling and dysfunction in swine metabolic syndrome. What is the main finding and its importance? This study shows that experimental metabolic syndrome exerts renal microvascular and en...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086988
更新日期:2018-07-01 00:00:00
abstract::Previously, we undertook simultaneous recording of ventilation and pulmonary gas exchange in mice and revealed that dopamine D(2) receptors participate in exercise hyperpnoea via behavioural control of ventilation with unchanged pulmonary gas exchange. Here, we examined the hypothesis that D(1) receptors also contribu...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.068312
更新日期:2013-02-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? In fever, the most striking response in the acute phase reaction of systemic inflammation, plasma H2 S concentration increases. However, the role of endogenous peripheral H2 S in fever is unknown. What is the main finding and its importance? Endogenous peripheral...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086775
更新日期:2018-03-01 00:00:00
abstract::The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin sub...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004092
更新日期:1998-01-01 00:00:00
abstract::Measurements of intracellular calcium (Ca2+i) and sodium (Na+i) have been made in single smooth muscle cells in confluent cultures of the A7r5 cell line using the Ca(2+)- and Na(+)-sensitive dyes Fura-2 and sodium-binding benzofuran isophthalate (SBFI). Reversal of the Na+ gradient in control cells results in a small ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003625
更新日期:1992-07-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? One of the major unanswered questions in physiology is that of how breathing matches metabolic rate. Venous chemoreceptors seem to have been dismissed since the 1960s. What advances does it highlight? New evidence shows that their apparent dismissal needs reappraisal. The ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086561
更新日期:2017-12-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do obesity-specific factors affect skeletal muscle performance in older individuals? What is the main finding and its importance? Older obese women have a larger quadriceps femoris size but develop lower tension per unit of skeletal muscle than their normal-weigh...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085273
更新日期:2015-10-01 00:00:00