Sex-specific effects of exercise ancestry on metabolic, morphological and gene expression phenotypes in multiple generations of mouse offspring.

abstract：:The effect of the neuronal 5-HT3 receptor antagonist MDL 72222 has been investigated on the reflex tachypnoeic response to pulmonary embolism in pentobarbitone-anaesthetized rabbits. Pre-treatment with MDL 72222 (640 micrograms kg-1, 5 min prior to embolization) significantly attenuated the reflex tachypnoeic response...

journal_title：Experimental physiology

authors： Armstrong DJ,Kay IS

更新日期：1990-07-01 00:00:00

abstract：:Power spectral analysis of heart rate variability has often been used to assess cardiac autonomic function; however, the relationship of low-frequency (LF) power of heart rate variability to cardiac sympathetic tone has been unclear. With or without adjustment for high-frequency (HF) power, total power or respiration,...

journal_title：Experimental physiology

authors： Goldstein DS,Bentho O,Park MY,Sharabi Y

更新日期：2011-12-01 00:00:00

abstract：:Plasma osteocalcin, or plasma bone GLA protein (BGP), total plasma alkaline phosphatase activity and urinary hydroxyproline excretion of twenty-four pregnant dairy cows (thirteen in their first or second pregnancy, i.e. low parity, and eleven in their third or more pregnancies, i.e. high parity) were measured from 7 w...

journal_title：Experimental physiology

authors： van Mosel M,Corlett SC

更新日期：1990-11-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Calcium is an important second messenger in eccrine sweating; however, whether modulation of extracellular Ca(2+) and Ca(2+) entry has the capacity to modulate sweat rate in non-glabrous human skin has not been explored. What is the main finding and its importanc...

journal_title：Experimental physiology

authors： Metzler-Wilson K,Sammons DL,Ossim MA,Metzger NR,Jurovcik AJ,Krause BA,Wilson TE

更新日期：2014-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review concerns the negative impact of pulmonary hypertension (PH) on the pulmonary haemodynamic and gas exchange responses to exercise, considering the mechanisms by which PH plays a role in exercise intolerance in heart failure (HF) patients. What advances does it h...

journal_title：Experimental physiology

authors： Taylor BJ,Shapiro BP,Johnson BD

更新日期：2020-02-24 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, with a prevalence of 8-12% during the reproductive years. In the present study, using prenatal exposure to a single dose of testosterone during the critical period of fetal development, we aimed to introduce an enhanced rat model ...

journal_title：Experimental physiology

authors： Tehrani FR,Noroozzadeh M,Zahediasl S,Piryaei A,Azizi F

更新日期：2014-05-01 00:00:00

abstract：:Mammalian cardiomyocytes have limited regenerative capacity, such that cell death can result in a net loss of viable contractile elements and a decrease in cardiac functional reserve, both during normal ageing and after insults to the myocardium leading to heart failure. At least four types of cell death have been des...

journal_title：Experimental physiology

authors： Goldspink DF,Burniston JG,Tan LB

更新日期：2003-05-01 00:00:00

abstract：:Luminal fluids were collected in vivo by micropuncture and cannulation from the rete testis, efferent ducts and ductus epididymidis of the rat to determine the composition of efferent duct fluids and the rates of reabsorption of water and solutes by the efferent ducts. The concentration of spermatozoa increased by a f...

journal_title：Experimental physiology

authors： Clulow J,Jones RC,Hansen LA

更新日期：1994-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is an anti-oedematous effect of ghrelin associated with increased expression of tight junction proteins in the hypoxic brain? What is the main finding and its importance? We showed that injection of ghrelin during acute and chronic systemic hypoxia is associated ...

journal_title：Experimental physiology

authors： Mohaddes G,Abdolalizadeh J,Babri S,Hossienzadeh F

更新日期：2017-03-01 00:00:00

abstract：:The effects of hypotonic solutions on intracellular Ca2+ were determined on primary cultures of human detrusor smooth muscle cells. In the presence of external Ca2+, changing from a solution containing 290 mosmol l-1 to one containing 240 mosmol l-1 (80% normal tonicity) activated a rise in intracellular Ca2+. If the ...

journal_title：Experimental physiology

authors： Chambers P,Neal DE,Gillespie JI

更新日期：1997-07-01 00:00:00

abstract：:The purpose of the present study was to characterize the Ca2+ channels in smooth muscle cells from human stomach and to examine the effects of osmotic swelling on the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier was recorded from freshly isolated smooth muscle cells using the conve...

journal_title：Experimental physiology

authors： Kim CH,Rhee PL,Rhee JC,Kim YI,So I,Kim KW,Park MK,Uhm DY,Kang TM

更新日期：2000-09-01 00:00:00

abstract：:A global and transient rise of intracellular Ca2+ (Ca2+i) is central to the operation of pump-leak coupling in the frog early distal tubule (EDT). The endoplasmic reticulum (ER) is the site of this Ca2+ release and reuptake; however, it is likely that other intracellular pools, such as mitochondria, also contribute to...

journal_title：Experimental physiology

authors： Fowler MR,Hunter M

更新日期：2005-03-01 00:00:00

abstract：:Pairs of Ia and II afferent fibres supplying primary and secondary endings lying in the same tenuissimus spindles were prepared in barbiturate anaesthetized cats in order to compare the variability in the rhythm of discharge of the two endings during responses elicited by the contraction of different intrafusal muscle...

journal_title：Experimental physiology

authors： Celichowski J,Emonet-Dénand F,Gladden M,Laporte Y,Petit J

更新日期：1994-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is electrical pulse stimulation (EPS) an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the main finding and its importance? The addition of a restitution period of 8 h after EPS induces the enlargement of human muscle cells...

journal_title：Experimental physiology

authors： Tarum J,Folkesson M,Atherton PJ,Kadi F

更新日期：2017-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...

journal_title：Experimental physiology

authors： Sharma A,Kumar V

更新日期：2019-12-01 00:00:00

abstract：:In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...

journal_title：Experimental physiology

authors： Fowden AL,Forhead AJ

更新日期：2009-06-01 00:00:00

abstract：:Joint movement was recently shown to stimulate the secretion of the lubricant hyaluronan (HA); also, exercise therapy and intra-articular hyaluronan injections are used to treat moderate osteoarthritis. The present study quantifies the stimulus-response curves for HA secretion in vivo and reports a role of transcripti...

journal_title：Experimental physiology

authors： Wann AK,Ingram KR,Coleman PJ,McHale N,Levick JR

更新日期：2009-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can targeted ablation of cardiac sympathetic neurons suppress myocardial infarction-induced adverse cardiac remodelling and left ventricular dysfunction? What is the main finding and its importance? Targeted ablation of cardiac sympathetic neurons significantly a...

journal_title：Experimental physiology

authors： Xiong L,Liu Y,Zhou M,Wang G,Quan D,Shuai W,Shen C,Kong B,Huang C,Huang H

更新日期：2018-09-01 00:00:00

abstract：:Metabolic stress is believed to constitute an important signal for training-induced adjustments of gene expression and oxidative capacity in skeletal muscle. We hypothesized that the effects of endurance training on expression of muscle-relevant transcripts and ultrastructure would be specifically modified by a hypoxi...

journal_title：Experimental physiology

authors： Schmutz S,Däpp C,Wittwer M,Durieux AC,Mueller M,Weinstein F,Vogt M,Hoppeler H,Flück M

更新日期：2010-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We examined whether the macrophage-synthesized antioxidant 7,8-dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8-dihydroneopterin could protect dystrophic skeletal mouse muscle from eccentric contraction-ind...

journal_title：Experimental physiology

authors： Lindsay A,Schmiechen A,Chamberlain CM,Ervasti JM,Lowe DA

更新日期：2018-07-01 00:00:00

abstract：:Phosphoethanolamine and taurine have been identified in uterine extracts from rat and, for the first time, human tissue. The concentration of phosphoethanolamine [PEtn] determined by HPLC and 31P NMR spectroscopy, increased markedly (40%) within the first 6-12 h following parturition in rats, suggesting a role in invo...

journal_title：Experimental physiology

authors： Phoenix J,Wray S

更新日期：1994-07-01 00:00:00

abstract：:The precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is ...

journal_title：Experimental physiology

authors： Burrell LM,Risvanis J,Johnston CI,Naitoh M,Balding LC

更新日期：2000-03-01 00:00:00

abstract：:Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...

journal_title：Experimental physiology

authors： Bee D,Emery CJ,Howard P

更新日期：1992-11-01 00:00:00

abstract：:The objective of this study was to examine the potential of stearic acid to induce cardiomyocyte cell death and the hypothesis that the amount of cellular lipid is a determinant of cell death. In cardiomyocytes from embryonic chick heart, stearic acid (SA) produced a significant (P < 0.001) concentration-dependent inc...

journal_title：Experimental physiology

authors： Rabkin SW,Lodhia P

更新日期：2009-08-01 00:00:00

abstract：:This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...

journal_title：Experimental physiology

authors： Buono MJ

更新日期：1999-03-01 00:00:00

abstract：:The physiological mechanisms contributing to sex differences following myocardial infarction (MI) are poorly understood. Given the strong relationship between sympathetic nerve activity (SNA) and outcome, we hypothesized there may be a sex difference in SNA responses to MI. In anaesthetized, open-chest male, female an...

journal_title：Experimental physiology

authors： Pinkham MI,Guild SJ,Malpas SC,Barrett CJ

更新日期：2012-09-01 00:00:00

abstract：:A sustained postexercise vasodilatation, which is histamine receptor mediated, has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistanc...

journal_title：Experimental physiology

authors： Barrett-O'Keefe Z,Kaplon RE,Halliwill JR

更新日期：2013-01-01 00:00:00

abstract：:The sympathetic neural regulation of the cerebral circulation remains controversial. The purpose of the present study was to determine how exercise modulates the simultaneous responsiveness of the cerebral and brachial circulations to 'endogenous' sympathetic activation (cold pressor test). In nine healthy subjects, h...

journal_title：Experimental physiology

authors： Hartwich D,Fowler KL,Wynn LJ,Fisher JP

更新日期：2010-11-01 00:00:00

abstract：:The effects of exogenous arginine vasotocin (AVT), isotocin (IT) and melatonin on the blood pressure of conscious Atlantic cod (Gadus morhua) were examined. Ventral aortic blood pressure (PVA) was recorded from a cannula inserted into the afferent branchial artery of the third gill arch. Dorsal aortic blood pressure (...

journal_title：Experimental physiology

authors： Kulczykowska E

更新日期：1998-11-01 00:00:00