An analysis of the action of an analogue of almitrine bismesylate in the rat model of hypoxic lung disease.

abstract：:Metabolic stress is believed to constitute an important signal for training-induced adjustments of gene expression and oxidative capacity in skeletal muscle. We hypothesized that the effects of endurance training on expression of muscle-relevant transcripts and ultrastructure would be specifically modified by a hypoxi...

journal_title：Experimental physiology

authors： Schmutz S,Däpp C,Wittwer M,Durieux AC,Mueller M,Weinstein F,Vogt M,Hoppeler H,Flück M

更新日期：2010-06-01 00:00:00

abstract：:The contractile regulation of neonatal smooth muscle was studied in rat neonatal portal vein. Strips of beta-escin-permeabilized portal vein from 3- to 5-day-old rats and 5- to 6-week-old rats were mounted on a 'bubble chamber' in calcium solutions buffered with 10 mM EGTA. Although the overall tension development was...

journal_title：Experimental physiology

authors： Bruce L,Nixon GF

更新日期：1997-11-01 00:00:00

abstract：:Beneficial effects of exercise training on the vasculature have been consistently reported in subjects with cardiovascular risk factors or disease, whereas studies in apparently healthy subjects have been less uniform. In this review, we examine evidence pertaining to the impact of exercise training on conduit and res...

journal_title：Experimental physiology

authors： Green DJ,Spence A,Halliwill JR,Cable NT,Thijssen DH

更新日期：2011-02-01 00:00:00

abstract：:Previous studies have shown that prolactin administration to pregnant rats results in offspring with enhanced abundance of the brown adipose tissue-specific uncoupling protein (UCP) 1. The present study therefore aimed to determine whether a similar effect was observed after birth and if the sex of the animal further ...

journal_title：Experimental physiology

authors： Pearce S,Dieguez C,Gualillo O,Symonds ME,Stephenson T

更新日期：2003-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Dexmedetomidine has a capacity for sedation, anti-anxiety and analgesia with minimal suppression of respiratory function; what is its role in neuropathic pain and what is the involvement of miRNAs? What is the main finding and its importance? Dexmedetomidine atte...

journal_title：Experimental physiology

authors： Zhang W,Yu T,Cui X,Yu H,Li X

更新日期：2020-09-01 00:00:00

abstract：:In humans, skeletal muscle blood flow is regulated by an interaction between several locally formed vasodilators, including NO and prostaglandins. In plasma, ATP is a potent vasodilator that stimulates the formation of NO and prostaglandins and, very importantly, can offset local sympathetic vasoconstriction. Adenosin...

journal_title：Experimental physiology

authors： Mortensen SP,Saltin B

更新日期：2014-12-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central goal of this study was to elucidate the role of magnesium in the regulation of pulmonary vascular reactivity in relationship to hypoxic pulmonary hypertension. What is the main finding and its importance? We found that magnesium is essential for norma...

journal_title：Experimental physiology

authors： Mu YP,Huang QH,Zhu JL,Zheng SY,Yan FR,Zhuang XL,Sham JSK,Lin MJ

更新日期：2018-04-01 00:00:00

abstract：:Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...

journal_title：Experimental physiology

authors： Seitz MJ,Brown R,Macefield VG

更新日期：2013-02-01 00:00:00

abstract：:To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...

journal_title：Experimental physiology

authors： Layec G,Bringard A,Yashiro K,Le Fur Y,Vilmen C,Micallef JP,Perrey S,Cozzone PJ,Bendahan D

更新日期：2012-08-01 00:00:00

abstract：:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...

journal_title：Experimental physiology

authors： Williamson JW,Fadel PJ,Mitchell JH

更新日期：2006-01-01 00:00:00

abstract：:The effects of direct autonomic nerve stimulation on the heart may be quite different to those of perfusion with pharmacological neuromodulating agents. This study was designed to investigate the effect of autonomic nerve stimulation on intracellular calcium fluorescence using fura-2 AM in the isolated Langendorff-per...

journal_title：Experimental physiology

authors： Brack KE,Coote JH,Ng GA

更新日期：2010-01-01 00:00:00

abstract：:Mammalian cardiomyocytes have limited regenerative capacity, such that cell death can result in a net loss of viable contractile elements and a decrease in cardiac functional reserve, both during normal ageing and after insults to the myocardium leading to heart failure. At least four types of cell death have been des...

journal_title：Experimental physiology

authors： Goldspink DF,Burniston JG,Tan LB

更新日期：2003-05-01 00:00:00

abstract：:Arterial pressure is regulated over long periods of time by neural, hormonal and local control mechanisms, which ultimately determine the total blood volume and how it is distributed between the various vascular compartments of the circulation. A full understanding of the complex interplay of these mechanisms can be g...

journal_title：Experimental physiology

authors： Osborn JW,Averina VA,Fink GD

更新日期：2009-04-01 00:00:00

abstract：:An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzym...

journal_title：Experimental physiology

authors： Pariente JA,Madrid JA,Salido GM

更新日期：1990-09-01 00:00:00

abstract：:Exposure to whole-body vibration is implicated as one of the occupational risk factors for lower back disorders; however, its influence on the lumbar muscle physiology is still poorly understood. The objective of this study was to investigate the effects of backrest support and hand grip contractions on lumbar muscle ...

journal_title：Experimental physiology

authors： Maikala RV,Bhambhani YN

更新日期：2006-09-01 00:00:00

abstract：:To probe the mechanisms by which respiratory syncytial virus (RSV) infection in early life forms an important risk factor for the development of chronic asthma, an airway hyper-responsiveness (AHR) animal model of guinea-pigs with persistent RSV infection was established by intranasal instillation of 2 x 10(5) plaque-...

journal_title：Experimental physiology

authors： Tan Y,Yang T,Liu S,Liu H,Xiang Y,Qu F,Li H,Qin X

更新日期：2008-12-01 00:00:00

abstract：:Neural activation decreases cerebral deoxyhaemoglobin (HHb(C)) and increases oxyhaemoglobin concentration (O(2)Hb(C)). In contrast, patients who present with restricted cerebral blood flow, such as those suffering from cerebral ischaemia or Alzheimer's disease, and during the course of ageing the converse occurs, in t...

journal_title：Experimental physiology

authors： Miyazawa T,Horiuchi M,Ichikawa D,Sato K,Tanaka N,Bailey DM,Ogoh S

更新日期：2012-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review article revisits an historical hypothesis that cerebral hypoperfusion, caused by elevated cerebral vascular resistances, causes the onset of high sympathetic nerve activity and hypertension in humans. What advances does it highlight? The review article highligh...

journal_title：Experimental physiology

authors： Hart EC

更新日期：2016-12-01 00:00:00

abstract：:Gastric distension in anaesthetized pigs reflexly elicits peripheral vasoconstriction and an increase in plasma renin activity (PRA), with vagal afferent and sympathetic efferent limbs. The aim of the present study was to quantify the contribution of the renin-angiotensin system to the peripheral vasoconstriction. In ...

journal_title：Experimental physiology

authors： Molinari C,Battaglia A,Grossini E,Florio S,Mary DA,Vassanelli C,Vacca G

更新日期：2003-05-01 00:00:00

abstract：:In anaesthetized cats, it was possible to enhance the dynamic sensitivity to stretch of jaw muscle spindle primary afferents by electrical stimulation in the midbrain. This effect was taken to be due to excitation of dynamic fusimotor neurones and was used to identify fusimotor fibres as static or dynamic in recording...

journal_title：Experimental physiology

authors： Donga R,Taylor A,Jüch PJ

更新日期：1993-01-01 00:00:00

abstract：:The endothelial glycocalyx layer of capillaries was stained with Ruthenium Red and examined by transmission electron microscopy in rat extensor hallucis proprius muscles after 2 or 4 days of indirect electrical stimulation via implanted electrodes. The layer appeared continuous on the luminal surface of 63% capillarie...

journal_title：Experimental physiology

authors： Brown MD,Egginton S,Hudlicka O,Zhou AL

更新日期：1996-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly understood. What is the main finding and its importance? Using resistance exerci...

journal_title：Experimental physiology

authors： Stöhr EJ,Stembridge M,Esformes JI

更新日期：2015-04-20 00:00:00

abstract：:Preparations of isolated rat jejunal enterocyte and brush-border and basolateral membrane vesicles have been used to study the effects of a 15 min exposure of upper and mid-villus enterocytes to pancreatic glucagon on the initial, unidirectional phlorhizin-sensitive (brush border) transport of galactose and phlorhizin...

journal_title：Experimental physiology

authors： Debnam ES,Sharp PA

更新日期：1993-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical reports have described and suggested central and peripheral respiratory abnormalities in Parkinson's disease (PD) patients; however, these reports have never addressed the occurrence of these abnormalities in an animal model. What is the main finding and...

journal_title：Experimental physiology

authors： Oliveira LM,Oliveira MA,Moriya HT,Moreira TS,Takakura AC

更新日期：2019-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We sought to understand the day-to-day variability of human indirect calorimetry during rest and exercise. Previous work has been unable to separate human day-to-day variability from measurement error and within-trial human variability. We developed models accoun...

journal_title：Experimental physiology

authors： Tenan MS,Bohannon AW,Macfarlane DJ,Crouter SE

更新日期：2018-12-01 00:00:00

abstract：:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillar...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2008-10-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

journal_title：Experimental physiology

authors： Aksentijević D,Lewis HR,Shattock MJ

更新日期：2016-02-01 00:00:00

abstract：:We measured plasma levels of L-arginine, its analogue NG-monomethyl-L-arginine (L-NMMA), and related amino acids in normal subjects and uraemic patients (n = 31), before and after haemodialysis. Plasma levels of L-arginine were reduced to less than half of normal values in uraemic subjects compared with controls, and ...

journal_title：Experimental physiology

authors： Mendes Ribeiro AC,Roberts NB,Lane C,Yaqoob M,Ellory JC

更新日期：1996-05-01 00:00:00

abstract：:Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...

journal_title：Experimental physiology

authors： Clapp LH,Gurney AM

更新日期：1991-09-01 00:00:00

abstract：:Neuropeptides and regulatory peptide hormones control many developmental, physiological and behavioural processes in animals, including humans. The nonapeptides oxytocin and arginine vasopressin are produced and released by the pituitary gland and have actions on many organs and tissues. Receptive cells possess partic...

journal_title：Experimental physiology

authors： Gruber CW

更新日期：2014-01-01 00:00:00