Abstract:
:An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzyme output were also noted after H2 antagonist cimetidine. In contrast, the H1 antagonist chlorpheniramine and H2 agonist dimaprit caused reductions in flow and enzyme output. The results suggest that H1 receptors have stimulative effects and H2 receptors have inhibitory effects on exocrine rabbit pancreas.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Pariente JA,Madrid JA,Salido GMdoi
10.1113/expphysiol.1990.sp003444subject
Has Abstractpub_date
1990-09-01 00:00:00pages
657-67issue
5eissn
0958-0670issn
1469-445Xjournal_volume
75pub_type
杂志文章abstract:NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086041
更新日期:2017-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085380
更新日期:2016-02-01 00:00:00
abstract::Fluid and electrolyte movements across the ruminal epithelium of sheep were studied using the temporarily isolated rumen technique. The sheep were all subjected to the following treatments: (1) fed sheep (fed twice daily), after rumen emptying, received rumen contents from a fed sheep; (2) food-deprived sheep (two mea...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003385
更新日期:1990-01-01 00:00:00
abstract::The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003871
更新日期:1995-07-01 00:00:00
abstract::We hypothesized that exercise performance is adjusted during repeated sprints in order not to surpass a critical threshold of peripheral fatigue. Twelve men randomly performed three experimental sessions on different days, i.e. one single 10 s all-out sprint and two trials of 10 × 10 s all-out sprints with 30 s of pas...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.077974
更新日期:2014-07-01 00:00:00
abstract::The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin sub...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004092
更新日期:1998-01-01 00:00:00
abstract::In vivo microperfusion techniques were used to investigate the role of Na+-H+ exchange in the efferent ducts of the rat. Individual efferent ducts were perfused with a Krebs-Ringer bicarbonate solution (KRB) containing 0, 1, 3, 5 or 7.5 mM amiloride. Concentrations of 1-5 mM amiloride inhibited fluid reabsorption from...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::We investigated the permeability of Cs+ and Na+ through various ion channels in rat atrial myocytes using the whole-cell voltage-clamp technique. With isotonic CsCl (140 mM) on both sides of the membrane and nominally [Ca2+]o-free conditions, depolarising clamp pulses induced an increase of outward currents which show...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Resting heart rate and heart rate variability of 33 postmenopausal women were compared with those of 50 premenopausal women of comparable activity level, none of whom had used hormone replacement therapy. Heart rate was measured as the mean of at least 600 consecutive R-R intervals obtained from electrocardiograph (EC...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract::Hypoglossal nerve activity (HNA) controls the position and movements of the tongue. In persons with compromised upper airway anatomy, sleep-related hypotonia of the tongue and other pharyngeal muscles causes increased upper airway resistance, or total upper airway obstructions, thus disrupting both sleep and breathing...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.056242
更新日期:2011-05-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? The sympathetic control of renal sodium tubular reabsorption is dependent on activation of the intrarenal renin-angiotensin system and activation of the angiotensin II type 1 (AT1 ) receptor by angiotensin II. What advances does it highlight? Despite the fact that the inte...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP085075
更新日期:2015-04-20 00:00:00
abstract::In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003656
更新日期:1992-11-01 00:00:00
abstract::It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function. The aims of this study were to compare and contrast three different mouse skeletal muscl...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.070037
更新日期:2013-04-01 00:00:00
abstract::Experiments were performed to investigate, in the normal and acutely inflamed rabbit knee joint, the role of prostaglandins in the regulation of joint blood flow, measured by laser Doppler flowmetry, as well as their modulation of sympathetic vasoconstriction. Close intra-arterial injection of prostaglandin E2 (PGE2) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003745
更新日期:1994-01-01 00:00:00
abstract::A method is described that enables the cell membrane of isolated rat ventricular myocytes to be permeabilized and resealed while maintaining cell viability. Streptolysin O, a cholesterol-binding cytolysin, was used to form pores in the surface membrane; subsequent incubation with 5% fetal bovine serum was used to reve...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004114
更新日期:1998-05-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? We examined whether the macrophage-synthesized antioxidant 7,8-dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8-dihydroneopterin could protect dystrophic skeletal mouse muscle from eccentric contraction-ind...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087031
更新日期:2018-07-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do changes in levels of angiogenesis-related mediators [vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor-κB (NF-κB)] in the sciatic nerve mediate diabetic neuropathy in the streptozotocin-induced type 1 diabetic male rat?...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088069
更新日期:2020-05-01 00:00:00
abstract::In the present study, we tested the hypothesis that chronic intermittent hypoxia (CIH) produces changes in the autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed to 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They wer...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.034868
更新日期:2006-11-01 00:00:00
abstract::The purpose of this study was to compare the kinetics of estimated capillary blood flow (Qcap) to those of femoral artery blood flow (QFA) and estimated muscle oxygen uptake (VO2m). Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee exten...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/expphysiol.2005.032904
更新日期:2006-07-01 00:00:00
abstract::An imaging technique (laser Doppler perfusion imaging, LDI), based on measurement of backscattered Doppler-broadened laser radiation, was used to provide two-dimensional images of perfusion in the exposed rat knee joint capsule. In control animals, frequency-dependent constriction of knee joint blood vessels occurred ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003851
更新日期:1995-05-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure. What is the main finding and its importance? Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087307
更新日期:2019-01-01 00:00:00
abstract::A global and transient rise of intracellular Ca2+ (Ca2+i) is central to the operation of pump-leak coupling in the frog early distal tubule (EDT). The endoplasmic reticulum (ER) is the site of this Ca2+ release and reuptake; however, it is likely that other intracellular pools, such as mitochondria, also contribute to...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2004.028886
更新日期:2005-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088203
更新日期:2020-08-01 00:00:00
abstract::The effects of muscle fatigue on the mechanical efficiency of muscle work performance were studied in situ, in stretch-shortening cycles that resembled physiological conditions. The experiments were performed on the medial gastrocnemius muscles of seven rats. To calculate efficiency, a simple Hill-type model was used,...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004001
更新日期:1997-01-01 00:00:00
abstract::Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also redu...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003580
更新日期:1992-01-01 00:00:00
abstract::This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure-volume relationship, SBP/ESV) and di...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.035089
更新日期:2007-03-01 00:00:00
abstract::Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.056416
更新日期:2011-04-01 00:00:00
abstract::Power spectral analysis of heart rate variability has often been used to assess cardiac autonomic function; however, the relationship of low-frequency (LF) power of heart rate variability to cardiac sympathetic tone has been unclear. With or without adjustment for high-frequency (HF) power, total power or respiration,...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.056259
更新日期:2011-12-01 00:00:00
abstract::Uterine and umbilical blood flows were measured in pregnant sheep (125-142 days gestation) under normothermic and hyperthermic conditions using the Fick principle with [14C]antipyrine as the indicator. Exposure of the sheep to an ambient temperature of 43 +/- 1 degrees C (25-30% relative humidity) for 8 h increased ma...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003735
更新日期:1994-01-01 00:00:00
abstract::In this study we tested the hypothesis that, compared to young adult rats, senescent rats have a reduced ability to respond to muscle unloading. Unloading of the muscles was induced by hindlimb suspension (HS) of young adult and senescent rats for 21 days. Plantaris muscles from young adult rats had significantly high...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8602235
更新日期:2001-07-01 00:00:00