Increased sensitization of the myofilaments in rat neonatal portal vein: a potential mechanism.

abstract：:Growing lambs fed a diet containing NaHCO3 were made acidotic by intravenously infusing HCl at the rate of 1 mmol/min over a 4 h period. Acid infusion led to a fall in blood and urine pH and a prompt increase in urinary Ca excretion. This in turn led to a fall in plasma Ca concentration and a rise in parathyroid hormo...

journal_title：Experimental physiology

authors： Scott D,Loveridge N,Abu Damir H,Buchan W,Milne J

更新日期：1993-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

journal_title：Experimental physiology

authors： Aksentijević D,Lewis HR,Shattock MJ

更新日期：2016-02-01 00:00:00

abstract：:The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vas...

journal_title：Experimental physiology

authors： Marutsuka K,Nawa Y,Asada Y,Hara S,Kitamura K,Eto T,Sumiyoshi A

更新日期：2001-09-01 00:00:00

abstract：:The effects of direct autonomic nerve stimulation on the heart may be quite different to those of perfusion with pharmacological neuromodulating agents. This study was designed to investigate the effect of autonomic nerve stimulation on intracellular calcium fluorescence using fura-2 AM in the isolated Langendorff-per...

journal_title：Experimental physiology

authors： Brack KE,Coote JH,Ng GA

更新日期：2010-01-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? One of the major unanswered questions in physiology is that of how breathing matches metabolic rate. Venous chemoreceptors seem to have been dismissed since the 1960s. What advances does it highlight? New evidence shows that their apparent dismissal needs reappraisal. The ...

journal_title：Experimental physiology

authors： Parkes MJ

更新日期：2017-12-01 00:00:00

abstract：:Sodium appetite, the behavioural drive to ingest salt, is stimulated by prolonged physiological sodium deficiency in many animal species. The same neural mechanisms that are responsible for sodium appetite in laboratory animals may influence human behaviour as well, with particular relevance to the dietary salt intake...

journal_title：Experimental physiology

authors： Geerling JC,Loewy AD

更新日期：2008-02-01 00:00:00

abstract：:The resonant frequency of the wrist has been measured in sixteen hypermobile and nine normal women at ten levels of peak torque. At the lowest level the results were identical but at the others the hypermobile values were lower. Damping and thixotropy appeared to be normal. In another group the grip strength of hyperm...

journal_title：Experimental physiology

authors： Walsh EG,Lambert M,Wright GW,Powers N,Nuki G

更新日期：1991-03-01 00:00:00

abstract：:Chronic heart failure (CHF) impairs muscle O2 delivery (QO2) and, at a given O2 uptake (VO2), lowers microvascular O2 pressures (PmvO2: determined by the QO2-to-VO2 ratio), which may impair recovery of high-energy phosphates following exercise. Because CHF preferentially decreases QO2 to slow-twitch muscles, we hypoth...

journal_title：Experimental physiology

authors： McDonough P,Behnke BJ,Musch TI,Poole DC

更新日期：2004-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does 14 days of live-high, train-low simulated altitude alter an individual's metabolomic/metabolic profile? What is the main finding and its importance? This study demonstrated that ∼200 h of moderate simulated altitude exposure resulted in greater variance in m...

journal_title：Experimental physiology

authors： Lawler NG,Abbiss CR,Gummer JPA,Broadhurst DI,Govus AD,Fairchild TJ,Thompson KG,Garvican-Lewis LA,Gore CJ,Maker GL,Trengove RD,Peiffer JJ

更新日期：2019-01-01 00:00:00

abstract：:The present study examined whether an increase in leg blood flow and oxygen delivery at the onset of intense exercise would speed the rate of rise in leg oxygen uptake. Nine healthy men (25 ± 1 years old, mean ± SEM) performed one-leg knee-extensor exercise (62 ± 3 W, 86 ± 3% of incremental test peak power) for 4 min ...

journal_title：Experimental physiology

authors： Nyberg M,Christensen PM,Mortensen SP,Hellsten Y,Bangsbo J

更新日期：2014-10-01 00:00:00

abstract：:Exercise induces a marked increase in interleukin-8 (IL-8) mRNA and protein expression within skeletal muscle fibres. Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif. CXC chemokines with ELR motifs are potent angiogenic factors in vivo, and IL-8 has been shown to act as an a...

journal_title：Experimental physiology

authors： Frydelund-Larsen L,Penkowa M,Akerstrom T,Zankari A,Nielsen S,Pedersen BK

更新日期：2007-01-01 00:00:00

abstract：:Simultaneous portal blood absorption and intestinal mucosal catabolism of labelled fatty acids were investigated. Anaesthetized adult Wistar rats were infused intraduodenally either with 90 mumol of capric (C10:0), oleic (C18:1), linoleic (C18:2) or arachidonic (C20:4) 1-14C acids or with 30 mumol of each labelled fat...

journal_title：Experimental physiology

authors： Bernard A,Carlier H

更新日期：1991-05-01 00:00:00

abstract：:This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (adiponectin, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2,...

journal_title：Experimental physiology

authors： Iannitti T,Graham A,Dolan S

更新日期：2012-11-01 00:00:00

abstract：:Very brief and intense exercise triggers a biphasic metabolic and respiratory response with a second phase that occurs after the cessation of the muscular activity. The effects on minute ventilation (V(E)) produced by manipulation of the peripheral circulation in metabolically active muscles could thus be studied with...

journal_title：Experimental physiology

authors： Haouzi P,Chenuel B,Chalon B

更新日期：2001-11-01 00:00:00

abstract：:Metabolic stress is believed to constitute an important signal for training-induced adjustments of gene expression and oxidative capacity in skeletal muscle. We hypothesized that the effects of endurance training on expression of muscle-relevant transcripts and ultrastructure would be specifically modified by a hypoxi...

journal_title：Experimental physiology

authors： Schmutz S,Däpp C,Wittwer M,Durieux AC,Mueller M,Weinstein F,Vogt M,Hoppeler H,Flück M

更新日期：2010-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can targeted ablation of cardiac sympathetic neurons suppress myocardial infarction-induced adverse cardiac remodelling and left ventricular dysfunction? What is the main finding and its importance? Targeted ablation of cardiac sympathetic neurons significantly a...

journal_title：Experimental physiology

authors： Xiong L,Liu Y,Zhou M,Wang G,Quan D,Shuai W,Shen C,Kong B,Huang C,Huang H

更新日期：2018-09-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review concerns the negative impact of pulmonary hypertension (PH) on the pulmonary haemodynamic and gas exchange responses to exercise, considering the mechanisms by which PH plays a role in exercise intolerance in heart failure (HF) patients. What advances does it h...

journal_title：Experimental physiology

authors： Taylor BJ,Shapiro BP,Johnson BD

更新日期：2020-02-24 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical studies suggest that obesity 'protects' against osteoporosis. However, these studies used only bone densitometry and assessed only one bone site, which is insufficient to enable conclusions to be drawn about the response of the whole skeleton. Furthermor...

journal_title：Experimental physiology

authors： Lacerda DR,Serakides R,de Melo Ocarino N,Ferreira AV,Moraes MM,Boeloni JN,Silva JF,de Oliveira MC,de Barcellos LA,Rodrigues LO,Soares DD

更新日期：2015-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the role of miR-143-3p during human dental pulp stem cell (hDPSC) differentiation. What is the main finding and its importance? miR-143-3p negatively regulates receptor activator of nuclear factor-κB (RANK). RANK ligand (RANKL) binds to RANK and stimulate...

journal_title：Experimental physiology

authors： Yang C,Jia R,Zuo Q,Zheng Y,Wu Q,Luo B,Lin P,Yin L

更新日期：2020-05-01 00:00:00

abstract：UNLABELLED:The modulation of activity of the upper airway dilator and respiratory muscles plays a key role in the regulation of ventilation, but little is known about the link between their neuromuscular activation processes in vivo. This study investigated genioglossus and diaphragm responses to transcranial magnetic ...

journal_title：Experimental physiology

authors： Wang W,Similowski T,Sériès F

更新日期：2007-07-01 00:00:00

abstract：:House dust mite (HDM) is a major source of allergen in house dust and has been suggested to be involved in the pathogenesis of asthma. In this study, we aimed to investigate whether HDM can modulate the sensitivity of pulmonary sensory neurons and, if so, to elucidate the underlying mechanism. Fura-2-based ratiometric...

journal_title：Experimental physiology

authors： Gu Q,Lee LY

更新日期：2012-04-01 00:00:00

abstract：:Uterine and umbilical blood flows were measured in pregnant sheep (125-142 days gestation) under normothermic and hyperthermic conditions using the Fick principle with [14C]antipyrine as the indicator. Exposure of the sheep to an ambient temperature of 43 +/- 1 degrees C (25-30% relative humidity) for 8 h increased ma...

journal_title：Experimental physiology

authors： Andrianakis P,Walker D

更新日期：1994-01-01 00:00:00

abstract：:A great deal of knowledge exists regarding neural control of myocardial function in the rat. Most of the studies addressing this issue were conducted either under general anaesthesia or in isolated hearts in vitro. Our principal aim was to provide a detailed quantitative description of mechanisms controlling cardiac c...

journal_title：Experimental physiology

authors： Nalivaiko E,Antunes VR,Paton JF

更新日期：2010-01-01 00:00:00

abstract：:Contraction-mediated injury is a major contributing factor to the pathophysiology of muscular dystrophy and therefore therapies that can attenuate this type of injury have clinical relevance. Systemic administration of insulin-like growth factor-I (IGF-I) has been shown to improve muscle function in dystrophic mdx mic...

journal_title：Experimental physiology

authors： Gehrig SM,Ryall JG,Schertzer JD,Lynch GS

更新日期：2008-11-01 00:00:00

abstract：:The present work reports the effect of pHo on pHi and Na(+)-H+ exchanger activity. Intracellular pH tended to follow pHo, but the proton distribution across the cell membrane is not at electrochemical equilibrium. Removal of external Na+ acidified the cells by both reversing the direction of the Na(+)-H+ exchanger and...

journal_title：Experimental physiology

authors： Peral MJ,Calonge ML,Ilundáin AA

更新日期：1995-11-01 00:00:00

abstract：:The renin-angiotensin system is activated in the early phase of two-kidney, one-clip (2K-1C) hypertension. The paraventricular nucleus (PVN) integrates inputs regulating sympathetic outflow. The PVN receives inputs from plasma angiotensin II via projections from circumventricular organs and from renal afferent nerves ...

journal_title：Experimental physiology

authors： Rossi NF,Maliszewska-Scislo M,Chen H,Black SM,Sharma S,Ravikov R,Augustyniak RA

更新日期：2010-08-01 00:00:00

abstract：:Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

journal_title：Experimental physiology

authors： Maughan RJ,Leiper JB,McGaw BA

更新日期：1990-05-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review article revisits an historical hypothesis that cerebral hypoperfusion, caused by elevated cerebral vascular resistances, causes the onset of high sympathetic nerve activity and hypertension in humans. What advances does it highlight? The review article highligh...

journal_title：Experimental physiology

authors： Hart EC

更新日期：2016-12-01 00:00:00

abstract：:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (...

journal_title：Experimental physiology

authors： Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TL

更新日期：1998-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is there sexual dimorphism in the occurrence of hepatic endoplasmic reticulum stress? What is the main finding and its importance? The transition from prepubertal to the adult age is associated with an increase in the unfolded protein response markers in the live...

journal_title：Experimental physiology

authors： Rossetti CL,de Oliveira Costa HM,Barthem CS,da Silva MH,de Carvalho DP,da-Silva WS

更新日期：2019-05-01 00:00:00