Abstract:
:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise pressor reflex and the arterial baroreflex are all requisite for eliciting appropriate cardiovascular adjustments to exercise, this review will be limited primarily to discussion of central command. Central modulation of the cardiovascular system via descending signals from higher brain centres has been well recognized for over a century, yet the specific regions of the human brain involved in this exercise-related response have remained speculative. Brain mapping studies during exercise as well as non-exercise conditions have provided information towards establishing the cerebral cortical structures in the human brain specifically involved in cardiovascular control. The purpose of this review is to provide an update of current concepts on central command in humans, with a particular emphasis on the regions of the brain identified to alter autonomic outflow and result in cardiovascular adjustments.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Williamson JW,Fadel PJ,Mitchell JHdoi
10.1113/expphysiol.2005.032037subject
Has Abstractpub_date
2006-01-01 00:00:00pages
51-8issue
1eissn
0958-0670issn
1469-445Xpii
expphysiol.2005.032037journal_volume
91pub_type
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pub_type: 临床试验,杂志文章
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