Matching of blood flow to metabolic rate during recovery from moderate exercise in humans.

Abstract:

:It is unclear whether measurement of limb or conduit artery blood flow during recovery from exercise provides an accurate representation of flow to the muscle capillaries where gas exchange occurs. To investigate this, we: (a) examined the kinetic responses of femoral artery blood flow (QFA), estimated muscle capillary blood flow (Qcap) and estimated muscle oxygen uptake (VO2m) following cessation of exercise; and (b) compared these responses to verify the adequacy of O2 delivery during recovery. Pulmonary VO2 (VO2p) was measured breath by breath, QFA was measured using Doppler ultrasonography, and deoxy-haemoglobin/myoglobin (deoxy-[Hb/Mb]) was estimated by near-infrared spectroscopy over the rectus femoris in nine healthy subjects during a series of transitions from moderate knee-extension exercise to rest. The time course of Qcap was estimated by rearranging the Fick equation [i.e. Qcap(t) alpha VO2m(t)/deoxy-[Hb/Mb](t)], using the primary component of Vo2p to represent VO2m and deoxy-[Hb/Mb] as a surrogate for arteriovenous O2 difference. There were no significant differences among the overall kinetics of VO2m (tau, 31.4+/-8.2 s), QFA [mean response time (MRT), 34.5+/-20.4 s] and Qcap (MRT, 31.7+/-14.7 s). The VO2m kinetics were also significantly correlated (P<0.05) with those of both QFA and Qcap. Both QFA and Qcap appear to be coupled with VO2m during recovery from moderate knee-extension exercise, such that extraction falls (thus cellular energetic state is not further compromised) throughout recovery.

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

doi

10.1113/expphysiol.2008.042895

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1118-25

issue

10

eissn

0958-0670

issn

1469-445X

pii

expphysiol.2008.042895

journal_volume

93

pub_type

杂志文章
  • Control of breathing and muscle perfusion in humans.

    abstract::Very brief and intense exercise triggers a biphasic metabolic and respiratory response with a second phase that occurs after the cessation of the muscular activity. The effects on minute ventilation (V(E)) produced by manipulation of the peripheral circulation in metabolically active muscles could thus be studied with...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-445x.2001.tb00041.x

    authors: Haouzi P,Chenuel B,Chalon B

    更新日期:2001-11-01 00:00:00

  • Resonant frequency at the wrist in hypermobile women.

    abstract::The resonant frequency of the wrist has been measured in sixteen hypermobile and nine normal women at ten levels of peak torque. At the lowest level the results were identical but at the others the hypermobile values were lower. Damping and thixotropy appeared to be normal. In another group the grip strength of hyperm...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1991.sp003493

    authors: Walsh EG,Lambert M,Wright GW,Powers N,Nuki G

    更新日期:1991-03-01 00:00:00

  • The increase in body weight induced by lack of methyl CpG binding protein-2 is associated with altered leptin signalling in the hypothalamus.

    abstract::Methyl CpG binding protein-2 (MECP2) is a chromatin-remodelling factor with a dual role in gene expression. Evidence from patients carrying MECP2 mutations and from transgenic mouse models demonstrates that this protein is involved in the control of body weight. However, the mechanism for this has not been fully eluci...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2014.079798

    authors: Torres-Andrade R,Moldenhauer R,Gutierrez-Bertín N,Soto-Covasich J,Mancilla-Medina C,Ehrenfeld C,Kerr B

    更新日期:2014-09-01 00:00:00

  • Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats.

    abstract::Recently, we reported the presence of a local renal aldosterone production. In the present study, we tested the hypothesis that local aldosterone production in the kidney contributes to renal inflammation, matrix formation and albuminuria associated with diabetes. We evaluated changes in renal aldosterone content (RAC...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2008.042085

    authors: Siragy HM,Xue C

    更新日期:2008-07-01 00:00:00

  • Neuronal nitric oxide synthase within paraventricular nucleus: blood pressure and baroreflex in two-kidney, one-clip hypertensive rats.

    abstract::The renin-angiotensin system is activated in the early phase of two-kidney, one-clip (2K-1C) hypertension. The paraventricular nucleus (PVN) integrates inputs regulating sympathetic outflow. The PVN receives inputs from plasma angiotensin II via projections from circumventricular organs and from renal afferent nerves ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2009.051789

    authors: Rossi NF,Maliszewska-Scislo M,Chen H,Black SM,Sharma S,Ravikov R,Augustyniak RA

    更新日期:2010-08-01 00:00:00

  • Mitochondrial regulation in skeletal muscle: A role for non-coding RNAs?

    abstract:NEW FINDINGS:What is the topic of this review? This article draws evidence from the current literature to support the hypothesis that non-coding RNA-mediated gene regulation takes place in the mitochondria. An emphasis is put on skeletal muscle. What advances does it highlight? This review highlights the potential role...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP086846

    authors: Silver J,Wadley G,Lamon S

    更新日期:2018-08-01 00:00:00

  • Stearic acid-induced cardiac lipotoxicity is independent of cellular lipid and is mitigated by the fatty acids oleic and capric acid but not by the PPAR agonist troglitazone.

    abstract::The objective of this study was to examine the potential of stearic acid to induce cardiomyocyte cell death and the hypothesis that the amount of cellular lipid is a determinant of cell death. In cardiomyocytes from embryonic chick heart, stearic acid (SA) produced a significant (P < 0.001) concentration-dependent inc...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2009.048082

    authors: Rabkin SW,Lodhia P

    更新日期:2009-08-01 00:00:00

  • Sexual dimorphism of liver endoplasmic reticulum stress susceptibility in prepubertal rats and the effect of sex steroid supplementation.

    abstract:NEW FINDINGS:What is the central question of this study? Is there sexual dimorphism in the occurrence of hepatic endoplasmic reticulum stress? What is the main finding and its importance? The transition from prepubertal to the adult age is associated with an increase in the unfolded protein response markers in the live...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087518

    authors: Rossetti CL,de Oliveira Costa HM,Barthem CS,da Silva MH,de Carvalho DP,da-Silva WS

    更新日期:2019-05-01 00:00:00

  • The effects of [K+]o on regional differences in electrical characteristics of ventricular myocytes in guinea-pig.

    abstract::Altering [K+]o might have different effects on action potential duration (APD) in myocytes from different regions. Therefore, the effects of [K+]o on regional differences in action potential characteristics were investigated in sub-endocardial, mid-myocardial and sub-epicardial myocytes isolated from the base of guine...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-445x.2000.02048.x

    authors: Wan X,Bryant SM,Hart G

    更新日期:2000-11-01 00:00:00

  • Cerebral haemodynamics and oxygenation during whole-body exercise over 5 days at high altitude.

    abstract:NEW FINDINGS:What is the central question of this study? Impairment and subsequent improvement in cerebral oxygenation during acute and prolonged exposure to high altitude affect exercise performance. This study innovates by investigating the effect of acute and prolonged high-altitude exposure on cerebral haemodynamic...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP088354

    authors: Marillier M,Rupp T,Bouzat P,Walther G,Baillieul S,Millet GY,Robach P,Verges S

    更新日期:2021-01-01 00:00:00

  • Testing the plasticity of insulin secretion and β-cell function in vivo: responses to chronic hyperglycaemia in the sheep.

    abstract::Plasticity of insulin secretion is essential to maintain the action of insulin during insulin resistance and to prevent diabetes. Investigation of the plasticity of insulin secretion and its regulation is challenging, and the objective of this study was to develop a novel large-animal-based model. The effect of chroni...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2011.063560

    authors: Gatford KL,De Blasio MJ,How TA,Harland ML,Summers-Pearce BL,Owens JA

    更新日期:2012-05-01 00:00:00

  • The effect of mechanical loading on the response of rat ventricular myocytes to acidosis.

    abstract::The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1995.sp003879

    authors: Hongo K,White E,Orchard CH

    更新日期:1995-09-01 00:00:00

  • Sympathetic innervation and beta-adrenoceptor profile of blood vessels in the posterior region of the rabbit knee joint.

    abstract::Experiments were performed to investigate the presence and nature of beta-adrenoceptors in blood vessels supplying the posterior capsule of the rabbit knee joint. Electrical stimulation of the posterior articular nerve (PAN) and close intra-arterial injection of adrenaline produced vasoconstriction which reversed to v...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1993.sp003711

    authors: Najafipour H,Ferrell WR

    更新日期:1993-09-01 00:00:00

  • Effects of exercise intensity on absorption of ingested fluids in man.

    abstract::Plasma 2H accumulation was measured in six male volunteers after ingestion of drinks containing trace amounts of 2H2O. Subjects fasted overnight and remained seated at rest or exercised on a cycle ergometer at 42, 61 or 80% of their maximum oxygen uptake (VO2, max). The rate of plasma 2H accumulation was faster at res...

    journal_title:Experimental physiology

    pub_type: 临床试验,杂志文章

    doi:10.1113/expphysiol.1990.sp003419

    authors: Maughan RJ,Leiper JB,McGaw BA

    更新日期:1990-05-01 00:00:00

  • Control of exercise hyperpnoea: Contributions from thin-fibre skeletal muscle afferents.

    abstract:NEW FINDINGS:What is the topic of this review? In this review, we examine the evidence for control mechanisms underlying exercise hyperpnoea, giving attention to the feedback from thin-fibre skeletal muscle afferents, and highlight the frequently conflicting findings and difficulties encountered by researchers using a ...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP087649

    authors: Bruce RM,Jolley C,White MJ

    更新日期:2019-11-01 00:00:00

  • Analysis and presentation of intracellular measurements obtained with ion-selective microelectrodes.

    abstract::We have considered the manner in which data obtained with ion-selective electrodes should be evaluated. The potential difference recorded by such electrodes, with respect to a stable reference, is converted to a concentration by a non-linear transformation--the Nernst or Nikolsky equation. The mean and standard deviat...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1990.sp003393

    authors: Fry CH,Hall SK,Blatter LA,McGuigan JA

    更新日期:1990-03-01 00:00:00

  • Interactions of chemostimuli at the single cell level: studies in a model system.

    abstract::The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e. how the combined effects of hypoxia and hypercapnia exert a greater effect on afferent nerve discharge than ...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/expphysiol.2003.002657

    authors: Peers C

    更新日期:2004-01-01 00:00:00

  • Non-adrenergic, non-cholinergic influences on parotid acinar degranulation in response to stimulation of the parasympathetic innervation in the anaesthetized rat.

    abstract::In pentobarbitione-anaesthetized rats the parasympathetic auriculotemporal nerve of the parotid gland was continuously stimulated at supramaximal voltage and at maximal frequency (40 Hz) for salivary secretion. The animals were pretreated with phentolamine and propranolol (2 mg kg-1 i.p. of each) and, in some groups, ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.1996.sp003994

    authors: Ekström J,Asztély A,Tobin G

    更新日期:1996-11-01 00:00:00

  • Natural killer cell mobilization and egress following acute exercise in men with prostate cancer.

    abstract:NEW FINDINGS:What is the central question of this study? What are the characteristics of the NK cell response following acute moderate-intensity aerobic exercise in prostate cancer survivors and is there a relationship between stress hormones and NK cell mobilization? What is the main finding and its importance? NK cel...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP088627

    authors: Hanson ED,Sakkal S,Que S,Cho E,Spielmann G,Kadife E,Violet JA,Battaglini CL,Stoner L,Bartlett DB,McConell GK,Hayes A

    更新日期:2020-09-01 00:00:00

  • Training-induced acceleration of O(2) uptake on-kinetics precedes muscle mitochondrial biogenesis in humans.

    abstract::The effects of 5 weeks of moderate-intensity endurance training on pulmonary oxygen uptake kinetics (V(O(2)) on-kinetics) were studied in 15 healthy men (mean ± SD: age 22.7 ± 1.8 years, body weight 76.4 ± 8.9 kg and maximal V(O(2)) 46.0 ± 3.7 ml kg(-1) min(-1)). Training caused a significant acceleration (P = 0.003) ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2012.069443

    authors: Zoladz JA,Grassi B,Majerczak J,Szkutnik Z,Korostyński M,Karasiński J,Kilarski W,Korzeniewski B

    更新日期:2013-04-01 00:00:00

  • Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle.

    abstract::Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2004.027409

    authors: Kraniou GN,Cameron-Smith D,Hargreaves M

    更新日期:2004-09-01 00:00:00

  • Consecutive transcranial magnetic stimulation twitches reduce flow limitation during sleep in apnoeic patients.

    abstract:NEW FINDINGS:What is the central question of this study? A transcranial magnetic stimulation (TMS)-induced twitch applied on isolated single breaths over the motor cortex somatotopic representation of the tongue briefly recruits submental muscles and improves airflow dynamics of flow-limited respiratory cycles without ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2013.073072

    authors: Melo-Silva CA,Gakwaya S,Rousseau E,Sériès F

    更新日期:2013-09-01 00:00:00

  • Therapeutic angiogenesis and vasculogenesis for tissue regeneration.

    abstract::Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing response by supplementation of growth factors or transplantation of vascular progenitor cells. These supplements are intended to foster the formation of arterial coll...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/expphysiol.2004.028571

    authors: Madeddu P

    更新日期:2005-05-01 00:00:00

  • Role of cyclooxygenase in the vascular responses to extremity cooling in Caucasian and African males.

    abstract:NEW FINDINGS:What is the central question of this study? Compared with Caucasians, African individuals are more susceptible to non-freezing cold injury and experience greater cutaneous vasoconstriction and cooler finger skin temperatures upon hand cooling. We investigated whether the enzyme cyclooxygenase is, in part, ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP086186

    authors: Maley MJ,House JR,Tipton MJ,Eglin CM

    更新日期:2017-07-01 00:00:00

  • Cardiac and haemodynamic influence on carotid artery longitudinal wall motion.

    abstract:NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP086621

    authors: Au JS,Bochnak PA,Valentino SE,Cheng JL,Stöhr EJ,MacDonald MJ

    更新日期:2018-01-01 00:00:00

  • The integrity of the FOG-2 LXCXE pRb-binding motif is required for small intestine homeostasis.

    abstract:NEW FINDINGS:What is the central question of this study? Do Fog2Rb-/Rb- mice present a defect of small intestine homeostasis? What is the main finding and its importance? The importance of interactions between FOG-2 and pRb in adipose tissue physiology has previously been demonstrated. Here it is shown that this intera...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/EP087369

    authors: Goupille O,Kadri Z,Langelé A,Luccantoni S,Badoual C,Leboulch P,Chrétien S

    更新日期:2019-07-01 00:00:00

  • Sweat ethanol concentrations are highly correlated with co-existing blood values in humans.

    abstract::This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...

    journal_title:Experimental physiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Buono MJ

    更新日期:1999-03-01 00:00:00

  • Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea.

    abstract::What is the topic of this review? This article presents emerging evidence for heightened carotid body chemoreflex activity as a major driver of sympathetic activation and hypertension in sleep apnoea patients. What advances does it heighlight? This article discusses the recent advances on cellular, molecular and epige...

    journal_title:Experimental physiology

    pub_type: 杂志文章,评审

    doi:10.1113/EP085624

    authors: Prabhakar NR

    更新日期:2016-08-01 00:00:00

  • Laryngeal movements during the respiratory cycle measured with an endoscopic imaging technique in the conscious horse at rest.

    abstract::A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:

    authors: Lafortuna CL,Albertini M,Ferrucci F,Zucca E,Braghieri M,Clement MG,Saibene F

    更新日期:1999-07-01 00:00:00

  • The role of the subfornical organ in angiotensin II-salt hypertension in the rat.

    abstract::Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is dependent, in part, on increased activity of the sympathetic nervous system. This chronic sympathoexcitatory response is amplified by a high-salt diet, suggesting an interaction of circulating Ang II and dietary salt on sympa...

    journal_title:Experimental physiology

    pub_type: 杂志文章

    doi:10.1113/expphysiol.2011.060491

    authors: Osborn JW,Hendel MD,Collister JP,Ariza-Guzman PA,Fink GD

    更新日期:2012-01-01 00:00:00