Abstract:
:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, caused a decrease in plasma luteinizing hormone (LH) after 15 and 60 days of immobilization and in plasma testosterone after 60 days, but produced an opposite androgenic response in pubertal animals (15 days of immobilization). A persumed sympathetic over-stimulation is suggested to account for increased testosterone levels in pubertal stressed rats.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TLdoi
10.1113/expphysiol.1998.sp004151subject
Has Abstractpub_date
1998-09-01 00:00:00pages
701-4issue
5eissn
0958-0670issn
1469-445Xjournal_volume
83pub_type
杂志文章abstract:NEW FINDINGS:What is the central question of this study? Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure. What is the main finding and its importance? Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087307
更新日期:2019-01-01 00:00:00
abstract::Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2004.027409
更新日期:2004-09-01 00:00:00
abstract::The role of bicarbonate as a hydrogen ion buffer has been investigated using the fluorescent dye BCECF in individual rat cerebellar, hippocampal and neocortical neurones maintained in culture. The steady-state intracellular pH (pHi) was estimated to be 7.07 +/- 0.05 (n = 22) in CO2-HCO3(-)-buffered media. Buffering po...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1996.sp003963
更新日期:1996-07-01 00:00:00
abstract::Early life and preconception environmental stimuli can affect adult health-related phenotypes. Exercise training is an environmental stimulus affecting many systems throughout the body and appears to alter offspring phenotypes. The aim of this study was to examine the influence of parental exercise training, or 'exerc...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.070300
更新日期:2013-10-01 00:00:00
abstract::The effects of muscle fatigue on the mechanical efficiency of muscle work performance were studied in situ, in stretch-shortening cycles that resembled physiological conditions. The experiments were performed on the medial gastrocnemius muscles of seven rats. To calculate efficiency, a simple Hill-type model was used,...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004001
更新日期:1997-01-01 00:00:00
abstract::The cardiovascular response to isometric exercise is governed by both central and peripheral mechanisms. Both metabolic and mechanical stresses on the exercising skeletal muscle produce cardiovascular change, yet it is often overlooked that the afferent signal arising from the muscle can be modified by factors other t...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2004.028639
更新日期:2004-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do GABA receptors play any role at the neuromuscular junction? What is the main finding and its importance? In the presence of either ionotropic or metabotropic GABA receptor antagonists, diaphragm muscle force production elicited by stimulating the motor nerve a...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087611
更新日期:2019-07-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Dexmedetomidine has a capacity for sedation, anti-anxiety and analgesia with minimal suppression of respiratory function; what is its role in neuropathic pain and what is the involvement of miRNAs? What is the main finding and its importance? Dexmedetomidine atte...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088596
更新日期:2020-09-01 00:00:00
abstract::The effects of exogenous arginine vasotocin (AVT), isotocin (IT) and melatonin on the blood pressure of conscious Atlantic cod (Gadus morhua) were examined. Ventral aortic blood pressure (PVA) was recorded from a cannula inserted into the afferent branchial artery of the third gill arch. Dorsal aortic blood pressure (...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004161
更新日期:1998-11-01 00:00:00
abstract::Aortic bodies are arterial chemoreceptors presumed to monitor blood O2 content by unknown mechanisms, in contrast to their well-studied carotid body counterparts, which monitor PO2 and /pH. We recently showed that rat aortic body chemoreceptors (type I cells), located at the left vagus-recurrent laryngeal nerve bifurc...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.075408
更新日期:2014-01-01 00:00:00
abstract::Neural mediation of the human cardiac response to isocapnic (IC) steady-state hypoxaemia was investigated using coarse-graining spectral analysis of heart rate variability (HRV). Six young adults were exposed in random order to a hypoxia or control protocol, in supine and sitting postures, while end-tidal PCO2 (PET,CO...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2000-03-01 00:00:00
abstract::Simultaneous portal blood absorption and intestinal mucosal catabolism of labelled fatty acids were investigated. Anaesthetized adult Wistar rats were infused intraduodenally either with 90 mumol of capric (C10:0), oleic (C18:1), linoleic (C18:2) or arachidonic (C20:4) 1-14C acids or with 30 mumol of each labelled fat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003511
更新日期:1991-05-01 00:00:00
abstract::Non-invasive autonomic evaluation has used fast Fourier transform (FFT) to assign a range of low (LF) and high frequencies (HF) as markers of sympathetic and parasympathetic influences, respectively. However, FFT cannot be applied to brief transient phenomena, such as those observed on performing autonomic tests where...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.038026
更新日期:2007-07-01 00:00:00
abstract::We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min(1) H...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.053090
更新日期:2010-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do changes in levels of angiogenesis-related mediators [vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor-κB (NF-κB)] in the sciatic nerve mediate diabetic neuropathy in the streptozotocin-induced type 1 diabetic male rat?...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088069
更新日期:2020-05-01 00:00:00
abstract::The dorsal horn of the spinal cord plays an important role in transmitting information from nociceptive primary afferent neurones to the brain; however, our knowledge of its neuronal and synaptic organisation is still limited. Nociceptive afferents terminate mainly in laminae I and II and some of these contain substan...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/eph8702351
更新日期:2002-03-01 00:00:00
abstract::What is the central question of this study? Can a modern proportional assist ventilator (PAV) function sufficiently well to unload the respiratory muscles during exercise? What is the main finding and its importance? A PAV can be constructed with contemporary hardware and software and be used at all exercise intensiti...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085735
更新日期:2016-06-01 00:00:00
abstract::Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.056416
更新日期:2011-04-01 00:00:00
abstract::The precise role of vasopressin in the pathophysiology of cardiovascular disease is controversial, but this peptide hormone is important for several reasons. Firstly, circulating concentrations of vasopressin are elevated in heart failure and some forms of hypertension. Secondly, there is evidence that vasopressin is ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1469-445x.2000.tb00031.x
更新日期:2000-03-01 00:00:00
abstract::Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2005.031708
更新日期:2006-01-01 00:00:00
abstract::This study compared the concentration of ethanol, both absolute and relative to water content, in sweat and blood. Ten male volunteers consumed approximately 13 mmol (kg body weight)-1 of ethanol. Blood and sweat samples were collected approximately 1, 2 and 3 h following ingestion. Sweat was collected following piloc...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Is an anti-oedematous effect of ghrelin associated with increased expression of tight junction proteins in the hypoxic brain? What is the main finding and its importance? We showed that injection of ghrelin during acute and chronic systemic hypoxia is associated ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086068
更新日期:2017-03-01 00:00:00
abstract::Recent studies showed that progesterone stimulates the hypoxic ventilatory response and may reduce apnoea frequency in newborn rats, but so far we still do not know by what mechanisms and whether endogenous progesterone might contribute to respiratory control in neonates. We therefore determined the role of the nuclea...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.080986
更新日期:2014-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Impairment and subsequent improvement in cerebral oxygenation during acute and prolonged exposure to high altitude affect exercise performance. This study innovates by investigating the effect of acute and prolonged high-altitude exposure on cerebral haemodynamic...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088354
更新日期:2021-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Exercise for type 2 diabetes patients treated with insulin therapy involves the risk of hypoglycaemia. Dipeptidyl peptidase-4 (DPP-4) inhibitors can be effective in combination with exercise because they reduce the incidence of hypoglycaemia. We evaluated the eff...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087449
更新日期:2019-07-01 00:00:00
abstract::This study was designed to investigate the putative neurophysiological effects of so-called 'H-wave therapy' (HWT), a form of electrical stimulation, upon conduction latencies in the human superficial radial nerve. Antidromic compound action potentials were recorded from the superficial radial nerve in the dominant fo...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1113/expphysiol.1996.sp003979
更新日期:1996-09-01 00:00:00
abstract::Disrupting circadian rhythms in rodents perturbs glucose metabolism and increases adiposity. To determine whether these effects occur in a large diurnal animal, we assessed the impact of circadian rhythm disruption upon metabolic function in sheep. Adult ewes (n = 7) underwent 3 weeks of a control 12 h light-12 h dark...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.080630
更新日期:2014-09-01 00:00:00
abstract::One of the most basic computational elements within a circuit is the synapse across which signals are transferred. Here we summarize some experimental strategies that allow the synaptic basis of circuit function to be studied through imaging. The two most promising approaches available currently are pHluorin-based rep...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2009.051953
更新日期:2011-01-01 00:00:00
abstract::Oxidants have been suggested to enhance contractile function in unfatigued muscle. In this study we aimed to determine the effect of oxidants on "chemically skinned" diaphragm muscle fibre bundles. The sarcoplasmic reticulum and contractile proteins were exposed to superoxide anions (O2-) and hydrogen peroxide (H2O2) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8602109
更新日期:2001-03-01 00:00:00
abstract::The purpose of the present study was to characterize the Ca2+ channels in smooth muscle cells from human stomach and to examine the effects of osmotic swelling on the channel activity. Ca2+ channel current with either Ca2+ or Ba2+ as charge carrier was recorded from freshly isolated smooth muscle cells using the conve...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1017/s0958067000020133
更新日期:2000-09-01 00:00:00