Chronic intermittent immobilization of male rats throughout sexual development: a stress protocol.

Abstract:

:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, caused a decrease in plasma luteinizing hormone (LH) after 15 and 60 days of immobilization and in plasma testosterone after 60 days, but produced an opposite androgenic response in pubertal animals (15 days of immobilization). A persumed sympathetic over-stimulation is suggested to account for increased testosterone levels in pubertal stressed rats.

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TL

doi

10.1113/expphysiol.1998.sp004151

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

701-4

issue

5

eissn

0958-0670

issn

1469-445X

journal_volume

83

pub_type

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