The effects of age and hindlimb supension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal muscles.

abstract：:Transport of a number of dipolar amino acids (and the orally active antibiotic D-cycloserine) across the apical membrane of human intestinal epithelial (Caco-2) cell monolayers is mediated by a Na+-independent, pH-dependent transport mechanism. Relatively little is known about the mode of action of this transport syst...

journal_title：Experimental physiology

authors： Thwaites DT,Stevens BC

更新日期：1999-03-01 00:00:00

abstract：:Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...

journal_title：Experimental physiology

authors： Bee D,Emery CJ,Howard P

更新日期：1992-11-01 00:00:00

abstract：:A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...

journal_title：Experimental physiology

authors： Lafortuna CL,Albertini M,Ferrucci F,Zucca E,Braghieri M,Clement MG,Saibene F

更新日期：1999-07-01 00:00:00

abstract：:Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units i...

journal_title：Experimental physiology

authors： Wallis WR,Wu C,Sheridan DJ,Fry CH

更新日期：1997-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly understood. What is the main finding and its importance? Using resistance exerci...

journal_title：Experimental physiology

authors： Stöhr EJ,Stembridge M,Esformes JI

更新日期：2015-04-20 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review concerns the negative impact of pulmonary hypertension (PH) on the pulmonary haemodynamic and gas exchange responses to exercise, considering the mechanisms by which PH plays a role in exercise intolerance in heart failure (HF) patients. What advances does it h...

journal_title：Experimental physiology

authors： Taylor BJ,Shapiro BP,Johnson BD

更新日期：2020-02-24 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does a previously hypothesized signalling mechanism, believed to detect postprandial increases in intestinal phosphate and that can stimulate the kidneys to rapidly excrete phosphate, operate under physiological conditions? What is the main finding and its import...

journal_title：Experimental physiology

authors： Lee GJ,Mossa-Al Hashimi L,Debnam ES,Unwin RJ,Marks J

更新日期：2017-04-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article describes the contribution of oxidative stress and pro-inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia. What advances does it highlight? Chronic in...

journal_title：Experimental physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2015-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What are the characteristics of the NK cell response following acute moderate-intensity aerobic exercise in prostate cancer survivors and is there a relationship between stress hormones and NK cell mobilization? What is the main finding and its importance? NK cel...

journal_title：Experimental physiology

authors： Hanson ED,Sakkal S,Que S,Cho E,Spielmann G,Kadife E,Violet JA,Battaglini CL,Stoner L,Bartlett DB,McConell GK,Hayes A

更新日期：2020-09-01 00:00:00

abstract：:Recently attempts have been made to analyse blood pressure (BP) and renal sympathetic nerve activity (RSNA) to determine how patterns contained within them might reflect control by the autonomic nervous system. To date, these studies have primarily used coherence analysis of BP and RSNA in the frequency domain. Howeve...

journal_title：Experimental physiology

authors： Yang Z,Zhang T,Coote JH

更新日期：2002-07-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：:Flow of submandibular saliva and the constituents secreted during chorda-lingual nerve stimulation at 40 Hz (3 x 10 min) were studied after alpha- and beta-adrenergic blockade, and in the absence (control) or presence of cholinergic blockade in anaesthetized rats. Peroxidase and true tissue kallikrein (rK1) were asses...

journal_title：Experimental physiology

authors： Garrett JR,Anderson LC,Zhang XS,Proctor GB

更新日期：1996-05-01 00:00:00

abstract：:The effects of two different feeding regimes on the 24 h profiles of maternal and fetal plasma cortisol and adrenocorticotrophic hormone (ACTH) concentrations were studied in eight pregnant ewes between 123 and 144 days of gestation. Once daily-fed ewes (n = 4) received 1 kg of lucerne-chaff at 11.00 h, and multi-fed ...

journal_title：Experimental physiology

authors： Simonetta G,Walker DW,McMillen IC

更新日期：1991-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Oestradiol (E2 ) plays an important role in regulating skeletal muscle strength in females. To what extent does E2 deficiency affect recovery of strength and satellite cell number when muscle is challenged by multiple injuries? What is the main finding and its im...

journal_title：Experimental physiology

authors： Larson AA,Baumann CW,Kyba M,Lowe DA

更新日期：2020-10-01 00:00:00

abstract：:An imaging technique (laser Doppler perfusion imaging, LDI), based on measurement of backscattered Doppler-broadened laser radiation, was used to provide two-dimensional images of perfusion in the exposed rat knee joint capsule. In control animals, frequency-dependent constriction of knee joint blood vessels occurred ...

journal_title：Experimental physiology

authors： Karimian SM,McDougall JJ,Ferrell WR

更新日期：1995-05-01 00:00:00

abstract：:Experiments were performed to investigate the presence and nature of beta-adrenoceptors in blood vessels supplying the posterior capsule of the rabbit knee joint. Electrical stimulation of the posterior articular nerve (PAN) and close intra-arterial injection of adrenaline produced vasoconstriction which reversed to v...

journal_title：Experimental physiology

authors： Najafipour H,Ferrell WR

更新日期：1993-09-01 00:00:00

abstract：:Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...

journal_title：Experimental physiology

authors： Lesniewska V,Rowland I,Laerke HN,Grant G,Naughton PJ

更新日期：2006-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...

journal_title：Experimental physiology

authors： Spiller PF,da Silva CAA,Francescato HDC,Moraes DJA

更新日期：2020-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provide...

journal_title：Experimental physiology

authors： Zhu Y,Wu Y,Yang L,Dou X,Jiang J,Wang L

更新日期：2019-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Rate-pressure product (RPP) is commonly used as an index of cardiac 'effort'. In canine and human hearts (which have a positive force-frequency relationship), RPP is linearly correlated with oxygen consumption and has therefore been widely adopted as a species-in...

journal_title：Experimental physiology

authors： Aksentijević D,Lewis HR,Shattock MJ

更新日期：2016-02-01 00:00:00

abstract：:In anaesthetized cats, it was possible to enhance the dynamic sensitivity to stretch of jaw muscle spindle primary afferents by electrical stimulation in the midbrain. This effect was taken to be due to excitation of dynamic fusimotor neurones and was used to identify fusimotor fibres as static or dynamic in recording...

journal_title：Experimental physiology

authors： Donga R,Taylor A,Jüch PJ

更新日期：1993-01-01 00:00:00

abstract：:Exercise induces a marked increase in interleukin-8 (IL-8) mRNA and protein expression within skeletal muscle fibres. Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif. CXC chemokines with ELR motifs are potent angiogenic factors in vivo, and IL-8 has been shown to act as an a...

journal_title：Experimental physiology

authors： Frydelund-Larsen L,Penkowa M,Akerstrom T,Zankari A,Nielsen S,Pedersen BK

更新日期：2007-01-01 00:00:00

abstract：:We investigated the permeability of Cs+ and Na+ through various ion channels in rat atrial myocytes using the whole-cell voltage-clamp technique. With isotonic CsCl (140 mM) on both sides of the membrane and nominally [Ca2+]o-free conditions, depolarising clamp pulses induced an increase of outward currents which show...

journal_title：Experimental physiology

authors： Youm JB,Ho WK,Earm YE

更新日期：2000-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Can targeted ablation of cardiac sympathetic neurons suppress myocardial infarction-induced adverse cardiac remodelling and left ventricular dysfunction? What is the main finding and its importance? Targeted ablation of cardiac sympathetic neurons significantly a...

journal_title：Experimental physiology

authors： Xiong L,Liu Y,Zhou M,Wang G,Quan D,Shuai W,Shen C,Kong B,Huang C,Huang H

更新日期：2018-09-01 00:00:00

abstract：:House dust mite (HDM) is a major source of allergen in house dust and has been suggested to be involved in the pathogenesis of asthma. In this study, we aimed to investigate whether HDM can modulate the sensitivity of pulmonary sensory neurons and, if so, to elucidate the underlying mechanism. Fura-2-based ratiometric...

journal_title：Experimental physiology

authors： Gu Q,Lee LY

更新日期：2012-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary ad...

journal_title：Experimental physiology

authors： Mosca EV,Rousseau JP,Gulemetova R,Kinkead R,Wilson RJ

更新日期：2015-02-01 00:00:00

abstract：:A sustained postexercise vasodilatation, which is histamine receptor mediated, has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistanc...

journal_title：Experimental physiology

authors： Barrett-O'Keefe Z,Kaplon RE,Halliwill JR

更新日期：2013-01-01 00:00:00

abstract：:The sympathetic neural regulation of the cerebral circulation remains controversial. The purpose of the present study was to determine how exercise modulates the simultaneous responsiveness of the cerebral and brachial circulations to 'endogenous' sympathetic activation (cold pressor test). In nine healthy subjects, h...

journal_title：Experimental physiology

authors： Hartwich D,Fowler KL,Wynn LJ,Fisher JP

更新日期：2010-11-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? Brown fat's role in meal-associated thermogenesis and the related consequences for energy balance regulation with a focus on the gut hormone secretin, which has been identified as the endocrine molecular mediator of meal-associated brown fat thermogenesis. What advances do...

journal_title：Experimental physiology

authors： Schnabl K,Li Y,Klingenspor M

更新日期：2020-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does 14 days of live-high, train-low simulated altitude alter an individual's metabolomic/metabolic profile? What is the main finding and its importance? This study demonstrated that ∼200 h of moderate simulated altitude exposure resulted in greater variance in m...

journal_title：Experimental physiology

authors： Lawler NG,Abbiss CR,Gummer JPA,Broadhurst DI,Govus AD,Fairchild TJ,Thompson KG,Garvican-Lewis LA,Gore CJ,Maker GL,Trengove RD,Peiffer JJ

更新日期：2019-01-01 00:00:00