Abstract:
:Despite its critical role in restoring cardiac rhythm and thus in saving human life, cardiac defibrillation remains poorly understood. Further mechanistic inquiry is hampered by the inability of presently available experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth of the ventricles. The objective of this review article is to demonstrate that realistic 3-D simulations of the ventricular defibrillation process in close conjunction with experimental observations are capable of bringing a new level of understanding of the electrical events that ensue from the interaction between fibrillating myocardium and applied shock. The article does this by reviewing the results of two studies, one on vulnerability to electric shocks and another on defibrillation. An overview of the modelling tools used in these studies is also provided.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Trayanova Ndoi
10.1113/expphysiol.2005.030973subject
Has Abstractpub_date
2006-03-01 00:00:00pages
323-37issue
2eissn
0958-0670issn
1469-445Xpii
expphysiol.2005.030973journal_volume
91pub_type
杂志文章,评审abstract::Uterine and umbilical blood flows were measured in pregnant sheep (125-142 days gestation) under normothermic and hyperthermic conditions using the Fick principle with [14C]antipyrine as the indicator. Exposure of the sheep to an ambient temperature of 43 +/- 1 degrees C (25-30% relative humidity) for 8 h increased ma...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003735
更新日期:1994-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What is the role of miR-143-3p during human dental pulp stem cell (hDPSC) differentiation. What is the main finding and its importance? miR-143-3p negatively regulates receptor activator of nuclear factor-κB (RANK). RANK ligand (RANKL) binds to RANK and stimulate...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087992
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abstract:NEW FINDINGS:What is the central question of this study? In fever, the most striking response in the acute phase reaction of systemic inflammation, plasma H2 S concentration increases. However, the role of endogenous peripheral H2 S in fever is unknown. What is the main finding and its importance? Endogenous peripheral...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086775
更新日期:2018-03-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This review provides a comprehensive overview of Nox5 from basic biology to human disease and highlights unique features of this Nox isoform What advances does it highlight? Major advances in Nox5 biology relate to crystallization of the molecule and new insights into the ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086204
更新日期:2019-05-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Exercise for type 2 diabetes patients treated with insulin therapy involves the risk of hypoglycaemia. Dipeptidyl peptidase-4 (DPP-4) inhibitors can be effective in combination with exercise because they reduce the incidence of hypoglycaemia. We evaluated the eff...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087449
更新日期:2019-07-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This brief review discusses potential sex differences in arterial function across the age span, with special emphasis on the effects of oestrogen and testosterone on the vascular endothelium. What advances does it highlight? We discuss the relationship between the impacts ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
abstract::We hypothesized that exercise performance is adjusted during repeated sprints in order not to surpass a critical threshold of peripheral fatigue. Twelve men randomly performed three experimental sessions on different days, i.e. one single 10 s all-out sprint and two trials of 10 × 10 s all-out sprints with 30 s of pas...
journal_title:Experimental physiology
pub_type: 杂志文章
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abstract::Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa. Intestinal reelin and Dab1 mRNA levels were maximal in the early stages of life, reaching adult levels in 1-month-...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.050682
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abstract::Appreciation for the role of aldosterone and mineralocorticoid receptors in cardiovascular disease is accelerating rapidly. Recent experimental work has unveiled a strong relationship between brain mineralocorticoid receptors and sympathetic drive, an important determinant of outcome in heart failure and hypertension....
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2008.045948
更新日期:2010-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do Fog2Rb-/Rb- mice present a defect of small intestine homeostasis? What is the main finding and its importance? The importance of interactions between FOG-2 and pRb in adipose tissue physiology has previously been demonstrated. Here it is shown that this intera...
journal_title:Experimental physiology
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doi:10.1113/EP087369
更新日期:2019-07-01 00:00:00
abstract::The inward transport of two purines, adenosine and hypoxanthine, at 37 degrees C by horse erythrocytes was compared. No mediated transport of adenosine was detected in horse erythrocytes, nor was saturable, high-affinity binding of the potent facilitated-diffusion inhibitor nitrobenzylthioinosine demonstrable in horse...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004104
更新日期:1998-03-01 00:00:00
abstract::Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2005.031708
更新日期:2006-01-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This review describes the role of renal nerves as the key carrier of signals from the kidneys to the CNS and vice versa; the brain and kidneys communicate through this carrier to maintain homeostasis in the body. What advances does it highlight? Whether renal or autonomic ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2014.079889
更新日期:2015-04-20 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does baroreceptor unloading during passive hyperthermia contribute to increases in ventilation and decreases in end-tidal carbon dioxide during that exposure? What is the main finding and its importance? Hyperthermic hyperventilation is not mitigated by expanding...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085259
更新日期:2015-11-01 00:00:00
abstract::Changes in tension of slow motor units in the medial gastrocnemius muscle of the rat were measured and compared in three fatigue tests, each of 4 min duration. In one of these tests motor unit tetani were evoked by repeated trains of stimuli of the standard frequency, 40 Hz, while in other tests frequencies of 20 and ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003907
更新日期:1995-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Is electrical pulse stimulation (EPS) an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the main finding and its importance? The addition of a restitution period of 8 h after EPS induces the enlargement of human muscle cells...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086581
更新日期:2017-11-01 00:00:00
abstract::In this review we discuss our current understanding of the cellular basis of uterine contractility, highlighting those areas requiring further study. It is clear that the basic processes of excitation-contraction coupling lie within the myometrial cell, and that these may be modified by agonists. Pacemaker activity, h...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/eph8602114
更新日期:2001-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What is the precise subcellular localization of the epithelial sodium channel (ENaC) in human airway epithelium? What is the main finding and its importance? ENaC protein has an unexpected localization in the peripheral region of the apical membrane of bronchial ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087590
更新日期:2019-06-01 00:00:00
abstract::In pentobarbitione-anaesthetized rats the parasympathetic auriculotemporal nerve of the parotid gland was continuously stimulated at supramaximal voltage and at maximal frequency (40 Hz) for salivary secretion. The animals were pretreated with phentolamine and propranolol (2 mg kg-1 i.p. of each) and, in some groups, ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1996.sp003994
更新日期:1996-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What is the carotid bodies' contribution to active inspiratory and expiratory response to exercise? What is the main finding and its importance? Removal of the carotid bodies reduced the active inspiratory and expiratory responses of diaphragm and abdominal inter...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088203
更新日期:2020-08-01 00:00:00
abstract::The purpose of the present study was to investigate the effect of temperature on the rates of isometric force development and relaxation in electrically activated fresh and fatigued human adductor pollicis muscle. Following immersion of the lower arm for 20 min in water baths of four different temperatures, muscle tem...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1017/s0958067099018953
更新日期:1999-11-01 00:00:00
abstract::Lateral ventricular volumes were monitored and quantified using accurately registered magnetic resonance images (MRIs) in six healthy individuals 30 min before and up to 4 h after ingestion of a glucose drink. The volume of the lateral ventricles increased by an average (+/- S.E.M.) of 2.4 +/- 0.4% as blood glucose le...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1111/j.1469-445x.1999.tb00085.x
更新日期:1999-01-01 00:00:00
abstract::The role of testosterone (T) in the regulation of cardiovascular function in females is not well understood. Our goal was to examine the effect of T on cardiomyocyte biology by measuring sarcomere shortening/relaxation and intracellular calcium cycling in adult female Sprague-Dawley rats. The rats were divided into th...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.067009
更新日期:2013-01-01 00:00:00
abstract::Luminal fluids were collected in vivo by micropuncture and cannulation from the rete testis, efferent ducts and ductus epididymidis of the rat to determine the composition of efferent duct fluids and the rates of reabsorption of water and solutes by the efferent ducts. The concentration of spermatozoa increased by a f...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003817
更新日期:1994-11-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does 14 days of live-high, train-low simulated altitude alter an individual's metabolomic/metabolic profile? What is the main finding and its importance? This study demonstrated that ∼200 h of moderate simulated altitude exposure resulted in greater variance in m...
journal_title:Experimental physiology
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更新日期:2019-01-01 00:00:00
abstract::Transport of a number of dipolar amino acids (and the orally active antibiotic D-cycloserine) across the apical membrane of human intestinal epithelial (Caco-2) cell monolayers is mediated by a Na+-independent, pH-dependent transport mechanism. Relatively little is known about the mode of action of this transport syst...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::The effects of direct autonomic nerve stimulation on the heart may be quite different to those of perfusion with pharmacological neuromodulating agents. This study was designed to investigate the effect of autonomic nerve stimulation on intracellular calcium fluorescence using fura-2 AM in the isolated Langendorff-per...
journal_title:Experimental physiology
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doi:10.1113/expphysiol.2009.048215
更新日期:2010-01-01 00:00:00
abstract::Tumour cell survival is intimately related to blood vessel function and so the tumour vasculature represents a novel target for cancer therapy. We have investigated a murine tumour model in which a metal clamp was used to occlude the vascular supply temporarily and then removed to allow reperfusion. This allows the st...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
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更新日期:1997-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? We present a new non-invasive medical technology, the inspired sine-wave technique, which involves inhalation of sinusoidally fluctuating concentrations of a tracer gas. The technique requires only passive patient cooperation and can monitor different cardiorespi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086867
更新日期:2018-05-01 00:00:00
abstract::Embryonic stem (ES) cells are pluripotent cells isolated from the inner cell mass of blastocysts. ES cells are able to differentiate into the three primitive layers (endoderm, mesoderm and ectoderm) of the organism, including the germline. To study early stages of development, as well as to investigate the impact of a...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00