Abstract:
:The effects of the bacterial toxin Escherichia coli STa on electrogenic secretion in proximal, mid and distal rat colon were examined in vitro using the short-circuit current (Isc) as an index of secretion. All areas showed toxin-elevated Isc which was reduced by bumetanide. The proximal colon was the most sensitive (lowest ED50) but displayed the lowest maximal increase in Isc, the mid colon had the largest maximal electrogenic response while the distal colon proved to be the least sensitive (highest ED50). Atropine (1 microM) and tetrodotoxin (1.25 microM) reduced the maximum Isc response to STa by up to 42%, indicating that the enteric nervous system may be partly involved in the response.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Young A,Levin RJdoi
10.1113/expphysiol.1991.sp003561subject
Has Abstractpub_date
1991-11-01 00:00:00pages
979-82issue
6eissn
0958-0670issn
1469-445Xjournal_volume
76pub_type
杂志文章abstract::The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vas...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8602250
更新日期:2001-09-01 00:00:00
abstract::Transport of a number of dipolar amino acids (and the orally active antibiotic D-cycloserine) across the apical membrane of human intestinal epithelial (Caco-2) cell monolayers is mediated by a Na+-independent, pH-dependent transport mechanism. Relatively little is known about the mode of action of this transport syst...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides benefits over a standard welfare scoring system for ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.083139
更新日期:2015-02-01 00:00:00
abstract::Early vascular changes at the molecular level caused by adoption of a sedentary lifestyle are incompletely characterized. Herein, we employed the rodent wheel-lock model to identify mRNAs in the arterial wall that are responsive to the acute transition from higher to lower levels of daily physical activity. Specifical...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.066076
更新日期:2013-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary ad...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.082180
更新日期:2015-02-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? The role of the cerebral haemodynamic response to either normobaric or hypobaric hypoxia in people susceptible to acute mountain sickness (AMS) is still under debate. Prefrontal cortex near-infrared spectroscopy-derived parameters were monitored in normobaric hyp...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088515
更新日期:2021-01-01 00:00:00
abstract::Beneficial effects of exercise training on the vasculature have been consistently reported in subjects with cardiovascular risk factors or disease, whereas studies in apparently healthy subjects have been less uniform. In this review, we examine evidence pertaining to the impact of exercise training on conduit and res...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2009.048694
更新日期:2011-02-01 00:00:00
abstract::Non-invasive autonomic evaluation has used fast Fourier transform (FFT) to assign a range of low (LF) and high frequencies (HF) as markers of sympathetic and parasympathetic influences, respectively. However, FFT cannot be applied to brief transient phenomena, such as those observed on performing autonomic tests where...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.038026
更新日期:2007-07-01 00:00:00
abstract::There is controversy about the effect of left ventricular pressure on resistance of the intramyocardial coronary vessels. In anaesthetized dogs the effect of left ventricular pressure on coronary flow during diastole was studied using an extracorporeal circulation and allowing the heart to contract and relax isovolumi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003602
更新日期:1992-03-01 00:00:00
abstract::House dust mite (HDM) is a major source of allergen in house dust and has been suggested to be involved in the pathogenesis of asthma. In this study, we aimed to investigate whether HDM can modulate the sensitivity of pulmonary sensory neurons and, if so, to elucidate the underlying mechanism. Fura-2-based ratiometric...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.060764
更新日期:2012-04-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This review provides a comprehensive overview of Nox5 from basic biology to human disease and highlights unique features of this Nox isoform What advances does it highlight? Major advances in Nox5 biology relate to crystallization of the molecule and new insights into the ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086204
更新日期:2019-05-01 00:00:00
abstract::Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also redu...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003580
更新日期:1992-01-01 00:00:00
abstract::Electromyographic recordings (EMGs) were made from the active masseter muscle, of the inhibitory reflex evoked by application of electrical stimuli to the skin of the upper lip in fifteen human subjects. In control sequences, the reflex had a mean latency of 42 +/- 1.1 ms and a mean duration of 45 +/- 2.1 ms. The magn...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003849
更新日期:1995-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086621
更新日期:2018-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? We present a new non-invasive medical technology, the inspired sine-wave technique, which involves inhalation of sinusoidally fluctuating concentrations of a tracer gas. The technique requires only passive patient cooperation and can monitor different cardiorespi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086867
更新日期:2018-05-01 00:00:00
abstract::Haemorrhagic shock (HS) and fluid resuscitation can lead to increased reactive oxygen species (ROS), contributing to ischaemia-reperfusion injury and organ damage. Ubiquinol is a potent antioxidant that decreases ROS. This study examined the effects of ubiquinol administered with fluid resuscitation following controll...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.078600
更新日期:2014-07-01 00:00:00
abstract::The present study was designed to analyse the effects of aerobic exercise on the metabolic effects of alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight)(-1)) intraperitoneally (A rats). Vehicle-injected rats were used as controls (C rats). At 28 days old, some of the A rats were s...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2004.028241
更新日期:2005-01-01 00:00:00
abstract::Aldosterone influences the kidney's regulation of blood pressure (BP), but aldosterone can contribute to the pathogenesis of hypertension. Blood pressure is reduced with aerobic exercise training (AEX), but the extent to which plasma aldosterone (PA) levels change is unclear. The purpose of this study was to determine...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.037408
更新日期:2007-09-01 00:00:00
abstract::We have examined the effect of a hyposmotic shock, and thus cell swelling, upon the efflux of amino acids, SO4(2-) and I- from lactating mammary tissue. A hyposmotic challenge increased the efflux of taurine and glycine via a 4,4'-diisothiocyanatostilbene-2,2'- disulphonic acid (DIDS)-sensitive pathway. It appears tha...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003808
更新日期:1994-09-01 00:00:00
abstract::It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function. The aims of this study were to compare and contrast three different mouse skeletal muscl...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.070037
更新日期:2013-04-01 00:00:00
abstract::The vascular actions of insulin are complex, because it can stimulate both nitric oxide-mediated dilatation and endothelin (ET)-1-mediated constriction. We examined vasoreactivity to insulin in isolated feed arteries of the gastrocnemius (GFA) and soleus muscles (SFA) of 32-week-old Long-Evans Tokushima Otsuka (LETO) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.074047
更新日期:2014-01-01 00:00:00
abstract::The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e. how the combined effects of hypoxia and hypercapnia exert a greater effect on afferent nerve discharge than ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2003.002657
更新日期:2004-01-01 00:00:00
abstract::The hypothalamus regulates the key hormonal signalling events essential for reproduction and fertility in mammals. The gonadotrophin-releasing hormone (GnRH) neurons are the principal neurons of the complex neuronal network that co-ordinates multiple internal homeostatic and external factors necessary for fertility. K...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2013.071944
更新日期:2013-11-01 00:00:00
abstract::The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasocons...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003871
更新日期:1995-07-01 00:00:00
abstract::Recently attempts have been made to analyse blood pressure (BP) and renal sympathetic nerve activity (RSNA) to determine how patterns contained within them might reflect control by the autonomic nervous system. To date, these studies have primarily used coherence analysis of BP and RSNA in the frequency domain. Howeve...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1111/j.1469-445x.2002.tb00059.x
更新日期:2002-07-01 00:00:00
abstract::The dorsal horn of the spinal cord plays an important role in transmitting information from nociceptive primary afferent neurones to the brain; however, our knowledge of its neuronal and synaptic organisation is still limited. Nociceptive afferents terminate mainly in laminae I and II and some of these contain substan...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/eph8702351
更新日期:2002-03-01 00:00:00
abstract::The effect of mechanical loading on the negative inotropic effect of acidosis in isolated rat ventricular myocytes was investigated. The mechanical loading of the myocytes was changed by attaching carbon fibres to the ends of the cell. To monitor intracellular Ca2+ and Na+ concentrations, cells were loaded with fluore...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003879
更新日期:1995-09-01 00:00:00
abstract::What is the central question of this study? Neurocognitive functions can be enhanced by acute aerobic exercise, which could be associated with changes in serum brain-derived neurotrophic factor (BDNF) concentrations. We aimed to explore acute exercise-induced changes in BDNF concentrations, neuropsychological and neur...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085682
更新日期:2016-07-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086041
更新日期:2017-09-01 00:00:00
abstract::Moderate-intensity endurance exercise training improves vascular endothelial vasomotor function; however, the impact of high-intensity exercise training has been equivocal. Thus, the effect of the physiological stress of the exercise remains poorly understood. Furthermore, enhanced vascular repair mediated by circulat...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/expphysiol.2011.062836
更新日期:2012-03-01 00:00:00