Abstract:
:The hypotensive and vasorelaxing peptides adrenomedullin (AM) and its gene-related peptide, proadrenomedullin N-terminal 20 peptide (PAMP), were found to be distributed on the surface of the colonic mucosa. AM and PAMP showed dose-dependent antimicrobial activity against E. coli. The results suggest that the novel vasoactive peptides AM and PAMP play an important role in mucosal defence.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Marutsuka K,Nawa Y,Asada Y,Hara S,Kitamura K,Eto T,Sumiyoshi Adoi
10.1113/eph8602250subject
Has Abstractpub_date
2001-09-01 00:00:00pages
543-5issue
5eissn
0958-0670issn
1469-445Xpii
EPH_2250journal_volume
86pub_type
杂志文章abstract::Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2012.067421
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abstract::An imaging technique (laser Doppler perfusion imaging, LDI), based on measurement of backscattered Doppler-broadened laser radiation, was used to provide two-dimensional images of perfusion in the exposed rat knee joint capsule. In control animals, frequency-dependent constriction of knee joint blood vessels occurred ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003851
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abstract::In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...
journal_title:Experimental physiology
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doi:10.1113/expphysiol.1992.sp003656
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abstract::The neurohypophysial hormone vasopressin contributes to control of urine output and, while urine flow shows a clear daily rhythm, there has been debate as to whether this is true of neurohypophysial hormones. A study was performed on fifteen adult males, with a mean age of 25 years, over a 24 h period, nine blood samp...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004124
更新日期:1998-05-01 00:00:00
abstract::A global and transient rise of intracellular Ca2+ (Ca2+i) is central to the operation of pump-leak coupling in the frog early distal tubule (EDT). The endoplasmic reticulum (ER) is the site of this Ca2+ release and reuptake; however, it is likely that other intracellular pools, such as mitochondria, also contribute to...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2004.028886
更新日期:2005-03-01 00:00:00
abstract::Despite its critical role in restoring cardiac rhythm and thus in saving human life, cardiac defibrillation remains poorly understood. Further mechanistic inquiry is hampered by the inability of presently available experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2005.030973
更新日期:2006-03-01 00:00:00
abstract::We have examined the surface ultrastructure and morphological characteristics of leucocytes obtained from control rats breathing air and rats made acutely hypoxic (breathing 6% O2, for 30 min). Striking ultrastructural and morphological changes occurred in the leucocytes of hypoxic rats. These changes included the app...
journal_title:Experimental physiology
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更新日期:1993-11-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? In this review, we examine the evidence for control mechanisms underlying exercise hyperpnoea, giving attention to the feedback from thin-fibre skeletal muscle afferents, and highlight the frequently conflicting findings and difficulties encountered by researchers using a ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP087649
更新日期:2019-11-01 00:00:00
abstract::The nucleus tractus solitarii (NTS) is a key central link in control of multiple homeostatic reflexes. A number of studies have demonstrated that exogenous and endogenous nitric oxide (NO) within NTS regulates visceral function, but further understanding of the role of NO in the NTS is hampered by the lack of informat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.036103
更新日期:2007-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087974
更新日期:2019-12-01 00:00:00
abstract::Disrupting circadian rhythms in rodents perturbs glucose metabolism and increases adiposity. To determine whether these effects occur in a large diurnal animal, we assessed the impact of circadian rhythm disruption upon metabolic function in sheep. Adult ewes (n = 7) underwent 3 weeks of a control 12 h light-12 h dark...
journal_title:Experimental physiology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
abstract::The objective of the experiments was to investigate the cellular basis of the inotropic effect on myocardium of several opioids which have been implicated in producing cardiotoxic effects in human poisoning. Opioids exerted negative inotropic effects, with half-maximal concentrations between 10 microM (dextropropoxyph...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004021
更新日期:1997-03-01 00:00:00
abstract::What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would sho...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085716
更新日期:2016-07-01 00:00:00
abstract::Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units i...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004011
更新日期:1997-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Glucose is the dominant energy source for the brain. However, little is known about how glucose metabolism impacts the coordination of network activity in the brain in healthy adults. What is the main finding and its importance? We demonstrate that both alpha osc...
journal_title:Experimental physiology
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doi:10.1113/EP089211
更新日期:2021-01-28 00:00:00
abstract::Experiments were carried out to examine the perceived position of the human index finger about the proximal interphalangeal joint. In protocol I, the finger was moved from an intermediate position at velocities ranging from 200 deg/min to 2 deg/min, then held still at one of three positions. The subject's task was vis...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003592
更新日期:1992-03-01 00:00:00
abstract::Adenosine 5'-triphosphate (ATP) is a cotransmitter with classical transmitters in most nerves in the peripheral and central nervous systems, although the proportions vary between tissues and species and in different developmental and pathophysiological circumstances. There was early evidence that ATP was released toge...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2008.043620
更新日期:2009-01-01 00:00:00
abstract::An investigation was made of the effects of H1 and H2 receptor agonists and antagonists on rabbit pancreatic exocrine secretion stimulated by secretin and cholecystokinin (CCK). The H1 agonist 2-thiazolylethylamine elicited dose-dependent increases in the rate of secretion. Increases in pancreatic juice flow and enzym...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003444
更新日期:1990-09-01 00:00:00
abstract::Rats were fed a liquid diet with the aim of decreasing nervous reflex activity in the parotid glands. In rats killed after 21 days on this diet the glands were atrophied and the total amounts of the neuropeptides, substance P, vasoactive intestinal peptide and calcitonin gene-related peptide, were lower than in contro...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003435
更新日期:1990-07-01 00:00:00
abstract::What is the central question of this study? Can a modern proportional assist ventilator (PAV) function sufficiently well to unload the respiratory muscles during exercise? What is the main finding and its importance? A PAV can be constructed with contemporary hardware and software and be used at all exercise intensiti...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085735
更新日期:2016-06-01 00:00:00
abstract::Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses o...
journal_title:Experimental physiology
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doi:10.1113/expphysiol.1992.sp003648
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2007.040485
更新日期:2008-03-01 00:00:00
abstract::Branched fibres are a well-documented phenomenon of regenerating skeletal muscle. They are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe condition of progressive muscle wasting caused by an absence of the sarcolemmal protein dystrophin, and in the muscles of the mdx mouse, an animal mod...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.056713
更新日期:2011-06-01 00:00:00
abstract::This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral artery was dissected. After 30 min of monitoring, the hearts were isolated and subjected to 30 min...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2012.066217
更新日期:2013-02-01 00:00:00
abstract::The purpose of this study was to compare the kinetics of estimated capillary blood flow (Qcap) to those of femoral artery blood flow (QFA) and estimated muscle oxygen uptake (VO2m). Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee exten...
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pub_type: 临床试验,杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.1997.sp004031
更新日期:1997-03-01 00:00:00
abstract:NEW FINDINGS:What is the central question of the study? What are the effects of age and fitness on the vascular response to acute inflammation in younger and older adults? What is the main finding and its importance? In older adults, cardiorespiratory fitness level has a differential impact on endothelial function afte...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086922
更新日期:2018-06-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Dexmedetomidine has a capacity for sedation, anti-anxiety and analgesia with minimal suppression of respiratory function; what is its role in neuropathic pain and what is the involvement of miRNAs? What is the main finding and its importance? Dexmedetomidine atte...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088596
更新日期:2020-09-01 00:00:00
abstract::In mammals, including man, epidemiological and experimental studies have shown that a range of environmental factors acting during critical periods of early development can alter adult phenotype. Hormones have an important role in these epigenetic modifications and can signal the type, severity and duration of the env...
journal_title:Experimental physiology
pub_type:
doi:10.1113/expphysiol.2008.046359
更新日期:2009-06-01 00:00:00
abstract::This review explores the current concepts relating the structural and functional modifications of skeletal muscle mitochondria to the molecular mechanisms activated when organisms are exposed to a hypoxic environment. In contrast to earlier assumptions it is now established that permanent or long-term exposure to seve...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/eph8802513
更新日期:2003-01-01 00:00:00