Intracellular pH and H+ buffering capacity in guinea-pigs with left ventricular hypertrophy induced by constriction of the thoracic aorta.

Abstract:

:Intracellular pH (pHi) was measured in left ventricular myocytes from hearts hypertrophied by constriction of the thoracic aorta. There was a continuous relation between an increase in heart-to-body weight ratio and a decrease in pHi (mean +/- S.D., 7.06 +/- 0.18 pH units in control hearts vs. 6.87 +/- 0.17 pH units in hypertrophied hearts). Intracellular H+ buffering capacity (beta) increased as pHi fell, but the value of beta was independent of hypertrophy per se.

journal_name

Exp Physiol

journal_title

Experimental physiology

authors

Wallis WR,Wu C,Sheridan DJ,Fry CH

doi

10.1113/expphysiol.1997.sp004011

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

227-30

issue

1

eissn

0958-0670

issn

1469-445X

journal_volume

82

pub_type

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