Abstract：
:The pathogenesis of the vasodilatation associated with liver cirrhosis is not fully understood, but it has recently been postulated that it may be related to an increase in nitric oxide production. The aim of this study was to compare the response of isolated aortic rings from normal and cirrhotic rats to two vasoconstrictors, phenylephrine and U46619, a thromboxane analogue. Biliary cirrhosis was induced by ligation of the common bile duct; a sham operation was performed in control animals. Five weeks later, the aorta was removed and dissected into rings for study in organ chambers. Concentration-response curves were obtained for the two vasoconstrictors from rings with intact endothelium and from rings denuded of endothelium. We found that the vasoconstriction produced by phenylephrine was decreased in cirrhotic vessels both with and without endothelium, but the response to U46619 was not modified by cirrhosis. Concentration-response curves for phenylephrine were also obtained from rings in which the synthesis of nitric oxide and prostaglandins was inhibited by NG-monomethyl-L-arginine and indomethacin, respectively. Nitric oxide synthase inhibition restored normal contractility of the rings with and without endothelium. This beneficial effect was not observed when cyclo-oxygenase activity was blocked with indomethacin. This study suggests that cirrhotic vessels are hyporeactive to vasoconstrictors and that this effect is mediated through increased nitric oxide production. The improvement observed after inhibition of the nitric oxide pathway in denuded rings led us to suggest that cirrhosis also induces nitric oxide synthase in smooth muscle cells, as previously observed by others in septic animals.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Van Obbergh L,Leonard V,Chen H,Xu D,Blaise Gdoi
10.1113/expphysiol.1995.sp003871subject
Has Abstractpub_date
1995-07-01 00:00:00pages
609-17issue
4eissn
0958-0670issn
1469-445Xjournal_volume
80pub_type
杂志文章abstract：:Changes in tension of slow motor units in the medial gastrocnemius muscle of the rat were measured and compared in three fatigue tests, each of 4 min duration. In one of these tests motor unit tetani were evoked by repeated trains of stimuli of the standard frequency, 40 Hz, while in other tests frequencies of 20 and ...
journal_title：Experimental physiology
pub_type： 杂志文章
doi：10.1113/expphysiol.1995.sp003907
更新日期：1995-11-01 00:00:00
abstract：:The hallmark of epithelial cells is their functional polarization. It is those membrane proteins that are distributed differentially, either to the apical or to the basal surface, that determine epithelial physiology. Such proteins will include 'pumps', 'channels' and 'carriers', and it is the functional interplay bet...
journal_title：Experimental physiology
pub_type：
doi：10.1113/expphysiol.2007.037523
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journal_title：Experimental physiology
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Experimental physiology
pub_type： 杂志文章
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更新日期：1993-11-01 00:00:00
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journal_title：Experimental physiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Experimental physiology
pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
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更新日期：2014-01-01 00:00:00
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journal_title：Experimental physiology
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-07-01 00:00:00
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更新日期：2020-10-02 00:00:00
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journal_title：Experimental physiology
pub_type： 杂志文章
doi：10.1113/expphysiol.1996.sp003919
更新日期：1996-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Experimental physiology
pub_type： 杂志文章
doi：10.1113/expphysiol.1993.sp003694
更新日期：1993-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-04-01 00:00:00
