Facts, fantasies and fun in epithelial physiology.

abstract：NEW FINDINGS:What is the topic of this review? I focus on clinical aspects of uterine physiology, specifically, myometrial contractility. I bring together and contrast findings using physiological approaches and those using newer techniques, 'omics'. What advances does it highlight? Physiological studies have recently ...

journal_title：Experimental physiology

authors： Wray S

更新日期：2015-12-01 00:00:00

abstract：:Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When it is administered orally to suckling rats, it induces maturation of the intestinal tract (liver, pancreas and small intestine). Here we show that this polyamine is able to induce precocious intestinal and splenic develo...

journal_title：Experimental physiology

authors： Jolois O,Peulen O,Collin S,Simons M,Dandrifosse G,Heinen E

更新日期：2002-01-01 00:00:00

abstract：:The present study investigated the absolute reliability (R(Ab)) of isometric measures of time-to-peak tension (TTP), half-rise time ((1/2)RT), half-fall time ((1/2)FT), twitch force (TW(f)) tetanic force (TET(f)) and the sag ratio as applied to the slow soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) ...

journal_title：Experimental physiology

authors： Gallo M,Gordon T,Tyreman N,Shu Y,Putman CT

更新日期：2004-09-01 00:00:00

abstract：:Current assessments of the effects of shear patterns on vascular function assume that a parabolic velocity profile is always present. Any substantial deviation in the profile away from this may result in misinterpretation of the importance that shear patterns have on vascular function. The present investigation tested...

journal_title：Experimental physiology

authors： Ade CJ,Broxterman RM,Wong BJ,Barstow TJ

更新日期：2012-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do Fog2Rb-/Rb- mice present a defect of small intestine homeostasis? What is the main finding and its importance? The importance of interactions between FOG-2 and pRb in adipose tissue physiology has previously been demonstrated. Here it is shown that this intera...

journal_title：Experimental physiology

authors： Goupille O,Kadri Z,Langelé A,Luccantoni S,Badoual C,Leboulch P,Chrétien S

更新日期：2019-07-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Carotid artery longitudinal wall motion (CALM) is a bidirectional forward and backward motion of the arterial wall; however, there is no evidence in humans for what controls CALM despite proposals for pulse pressure, left ventricular motion and shear rate. What i...

journal_title：Experimental physiology

authors： Au JS,Bochnak PA,Valentino SE,Cheng JL,Stöhr EJ,MacDonald MJ

更新日期：2018-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Loss of taste or inability to distinguish between different tastes progresses with age. The purpose was to evaluate the age-dependent changes in taste by studying the electrophysiological properties of taste receptor cells. What is the main finding and its import...

journal_title：Experimental physiology

authors： Takeuchi K,Yoshii K,Ohtubo Y

更新日期：2020-11-10 00:00:00

abstract：:The present study examined whether an increase in leg blood flow and oxygen delivery at the onset of intense exercise would speed the rate of rise in leg oxygen uptake. Nine healthy men (25 ± 1 years old, mean ± SEM) performed one-leg knee-extensor exercise (62 ± 3 W, 86 ± 3% of incremental test peak power) for 4 min ...

journal_title：Experimental physiology

authors： Nyberg M,Christensen PM,Mortensen SP,Hellsten Y,Bangsbo J

更新日期：2014-10-01 00:00:00

abstract：:Recently, we reported the presence of a local renal aldosterone production. In the present study, we tested the hypothesis that local aldosterone production in the kidney contributes to renal inflammation, matrix formation and albuminuria associated with diabetes. We evaluated changes in renal aldosterone content (RAC...

journal_title：Experimental physiology

authors： Siragy HM,Xue C

更新日期：2008-07-01 00:00:00

abstract：:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...

journal_title：Experimental physiology

authors： Williamson JW,Fadel PJ,Mitchell JH

更新日期：2006-01-01 00:00:00

abstract：:The renal medulla contains more mRNA of the inducible isoform of nitric oxide synthase (iNOS) than the cortex, which may be important in preventing ischaemic injury, since blood flow and tissue oxygen tension are normally low in this region. We examined the effects of the bacterial endotoxin E. coli lipopolysaccharide...

journal_title：Experimental physiology

authors： Chou DE,Cai H,Jayadevappa D,Porush JG

更新日期：2002-03-01 00:00:00

abstract：:Neural activation decreases cerebral deoxyhaemoglobin (HHb(C)) and increases oxyhaemoglobin concentration (O(2)Hb(C)). In contrast, patients who present with restricted cerebral blood flow, such as those suffering from cerebral ischaemia or Alzheimer's disease, and during the course of ageing the converse occurs, in t...

journal_title：Experimental physiology

authors： Miyazawa T,Horiuchi M,Ichikawa D,Sato K,Tanaka N,Bailey DM,Ogoh S

更新日期：2012-02-01 00:00:00

abstract：:It is unknown whether changes in corticomotor excitability follow prolonged exercise in healthy humans. Furthermore, the role of supraspinal fatigue in decrements of force production and voluntary activation following prolonged exercise has not been established. This study investigated peripheral and central fatigue a...

journal_title：Experimental physiology

authors： Ross EZ,Middleton N,Shave R,George K,Nowicky A

更新日期：2007-03-01 00:00:00

abstract：:To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...

journal_title：Experimental physiology

authors： Layec G,Bringard A,Yashiro K,Le Fur Y,Vilmen C,Micallef JP,Perrey S,Cozzone PJ,Bendahan D

更新日期：2012-08-01 00:00:00

abstract：:This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral artery was dissected. After 30 min of monitoring, the hearts were isolated and subjected to 30 min...

journal_title：Experimental physiology

authors： Donato M,Buchholz B,Rodríguez M,Pérez V,Inserte J,García-Dorado D,Gelpi RJ

更新日期：2013-02-01 00:00:00

abstract：:Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...

journal_title：Experimental physiology

authors： Clapp LH,Gurney AM

更新日期：1991-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do obesity-specific factors affect skeletal muscle performance in older individuals? What is the main finding and its importance? Older obese women have a larger quadriceps femoris size but develop lower tension per unit of skeletal muscle than their normal-weigh...

journal_title：Experimental physiology

authors： Rastelli F,Capodaglio P,Orgiu S,Santovito C,Caramenti M,Cadioli M,Falini A,Rizzo G,Lafortuna CL

更新日期：2015-10-01 00:00:00

abstract：:Despite its critical role in restoring cardiac rhythm and thus in saving human life, cardiac defibrillation remains poorly understood. Further mechanistic inquiry is hampered by the inability of presently available experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth...

journal_title：Experimental physiology

authors： Trayanova N

更新日期：2006-03-01 00:00:00

abstract：:In order to investigate the effect of chronic sodium depletion on renal proximal tubular reabsorption, studies were performed in conscious, unrestrained Brattleboro rats. Since these animals lack circulating vasopressin, fractional water reabsorption in the distal nephron can be assumed to be constant and changes in u...

journal_title：Experimental physiology

authors： Shirley DG,Skinner J

更新日期：1994-03-01 00:00:00

abstract：:Oxidants have been suggested to enhance contractile function in unfatigued muscle. In this study we aimed to determine the effect of oxidants on "chemically skinned" diaphragm muscle fibre bundles. The sarcoplasmic reticulum and contractile proteins were exposed to superoxide anions (O2-) and hydrogen peroxide (H2O2) ...

journal_title：Experimental physiology

authors： Darnley GM,Duke AM,Steele DS,MacFarlane NG

更新日期：2001-03-01 00:00:00

abstract：:The effect of resistance training on arterial stiffening is controversial. We tested the hypothesis that resistance training would not alter central arterial compliance. Young healthy men (age, 23 +/- 3.9 (mean +/- s.e.m.) years; n = 28,) were whole-body resistance trained five times a week for 12 weeks, using a rotat...

journal_title：Experimental physiology

authors： Rakobowchuk M,McGowan CL,de Groot PC,Bruinsma D,Hartman JW,Phillips SM,MacDonald MJ

更新日期：2005-07-01 00:00:00

abstract：:The properties of two types of calcium current (ICa(T) and ICa(L)) and their relationship with contraction were studied in isolated frog atrial trabeculae using the double mannitol gap technique. In Ringer solution containing TTX the calcium currents observed are similar to the ICa(T) and ICa(L) found in single frog a...

journal_title：Experimental physiology

authors： Badaoui A,Léoty C

更新日期：1994-09-01 00:00:00

abstract：:Joint movement was recently shown to stimulate the secretion of the lubricant hyaluronan (HA); also, exercise therapy and intra-articular hyaluronan injections are used to treat moderate osteoarthritis. The present study quantifies the stimulus-response curves for HA secretion in vivo and reports a role of transcripti...

journal_title：Experimental physiology

authors： Wann AK,Ingram KR,Coleman PJ,McHale N,Levick JR

更新日期：2009-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is electrical pulse stimulation (EPS) an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the main finding and its importance? The addition of a restitution period of 8 h after EPS induces the enlargement of human muscle cells...

journal_title：Experimental physiology

authors： Tarum J,Folkesson M,Atherton PJ,Kadi F

更新日期：2017-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central question of this study was to investigate the interaction of mild exposures to O2 and CO2 on chemoreflex control of SNA and the modulation of lung volume and respiratory phase on this interaction. What is the main finding and its importance? We demons...

journal_title：Experimental physiology

authors： Jouett NP,Watenpaugh DE,Dunlap ME,Smith ML

更新日期：2015-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? In fever, the most striking response in the acute phase reaction of systemic inflammation, plasma H2 S concentration increases. However, the role of endogenous peripheral H2 S in fever is unknown. What is the main finding and its importance? Endogenous peripheral...

journal_title：Experimental physiology

authors： Soriano RN,Braga SP,Breder JSC,Batalhao ME,Oliveira-Pelegrin GR,Ferreira LFR,Rocha MJA,Carnio EC,Branco LGS

更新日期：2018-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does treatment of obstructive sleep apnoea (OSA) with nocturnal oxygen or continuous positive airway pressure (CPAP) improve hypoxic vascular responses, which are reportedly impaired in OSA? What is the main finding and its importance? Cerebrovascular and cardiov...

journal_title：Experimental physiology

authors： Beaudin AE,Hanly PJ,Raneri JK,Sajobi TT,Anderson TJ,Poulin MJ

更新日期：2019-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We investigated whether 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) could prevent acute increases in body fat and changes in omental and subcutaneous adipose tissue following the sudden transition from physical activity to physical inactivity. ...

journal_title：Experimental physiology

authors： Ruegsegger GN,Sevage JA,Childs TE,Grigsby KB,Booth FW

更新日期：2017-11-01 00:00:00

abstract：:Oscillations in the cardiovascular system have been observed in patients with periodic breathing. It is not clear whether these are driven by primary oscillations in the respiratory system or whether an intrinsic cardiovascular instability is required, as previous studies with subjects performing voluntary periodic br...

journal_title：Experimental physiology

authors： Davies LC,Francis DP,Crisafulli A,Concu A,Coats AJ,Piepoli M

更新日期：2000-11-01 00:00:00

abstract：:In quiescent papillary muscles isolated from hearts of rats with streptozotocin-induced diabetes resting intracellular sodium activity (aiNa) was about 56% greater than in muscles from controls. An intracellular acid load induced by the NH4+ method caused a rise in aiNa whose maximum amplitude was similar in both grou...

journal_title：Experimental physiology

authors： Lagadic-Gossmann D,Feuvray D

更新日期：1991-01-01 00:00:00