Anterograde and retrograde blood velocity profiles in the intact human cardiovascular system.

abstract：NEW FINDINGS:What is the central question of this study? Do GABA receptors play any role at the neuromuscular junction? What is the main finding and its importance? In the presence of either ionotropic or metabotropic GABA receptor antagonists, diaphragm muscle force production elicited by stimulating the motor nerve a...

journal_title：Experimental physiology

authors： Lenina O,Petrov K,Kovyazina I,Malomouzh A

更新日期：2019-07-01 00:00:00

abstract：:To better understand the mechanisms underlying the pulmonary O(2) uptake (V(O(2P))) slow component during high-intensity exercise, we used (31)P magnetic resonance spectroscopy, gas exchange, surface electromyography and near-infrared spectroscopy measurements to examine the potential relationship between the slow com...

journal_title：Experimental physiology

authors： Layec G,Bringard A,Yashiro K,Le Fur Y,Vilmen C,Micallef JP,Perrey S,Cozzone PJ,Bendahan D

更新日期：2012-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? What is the main fin...

journal_title：Experimental physiology

authors： Luks AM,Levett D,Martin DS,Goss CH,Mitchell K,Fernandez BO,Feelisch M,Grocott MP,Swenson ER,Caudwell Xtreme Everest Investigators.

更新日期：2017-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The central question of this study was to investigate the interaction of mild exposures to O2 and CO2 on chemoreflex control of SNA and the modulation of lung volume and respiratory phase on this interaction. What is the main finding and its importance? We demons...

journal_title：Experimental physiology

authors： Jouett NP,Watenpaugh DE,Dunlap ME,Smith ML

更新日期：2015-09-01 00:00:00

abstract：:Arterial pressure is regulated over long periods of time by neural, hormonal and local control mechanisms, which ultimately determine the total blood volume and how it is distributed between the various vascular compartments of the circulation. A full understanding of the complex interplay of these mechanisms can be g...

journal_title：Experimental physiology

authors： Osborn JW,Averina VA,Fink GD

更新日期：2009-04-01 00:00:00

abstract：:The purpose of this study was to compare the kinetics of estimated capillary blood flow (Qcap) to those of femoral artery blood flow (QFA) and estimated muscle oxygen uptake (VO2m). Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee exten...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2006-07-01 00:00:00

abstract：:Moderate-intensity endurance exercise training improves vascular endothelial vasomotor function; however, the impact of high-intensity exercise training has been equivocal. Thus, the effect of the physiological stress of the exercise remains poorly understood. Furthermore, enhanced vascular repair mediated by circulat...

journal_title：Experimental physiology

authors： Rakobowchuk M,Harris E,Taylor A,Baliga V,Cubbon RM,Rossiter HB,Birch KM

更新日期：2012-03-01 00:00:00

abstract：:Three experiments were performed to see whether cardiac neurons contribute to the intrinsic control of heart rate in right atria of adult rats. The intrinsic heart rate response (IRR) was examined by raising right atrial pressure from 2 to 8 mmHg for 3 min. In isolated preparations of the right atrium, the IRR was not...

journal_title：Experimental physiology

authors： Wilson SJ,Bolter CP

更新日期：2002-11-01 00:00:00

abstract：:Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa. Intestinal reelin and Dab1 mRNA levels were maximal in the early stages of life, reaching adult levels in 1-month-...

journal_title：Experimental physiology

authors： García-Miranda P,Peral MJ,Ilundain AA

更新日期：2010-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Does 14 days of live-high, train-low simulated altitude alter an individual's metabolomic/metabolic profile? What is the main finding and its importance? This study demonstrated that ∼200 h of moderate simulated altitude exposure resulted in greater variance in m...

journal_title：Experimental physiology

authors： Lawler NG,Abbiss CR,Gummer JPA,Broadhurst DI,Govus AD,Fairchild TJ,Thompson KG,Garvican-Lewis LA,Gore CJ,Maker GL,Trengove RD,Peiffer JJ

更新日期：2019-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a family history of hypertension. What is the main f...

journal_title：Experimental physiology

authors： Matthews EL,Greaney JL,Wenner MM

更新日期：2017-09-01 00:00:00

abstract：:Dipeptidylpeptidase IV (DPP IV) activity has been shown cytochemically to decrease significantly in enterocytes of children suffering from coeliac disease. This decrease is due to a halving of the time available for enterocytes to express DPP IV in their brush-border membranes during development. This effect is compar...

journal_title：Experimental physiology

authors： Smith MW,Phillips AD

更新日期：1990-07-01 00:00:00

abstract：:Sodium appetite, the behavioural drive to ingest salt, is stimulated by prolonged physiological sodium deficiency in many animal species. The same neural mechanisms that are responsible for sodium appetite in laboratory animals may influence human behaviour as well, with particular relevance to the dietary salt intake...

journal_title：Experimental physiology

authors： Geerling JC,Loewy AD

更新日期：2008-02-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review is principally concerned with results from studies of the pulmonary vasculature in humans, particularly in relation to hypoxia and rare diseases that affect oxygen sensing. What advances does it highlight? This review highlights the degree to which the hypoxia-...

journal_title：Experimental physiology

authors： Frise MC,Robbins PA

更新日期：2015-11-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Dexmedetomidine has a capacity for sedation, anti-anxiety and analgesia with minimal suppression of respiratory function; what is its role in neuropathic pain and what is the involvement of miRNAs? What is the main finding and its importance? Dexmedetomidine atte...

journal_title：Experimental physiology

authors： Zhang W,Yu T,Cui X,Yu H,Li X

更新日期：2020-09-01 00:00:00

abstract：:A stress protocol--6 h of daily immobilization--was applied throughout male rat sexual development. Immobilization caused a small reduction in food intake and body weight gain whereas pair-fed animals had a marginal decrease only in body weight gain. Stress, confirmed by increased plasma adrenocorticotrophic hormone (...

journal_title：Experimental physiology

authors： Almeida SA,Anselmo-Franci JA,Rosa e Silva AA,Carvalho TL

更新日期：1998-09-01 00:00:00

abstract：:In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...

journal_title：Experimental physiology

authors： Hill-Venning C,Cottrell GA

更新日期：1992-11-01 00:00:00

abstract：:The neurohypophysial hormone vasopressin contributes to control of urine output and, while urine flow shows a clear daily rhythm, there has been debate as to whether this is true of neurohypophysial hormones. A study was performed on fifteen adult males, with a mean age of 25 years, over a 24 h period, nine blood samp...

journal_title：Experimental physiology

authors： Forsling ML,Montgomery H,Halpin D,Windle RJ,Treacher DF

更新日期：1998-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Pregnancy requires a robust plasma volume expansion driven by renal sodium retention. In the late-pregnant kidney, the aldosterone-responsive epithelial Na(+) channel is increased, whereas the sodium-chloride cotransporter is decreased. Pendrin has been shown to ...

journal_title：Experimental physiology

authors： West CA,Verlander JW,Wall SM,Baylis C

更新日期：2015-10-01 00:00:00

abstract：:Uterine and umbilical blood flows were measured in pregnant sheep (125-142 days gestation) under normothermic and hyperthermic conditions using the Fick principle with [14C]antipyrine as the indicator. Exposure of the sheep to an ambient temperature of 43 +/- 1 degrees C (25-30% relative humidity) for 8 h increased ma...

journal_title：Experimental physiology

authors： Andrianakis P,Walker D

更新日期：1994-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? The aim was to determine the effect of mid-portion Achilles tendinopathy (MAT) on free Achilles tendon three-dimensional morphology and volume at rest and under load in people with unilateral MAT. What is the main finding and its importance? Tendinopathic tendon ...

journal_title：Experimental physiology

authors： Nuri L,Obst SJ,Newsham-West R,Barrett RS

更新日期：2018-03-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This article describes the contribution of oxidative stress and pro-inflammatory cytokines to the enhanced carotid body chemosensory responsiveness to the hypoxia and systemic hypertension induced by chronic intermittent hypoxia. What advances does it highlight? Chronic in...

journal_title：Experimental physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2015-02-01 00:00:00

abstract：:The present study was designed to investigate the renal responses to hypotensive haemorrhage early in life and the role of renal sympathetic nerves in modulating these renal responses. To this end, experiments were carried out in conscious, chronically instrumented lambs with either intact renal nerves (n = 7, Intact)...

journal_title：Experimental physiology

authors： Smith FG

更新日期：2002-09-01 00:00:00

abstract：NEW FINDINGS:What is the topic of this review? This review covers recent evidence highlighting the crucial pathophysiological roles and molecular mechanisms of the bone morphogenetic protein (BMP) signalling pathway during the progression of pulmonary hypertension (PH) and discusses targeting of BMP signalling as a new...

journal_title：Experimental physiology

authors： Yang K,Wang J,Lu W

更新日期：2017-09-01 00:00:00

abstract：:This investigation was designed to determine the participation of the vagus nerve and muscarinic receptors in the remote ischaemic preconditioning (rIPC) mechanism. New Zealand rabbits were anaesthetized, and the femoral artery was dissected. After 30 min of monitoring, the hearts were isolated and subjected to 30 min...

journal_title：Experimental physiology

authors： Donato M,Buchholz B,Rodríguez M,Pérez V,Inserte J,García-Dorado D,Gelpi RJ

更新日期：2013-02-01 00:00:00

abstract：:The aim of this study was to evaluate whether long-term administration of L-arginine, a physiological substrate for the production of nitric oxide, improved blood pressure, heart rate, cardiac hypertrophy and particularly structural changes in the coronary and carotid artery of spontaneously hypertensive rats (SHR). T...

journal_title：Experimental physiology

authors： Kristek F

更新日期：1998-09-01 00:00:00

abstract：:The study examined the effect of salt-induced hypertension on vascular relaxation in response to magnesium sulphate during pregnancy. Pregnant Wistar rats were fed for 6 weeks on a diet containing 0.3% (control) and 8.0% (test) sodium chloride. Aortic rings were then removed and contracted with 10(-7) M phenylephrine ...

journal_title：Experimental physiology

authors： Aloamaka CP,Ezimokhai M,Osman NA,Morrison J

更新日期：1995-01-01 00:00:00

abstract：:We compared the effect of age- and sex-related differences in haemodynamics, blood volume (BV) and left ventricular (LV) size and mass on resting muscle sympathetic nerve activity (MSNA) in healthy, normotensive adults. Twenty young men (19-47 years old) and 20 young women (21-46 years old) as well as 15 older men (62...

journal_title：Experimental physiology

authors： Best SA,Okada Y,Galbreath MM,Jarvis SS,Bivens TB,Adams-Huet B,Fu Q

更新日期：2014-06-01 00:00:00

abstract：:The renin-angiotensin system is activated in the early phase of two-kidney, one-clip (2K-1C) hypertension. The paraventricular nucleus (PVN) integrates inputs regulating sympathetic outflow. The PVN receives inputs from plasma angiotensin II via projections from circumventricular organs and from renal afferent nerves ...

journal_title：Experimental physiology

authors： Rossi NF,Maliszewska-Scislo M,Chen H,Black SM,Sharma S,Ravikov R,Augustyniak RA

更新日期：2010-08-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We examined whether the macrophage-synthesized antioxidant 7,8-dihydroneopterin was elevated in Duchenne muscular dystrophy (DMD) patients. We then examined whether 7,8-dihydroneopterin could protect dystrophic skeletal mouse muscle from eccentric contraction-ind...

journal_title：Experimental physiology

authors： Lindsay A,Schmiechen A,Chamberlain CM,Ervasti JM,Lowe DA

更新日期：2018-07-01 00:00:00