Abstract:
:The properties of two types of calcium current (ICa(T) and ICa(L)) and their relationship with contraction were studied in isolated frog atrial trabeculae using the double mannitol gap technique. In Ringer solution containing TTX the calcium currents observed are similar to the ICa(T) and ICa(L) found in single frog atrial cells. The results obtained by using inorganic calcium channel blockers have shown that the phasic contraction appears only when ICa(T) and ICa(L) are simultaneously present. It is proposed that ICa(T) loads the sarcoplasmic reticulum (SR) while ICa(L) triggers Ca2+ release from the SR.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Badaoui A,Léoty Cdoi
10.1113/expphysiol.1994.sp003812subject
Has Abstractpub_date
1994-09-01 00:00:00pages
839-50issue
5eissn
0958-0670issn
1469-445Xjournal_volume
79pub_type
杂志文章abstract::The effects of hypotonic solutions on intracellular Ca2+ were determined on primary cultures of human detrusor smooth muscle cells. In the presence of external Ca2+, changing from a solution containing 290 mosmol l-1 to one containing 240 mosmol l-1 (80% normal tonicity) activated a rise in intracellular Ca2+. If the ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004056
更新日期:1997-07-01 00:00:00
abstract::Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2005.031708
更新日期:2006-01-01 00:00:00
abstract::A video-laryngoscopic method, implemented with an algorithm for the correction of the deformation inherent in the endoscope optical system, has been used to measure the dorsoventral diameter (Drg) and the cross-sectional area (CSArg) of the rima glottidis in five healthy workhorses during conscious breathing at rest. ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Is lower body negative pressure a useful surrogate to study white blood cell responses to haemorrhage in humans? What is the main finding and its importance? We found that lower body negative pressure appears to be a useful surrogate to study the early white bloo...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/EP085952
更新日期:2016-10-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Non-invasive muscle function tests have not been validated for use in the study of muscle performance in high-fat-fed mice. What is the main finding and its importance? This study shows that grip strength, hang wire and four-limb hanging tests are able to discrim...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086328
更新日期:2017-07-01 00:00:00
abstract::The aims of this study were: (1) to determine the within-subject, between-day variability in end-tidal P(CO2) (P(ET,CO2)); (2) to determine whether the within-subject, between-day variability in P(ET,CO2) was caused by variations in metabolic acid-base status; and (3) to determine whether between-subject variations in...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:10.1113/eph8802585
更新日期:2003-09-01 00:00:00
abstract::Experiments were performed to investigate, in the normal and acutely inflamed rabbit knee joint, the role of prostaglandins in the regulation of joint blood flow, measured by laser Doppler flowmetry, as well as their modulation of sympathetic vasoconstriction. Close intra-arterial injection of prostaglandin E2 (PGE2) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1994.sp003745
更新日期:1994-01-01 00:00:00
abstract::It is unclear whether cardiac hypertrophy and hypertrophy-related pathways will be induced by long-term intermittent hypoxia. Thirty-six Sprague-Dawley rats were randomly assigned into three groups: normoxia, and long-term intermittent hypoxia (12% O(2), 8 h per day) for 4 weeks (4WLTIH) or for 8 weeks (8WLTIH). Myoca...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.036590
更新日期:2007-03-01 00:00:00
abstract::The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2005.032037
更新日期:2006-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Impairment and subsequent improvement in cerebral oxygenation during acute and prolonged exposure to high altitude affect exercise performance. This study innovates by investigating the effect of acute and prolonged high-altitude exposure on cerebral haemodynamic...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088354
更新日期:2021-01-01 00:00:00
abstract::Changes in tension of slow motor units in the medial gastrocnemius muscle of the rat were measured and compared in three fatigue tests, each of 4 min duration. In one of these tests motor unit tetani were evoked by repeated trains of stimuli of the standard frequency, 40 Hz, while in other tests frequencies of 20 and ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003907
更新日期:1995-11-01 00:00:00
abstract::Measurements of intracellular calcium (Ca2+i) and sodium (Na+i) have been made in single smooth muscle cells in confluent cultures of the A7r5 cell line using the Ca(2+)- and Na(+)-sensitive dyes Fura-2 and sodium-binding benzofuran isophthalate (SBFI). Reversal of the Na+ gradient in control cells results in a small ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003625
更新日期:1992-07-01 00:00:00
abstract::A considerable body of evidence indicates that the intracellular chloride concentration ([Cl-]i) is an important regulatory signal in epithelial ion transport. [Cl-]i regulates the open channel probability of sodium and chloride channels, the rate of chloride channel recycling to the apical membrane, cell volume homeo...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2005.031823
更新日期:2006-01-01 00:00:00
abstract::The aim of the present work was to investigate the role of the serotoninergic system in the control of sodium appetite of hypothyroid rats (HTR) by administering drugs that affect the serotoninergic activity, and to compare the same homeostatic behaviour in euthyroid rats (ETR) also given these drugs. Fenfluramine (FE...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8802457
更新日期:2003-03-01 00:00:00
abstract::Branched fibres are a well-documented phenomenon of regenerating skeletal muscle. They are found in the muscles of boys with Duchenne muscular dystrophy (DMD), a severe condition of progressive muscle wasting caused by an absence of the sarcolemmal protein dystrophin, and in the muscles of the mdx mouse, an animal mod...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2010.056713
更新日期:2011-06-01 00:00:00
abstract::Endothelium-dependent relaxation in response to histamine and ACh has been studied on precontracted aortic rings from control and salt-loaded Sprague-Dawley rats. Both ACh and histamine caused relaxation of the noradrenaline-induced precontraction only in the presence of the endothelium. The relaxation response to ACh...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003475
更新日期:1991-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Is mesenchymal stem cell-conditioned medium capable of improving the pathological alterations of ovalbumin-induced asthma in mice? What is the main finding and its importance? Our study indicated that human amniotic membrane mesenchymal stem cell-conditioned medi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088911
更新日期:2020-12-01 00:00:00
abstract::Metabolic stress is believed to constitute an important signal for training-induced adjustments of gene expression and oxidative capacity in skeletal muscle. We hypothesized that the effects of endurance training on expression of muscle-relevant transcripts and ultrastructure would be specifically modified by a hypoxi...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.051029
更新日期:2010-06-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do obesity-specific factors affect skeletal muscle performance in older individuals? What is the main finding and its importance? Older obese women have a larger quadriceps femoris size but develop lower tension per unit of skeletal muscle than their normal-weigh...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085273
更新日期:2015-10-01 00:00:00
abstract::Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When it is administered orally to suckling rats, it induces maturation of the intestinal tract (liver, pancreas and small intestine). Here we show that this polyamine is able to induce precocious intestinal and splenic develo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8702277
更新日期:2002-01-01 00:00:00
abstract::This work was undertaken to study the effect of pectin feeding on the expression level, cellular localization and functional activity of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of rats. The results indicated that MCT1 protein level was significantly increased along the entire length of the g...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.046797
更新日期:2009-04-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? This study was designed to investigate the molecular mechanism and biological roles of long non-coding RNA activated by transforming growth factor-β (lncRNA ATB) in the progression of cervical cancer. What is the main finding and its importance? Our study provide...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087656
更新日期:2019-06-01 00:00:00
abstract::Transport of a number of dipolar amino acids (and the orally active antibiotic D-cycloserine) across the apical membrane of human intestinal epithelial (Caco-2) cell monolayers is mediated by a Na+-independent, pH-dependent transport mechanism. Relatively little is known about the mode of action of this transport syst...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:NEW FINDINGS:What is the topic of this review? The manuscript collectively combines the experimental observations from >100 publications focusing on the regulation of cerebral blood flow and metabolism during exercise from 1945 to the present day. What advances does it highlight? This article highlights the importance ...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/EP086249
更新日期:2017-11-01 00:00:00
abstract::Indirect evidence supporting a solute-coupled liquid absorption from the pleural space of rabbits has recently been provided; moreover, the beta 2-adrenoceptor agonist terbutaline has been found to increase this absorption. In this study the effect of adrenaline and alpha-adrenoceptor agonists on net rate of liquid ab...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1997.sp004043
更新日期:1997-05-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Does short-term heat acclimation enhance whole-body evaporative heat loss and augment nitric oxide synthase (NOS)-dependent cutaneous vasodilatation and NOS- and cyclooxygenase (COX)-dependent sweating, in exercising older men? What is the main finding and its im...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP089025
更新日期:2020-12-21 00:00:00
abstract::5-[5-(2-Nitrophenyl) furfuryliodine]-1,3-diphenyl-2-thiobarbituric acid (UCF-101) is a protease inhibitor which was reported to protect against ischaemic heart damage and apoptosis. This study evaluated the impact of UCF-101 on steptozotocin (STZ)-induced diabetic cardiomyocyte dysfunction. Adult FVB mice were made di...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.049189
更新日期:2009-09-01 00:00:00
abstract::The results of this investigation demonstrate, using a position matching paradigm, that the ability of subjects to detect changes in the position of the proximal interphalangeal joint is impaired in patients with rheumatoid arthritis affecting this joint. In this group there is a systematic flexion bias in position ju...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1992.sp003633
更新日期:1992-09-01 00:00:00
abstract::Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is likely to be mediated, at least in part, by an elevation of ongoing sympathetic nerve activity (SNA). However, the contribution of SNA relative to non-neural mechanisms in mediating Ang II-induced hypertension is an area of i...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2009.047399
更新日期:2010-05-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Glucose is the dominant energy source for the brain. However, little is known about how glucose metabolism impacts the coordination of network activity in the brain in healthy adults. What is the main finding and its importance? We demonstrate that both alpha osc...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP089211
更新日期:2021-01-28 00:00:00