Abstract:
:One of the most basic computational elements within a circuit is the synapse across which signals are transferred. Here we summarize some experimental strategies that allow the synaptic basis of circuit function to be studied through imaging. The two most promising approaches available currently are pHluorin-based reporters of synaptic vesicle fusion and genetically encoded calcium indicators localized to presynaptic terminals. Other potential approaches include the optical sensing of local voltage changes or of neurotransmitter substances, but the spatial and temporal sensitivity of the current reporters would need to be improved.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Dreosti E,Lagnado Ldoi
10.1113/expphysiol.2009.051953subject
Has Abstractpub_date
2011-01-01 00:00:00pages
4-12issue
1eissn
0958-0670issn
1469-445Xpii
expphysiol.2009.051953journal_volume
96pub_type
杂志文章,评审abstract::The effects of the bacterial toxin Escherichia coli STa on electrogenic secretion in proximal, mid and distal rat colon were examined in vitro using the short-circuit current (Isc) as an index of secretion. All areas showed toxin-elevated Isc which was reduced by bumetanide. The proximal colon was the most sensitive (...
journal_title:Experimental physiology
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journal_title:Experimental physiology
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更新日期:1995-05-01 00:00:00
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abstract::It is now well accepted that the sympathetic nervous system responds to specific afferent stimuli in a unique non-uniform fashion. The means by which the brain transforms the signals from a single type of receptor into an appropriate differential sympathetic output is discussed in this brief review. The detection of a...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
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更新日期:2005-03-01 00:00:00
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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更新日期:2010-01-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP086621
更新日期:2018-01-01 00:00:00
abstract::Experiments were carried out to examine the perceived position of the human index finger about the proximal interphalangeal joint. In protocol I, the finger was moved from an intermediate position at velocities ranging from 200 deg/min to 2 deg/min, then held still at one of three positions. The subject's task was vis...
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更新日期:2018-09-01 00:00:00
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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