Abstract:
NEW FINDINGS:What is the central question of this study? What are the characteristics of the NK cell response following acute moderate-intensity aerobic exercise in prostate cancer survivors and is there a relationship between stress hormones and NK cell mobilization? What is the main finding and its importance? NK cell numbers and proportions changed similarly between prostate cancer survivors and controls following acute exercise. Consecutive training sessions can likely be used without adverse effects on the immune system during prostate cancer treatment. ABSTRACT:Prostate cancer treatment affects multiple physiological systems, although the immune response during exercise has been minimally investigated. The objective was to characterize the natural killer (NK) cell response following acute exercise in prostate cancer survivors. Prostate cancer survivors on androgen deprivation therapy (ADT) and those without (PCa) along with non-cancer controls (CON) completed a moderate intensity cycling bout. NK cells were phenotyped before and 0, 2 and 24 h after acute exercise using flow cytometry. CD56 total NK cell frequency increased by 6.2% at 0 h (P < 0.001) and decreased by 2.5% at 2 h (P < 0.01) with similar findings in CD56dim cells. NK cell counts also exhibited a biphasic response. Independent of exercise, ADT had intracellular interferon γ (IFNγ) expression that was nearly twofold higher than CON (P < 0.01). PCa perforin expression was reduced by 11.4% (P < 0.05), suggesting these cells may be more prone to degranulation. CD57- NK cells demonstrated increased perforin and IFNγ frequencies after exercise with no change within the CD57+ populations. All NK and leukocyte populations returned to baseline by 24 h. NK cell mobilization and egress with acute exercise appear normal, as cell counts and frequencies in prostate cancer survivors change similarly to CON. However, lower perforin proportions (PCa) and higher IFNγ expression (ADT) may alter NK cytotoxicity and require further investigation. The return of NK cell proportions to resting levels overnight suggests that consecutive training sessions can be used without adverse effects on the immune system during prostate cancer treatment.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Hanson ED,Sakkal S,Que S,Cho E,Spielmann G,Kadife E,Violet JA,Battaglini CL,Stoner L,Bartlett DB,McConell GK,Hayes Adoi
10.1113/EP088627subject
Has Abstractpub_date
2020-09-01 00:00:00pages
1524-1539issue
9eissn
0958-0670issn
1469-445Xjournal_volume
105pub_type
杂志文章abstract:NEW FINDINGS:What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months h...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087198
更新日期:2018-12-01 00:00:00
abstract::The present study was designed to investigate the renal responses to hypotensive haemorrhage early in life and the role of renal sympathetic nerves in modulating these renal responses. To this end, experiments were carried out in conscious, chronically instrumented lambs with either intact renal nerves (n = 7, Intact)...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8702434
更新日期:2002-09-01 00:00:00
abstract::The present work reports the effect of pHo on pHi and Na(+)-H+ exchanger activity. Intracellular pH tended to follow pHo, but the proton distribution across the cell membrane is not at electrochemical equilibrium. Removal of external Na+ acidified the cells by both reversing the direction of the Na(+)-H+ exchanger and...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003897
更新日期:1995-11-01 00:00:00
abstract::What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would sho...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP085716
更新日期:2016-07-01 00:00:00
abstract::All eukaryotic cells utilize oxidative phosphorylation to maintain their high-energy phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and cell survival is threatened when cells are deprived of O(2). Consequently, all cells have the ability to sense O(2), and to activate adaptive proce...
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2006.033506
更新日期:2006-09-01 00:00:00
abstract::In the present study, we tested the hypothesis that chronic intermittent hypoxia (CIH) produces changes in the autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed to 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They wer...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.034868
更新日期:2006-11-01 00:00:00
abstract::In pentobarbitione-anaesthetized rats the parasympathetic auriculotemporal nerve of the parotid gland was continuously stimulated at supramaximal voltage and at maximal frequency (40 Hz) for salivary secretion. The animals were pretreated with phentolamine and propranolol (2 mg kg-1 i.p. of each) and, in some groups, ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1996.sp003994
更新日期:1996-11-01 00:00:00
abstract::The effects of the bacterial toxin Escherichia coli STa on electrogenic secretion in proximal, mid and distal rat colon were examined in vitro using the short-circuit current (Isc) as an index of secretion. All areas showed toxin-elevated Isc which was reduced by bumetanide. The proximal colon was the most sensitive (...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003561
更新日期:1991-11-01 00:00:00
abstract::We estimated the transfer function of autonomic heart rate (HR) control by using random binary sympathetic or vagal nerve stimulation in anaesthetized rats. The transfer function from sympathetic stimulation to HR response approximated a second-order, low-pass filter with a lag time (gain, 4.29 +/- 1.55 beats min(1) H...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2010.053090
更新日期:2010-09-01 00:00:00
abstract::Plasticity of insulin secretion is essential to maintain the action of insulin during insulin resistance and to prevent diabetes. Investigation of the plasticity of insulin secretion and its regulation is challenging, and the objective of this study was to develop a novel large-animal-based model. The effect of chroni...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2011.063560
更新日期:2012-05-01 00:00:00
abstract::Rats were fed a liquid diet with the aim of decreasing nervous reflex activity in the parotid glands. In rats killed after 21 days on this diet the glands were atrophied and the total amounts of the neuropeptides, substance P, vasoactive intestinal peptide and calcitonin gene-related peptide, were lower than in contro...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003435
更新日期:1990-07-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What are the molecular underpinnings of seasonal metabolic plasticity during spring and autumn migrations in songbirds? What is the main finding and its importance? We report differences in mRNA levels of genes involved in the regulation of glucose and fat metabo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087974
更新日期:2019-12-01 00:00:00
abstract::It is unclear whether cardiac hypertrophy and hypertrophy-related pathways will be induced by long-term intermittent hypoxia. Thirty-six Sprague-Dawley rats were randomly assigned into three groups: normoxia, and long-term intermittent hypoxia (12% O(2), 8 h per day) for 4 weeks (4WLTIH) or for 8 weeks (8WLTIH). Myoca...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.036590
更新日期:2007-03-01 00:00:00
abstract::The vascular actions of insulin are complex, because it can stimulate both nitric oxide-mediated dilatation and endothelin (ET)-1-mediated constriction. We examined vasoreactivity to insulin in isolated feed arteries of the gastrocnemius (GFA) and soleus muscles (SFA) of 32-week-old Long-Evans Tokushima Otsuka (LETO) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2013.074047
更新日期:2014-01-01 00:00:00
abstract::The effects of exogenous arginine vasotocin (AVT), isotocin (IT) and melatonin on the blood pressure of conscious Atlantic cod (Gadus morhua) were examined. Ventral aortic blood pressure (PVA) was recorded from a cannula inserted into the afferent branchial artery of the third gill arch. Dorsal aortic blood pressure (...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1998.sp004161
更新日期:1998-11-01 00:00:00
abstract::Appreciation for the role of aldosterone and mineralocorticoid receptors in cardiovascular disease is accelerating rapidly. Recent experimental work has unveiled a strong relationship between brain mineralocorticoid receptors and sympathetic drive, an important determinant of outcome in heart failure and hypertension....
journal_title:Experimental physiology
pub_type: 杂志文章,评审
doi:10.1113/expphysiol.2008.045948
更新日期:2010-01-01 00:00:00
abstract::Single cells from the rabbit pulmonary artery were isolated using a new and convenient procedure. Strips of muscle were incubated overnight in papain at 6 degrees C and dispersed the following morning after warming the tissue for 10 min. This method consistently produced a high yield of relaxed cells, which reversibly...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003535
更新日期:1991-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do individuals with a patent foramen ovale (PFO+ ) have a larger alveolar-to-arterial difference in P O 2 ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088750
更新日期:2020-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? What factors influence the onset and magnitude of activation of the neck inspiratory muscles during inspiration? What is the main finding and its importance? Recruitment of the sternocleidomastoid and scalene muscles during inspiration, measured by means of surfa...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP087247
更新日期:2019-04-01 00:00:00
abstract::Oxidants have been suggested to enhance contractile function in unfatigued muscle. In this study we aimed to determine the effect of oxidants on "chemically skinned" diaphragm muscle fibre bundles. The sarcoplasmic reticulum and contractile proteins were exposed to superoxide anions (O2-) and hydrogen peroxide (H2O2) ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/eph8602109
更新日期:2001-03-01 00:00:00
abstract::It is commonly stated that smell elicits a parotid salivary reflex in humans. However, this assumption seems to be supported only by experiments in which either a lemon or an irritating odour has been used as the primary stimulus. In this study six pleasant odours, chocolate, vanilla, peppermint, beef, tomato and lemo...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1991.sp003502
更新日期:1991-05-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? There is an ethical imperative to optimize analgesia protocols for laboratory animals, but this is impeded by our inability to recognize pain reliably. We examined whether the Mouse Grimace Scale (MGS) provides benefits over a standard welfare scoring system for ...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.083139
更新日期:2015-02-01 00:00:00
abstract::Intestinal secretion is enhanced by starvation in rats. The rectum from fed and 3-day-starved rats generates a basal electrogenic ion transfer (short-circuit current) in vitro which is mainly electrogenic Na+ absorption (amiloride-sensitive, 66-71%) with a small component of electrogenic chloride secretion (furosemide...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003438
更新日期:1990-07-01 00:00:00
abstract::Methyl CpG binding protein-2 (MECP2) is a chromatin-remodelling factor with a dual role in gene expression. Evidence from patients carrying MECP2 mutations and from transgenic mouse models demonstrates that this protein is involved in the control of body weight. However, the mechanism for this has not been fully eluci...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2014.079798
更新日期:2014-09-01 00:00:00
abstract::We recently reported that a higher percentage of type I fibres in vastus lateralis and a greater peak oxygen uptake (O2) were associated with a greater initial rise in O2 (O2 /W, where W is work rate) following the onset of heavy constant power output exercise (above the lactate threshold, LT). It was unclear if these...
journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? The role of the cerebral haemodynamic response to either normobaric or hypobaric hypoxia in people susceptible to acute mountain sickness (AMS) is still under debate. Prefrontal cortex near-infrared spectroscopy-derived parameters were monitored in normobaric hyp...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088515
更新日期:2021-01-01 00:00:00
abstract::Exercise induces a marked increase in interleukin-8 (IL-8) mRNA and protein expression within skeletal muscle fibres. Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif. CXC chemokines with ELR motifs are potent angiogenic factors in vivo, and IL-8 has been shown to act as an a...
journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
doi:10.1113/expphysiol.2006.034769
更新日期:2007-01-01 00:00:00
abstract::The nucleus tractus solitarii (NTS) is a key central link in control of multiple homeostatic reflexes. A number of studies have demonstrated that exogenous and endogenous nitric oxide (NO) within NTS regulates visceral function, but further understanding of the role of NO in the NTS is hampered by the lack of informat...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.2006.036103
更新日期:2007-03-01 00:00:00
abstract::Gastric motility was recorded from ferrets chronically prepared with an antral strain gauge. In fasted animals, antral motility showed cycles of activity and quiescence typical of the migrating motor complex (MMC) with a period of 44.7 +/- 6.1 min (n = 4). Anaesthesia with pentobarbitone sodium (50 mg/kg) disrupted th...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1990.sp003448
更新日期:1990-09-01 00:00:00
abstract:NEW FINDINGS:What is the central question of this study? Do changes in levels of angiogenesis-related mediators [vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor-κB (NF-κB)] in the sciatic nerve mediate diabetic neuropathy in the streptozotocin-induced type 1 diabetic male rat?...
journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/EP088069
更新日期:2020-05-01 00:00:00