Role of prostaglandins in regulation of blood flow and modulation of sympathetic vasoconstriction in normal and acutely inflamed rabbit knee joints.

abstract：NEW FINDINGS:What is the topic of this review? The manuscript collectively combines the experimental observations from >100 publications focusing on the regulation of cerebral blood flow and metabolism during exercise from 1945 to the present day. What advances does it highlight? This article highlights the importance ...

journal_title：Experimental physiology

authors： Smith KJ,Ainslie PN

更新日期：2017-11-01 00:00:00

abstract：:It is unknown whether changes in corticomotor excitability follow prolonged exercise in healthy humans. Furthermore, the role of supraspinal fatigue in decrements of force production and voluntary activation following prolonged exercise has not been established. This study investigated peripheral and central fatigue a...

journal_title：Experimental physiology

authors： Ross EZ,Middleton N,Shave R,George K,Nowicky A

更新日期：2007-03-01 00:00:00

abstract：:Using real-time two-photon laser scanning microscopy, we have demonstrated that lysophosphatidic acid (LPA), a bioactive lipid mediator, causes shear stress-dependent oscillatory local increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fluo-4-loaded endothelial cells of isolated mouse aortic strips in sit...

journal_title：Experimental physiology

authors： Ohata H,Yamada H,Momose K

更新日期：2011-04-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Clinical studies suggest that obesity 'protects' against osteoporosis. However, these studies used only bone densitometry and assessed only one bone site, which is insufficient to enable conclusions to be drawn about the response of the whole skeleton. Furthermor...

journal_title：Experimental physiology

authors： Lacerda DR,Serakides R,de Melo Ocarino N,Ferreira AV,Moraes MM,Boeloni JN,Silva JF,de Oliveira MC,de Barcellos LA,Rodrigues LO,Soares DD

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin sub...

journal_title：Experimental physiology

authors： Bányász T,Kovács T

更新日期：1998-01-01 00:00:00

abstract：:The effect of resistance training on arterial stiffening is controversial. We tested the hypothesis that resistance training would not alter central arterial compliance. Young healthy men (age, 23 +/- 3.9 (mean +/- s.e.m.) years; n = 28,) were whole-body resistance trained five times a week for 12 weeks, using a rotat...

journal_title：Experimental physiology

authors： Rakobowchuk M,McGowan CL,de Groot PC,Bruinsma D,Hartman JW,Phillips SM,MacDonald MJ

更新日期：2005-07-01 00:00:00

abstract：:After food is ingested, nutrients pass through the gastrointestinal tract, stimulating the release of a range of peptide hormones. Among their many local, central and peripheral actions, these hormones act to mediate glucose metabolism and satiety. Indeed, it is the modification of gut hormone secretion that is consid...

journal_title：Experimental physiology

authors： Parker HE,Gribble FM,Reimann F

更新日期：2014-09-01 00:00:00

abstract：:This study investigated the role of nitric oxide (NO) and superoxide anions in modulating the renal nerve-dependent increases in proximal tubular fluid reabsorption (Jva). Renal nerve stimulation at 0.75 and 1.0 Hz (15 V, 0.2 ms) in anaesthetized Wistar rats had no effect on glomerular filtration rate but decreased ur...

journal_title：Experimental physiology

authors： Wu XC,Johns EJ

更新日期：2004-05-01 00:00:00

abstract：:Despite its critical role in restoring cardiac rhythm and thus in saving human life, cardiac defibrillation remains poorly understood. Further mechanistic inquiry is hampered by the inability of presently available experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth...

journal_title：Experimental physiology

authors： Trayanova N

更新日期：2006-03-01 00:00:00

abstract：:Hypertension caused by chronic infusion of angiotensin II (Ang II) in experimental animals is likely to be mediated, at least in part, by an elevation of ongoing sympathetic nerve activity (SNA). However, the contribution of SNA relative to non-neural mechanisms in mediating Ang II-induced hypertension is an area of i...

journal_title：Experimental physiology

authors： Toney GM,Pedrino GR,Fink GD,Osborn JW

更新日期：2010-05-01 00:00:00

abstract：:Mechanical properties of the vascular smooth muscle from normal and dystrophin-deficient (mdx) mice were examined. Changes in resting and developed tensions in response to stretch were recorded in isolated portal vein. The vascular segments were elongated in 5 % increments of the 'in situ' length (Lr) up to 1.30Lr. Th...

journal_title：Experimental physiology

authors： Mancinelli R,Tonali P,Romani R,Tringali A,Vargiu R,AZZENA GB

更新日期：1999-09-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Hypoxic pulmonary vasoconstriction has never been characterized in isolated mouse pulmonary arteries of different generations in detail. What is the main finding and its importance? We found that only small intrapulmonary arteries (80-200 μm in diameter) exhibit ...

journal_title：Experimental physiology

authors： Strielkov I,Krause NC,Sommer N,Schermuly RT,Ghofrani HA,Grimminger F,Gudermann T,Dietrich A,Weissmann N

更新日期：2018-09-01 00:00:00

abstract：:In Helix aspersa, activation of the cerebral giant serotonin neurones (GSNs) evokes a biphasic, excitatory synaptic response in the M neurones of the buccal ganglia. Local application of serotonin to the current-clamped M neurones also evokes fast and slow depolarizing responses. The slow response is thought to be dep...

journal_title：Experimental physiology

authors： Hill-Venning C,Cottrell GA

更新日期：1992-11-01 00:00:00

abstract：:Hypoglossal nerve activity (HNA) controls the position and movements of the tongue. In persons with compromised upper airway anatomy, sleep-related hypotonia of the tongue and other pharyngeal muscles causes increased upper airway resistance, or total upper airway obstructions, thus disrupting both sleep and breathing...

journal_title：Experimental physiology

authors： Brandes IF,Stettner GM,Mörschel M,Kubin L,Dutschmann M

更新日期：2011-05-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Compared with Caucasians, African individuals are more susceptible to non-freezing cold injury and experience greater cutaneous vasoconstriction and cooler finger skin temperatures upon hand cooling. We investigated whether the enzyme cyclooxygenase is, in part, ...

journal_title：Experimental physiology

authors： Maley MJ,House JR,Tipton MJ,Eglin CM

更新日期：2017-07-01 00:00:00

abstract：:Progressive asphyxia, produced by a prolonged voluntary breath hold (end-expiratory apnoea), evokes large bursts of muscle sympathetic nerve activity (MSNA). These bursts increase in amplitude until the asphyxic break point is reached, at which point the bursts are inhibited. We tested the hypothesis that lung inflati...

journal_title：Experimental physiology

authors： Seitz MJ,Brown R,Macefield VG

更新日期：2013-02-01 00:00:00

abstract：NEW FINDINGS:What is the central question of the study? What are the effects of age and fitness on the vascular response to acute inflammation in younger and older adults? What is the main finding and its importance? In older adults, cardiorespiratory fitness level has a differential impact on endothelial function afte...

journal_title：Experimental physiology

authors： Schroeder EC,Lane-Cordova AD,Ranadive SM,Baynard T,Fernhall B

更新日期：2018-06-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What mechanisms account for the hypotension observed during chronic elevations in circulating 5-hydroxytryptamine in rats? What is the main finding and its importance? Chronic 5-hydroxytryptamine-induced hypotension requires continued activation of the 5-HT7 rece...

journal_title：Experimental physiology

authors： Seitz BM,Fink GD,Watts SW

更新日期：2020-10-14 00:00:00

abstract：:The results of this investigation demonstrate, using a position matching paradigm, that the ability of subjects to detect changes in the position of the proximal interphalangeal joint is impaired in patients with rheumatoid arthritis affecting this joint. In this group there is a systematic flexion bias in position ju...

journal_title：Experimental physiology

authors： Ferrell WR,Crighton A,Sturrock RD

更新日期：1992-09-01 00:00:00

abstract：:We present a curve-fitting approach that permits quantitative comparisons of fatigue profiles obtained with different stimulation protocols in isolated slow-twitch soleus and fast-twitch extensor digitorum longus (EDL) muscles of mice. Profiles from our usual stimulation protocol (125 Hz for 500 ms, evoked once every ...

journal_title：Experimental physiology

authors： Cairns SP,Robinson DM,Loiselle DS

更新日期：2008-07-01 00:00:00

abstract：:In anaesthetized cats, reflex respiratory responses were evoked by electrically stimulating proximal ends of cut nerves to gastrocnemius-soleus muscles of the left hindlimb. The direction of these responses, in the excitatory or inhibitory sense, depended on the types of afferent fibres stimulated and on the mode of s...

journal_title：Experimental physiology

authors： Decandia M,Orani GP

更新日期：1995-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? What is the nature of slow wave-driven contraction frequency gradients in the small intestine? What is the main finding and its importance? Frequency plateaux are composed of discrete waves of increased interval, each wave associated with a contraction dislocatio...

journal_title：Experimental physiology

authors： Parsons SP,Huizinga JD

更新日期：2018-08-01 00:00:00

abstract：:Beneficial effects of exercise training on the vasculature have been consistently reported in subjects with cardiovascular risk factors or disease, whereas studies in apparently healthy subjects have been less uniform. In this review, we examine evidence pertaining to the impact of exercise training on conduit and res...

journal_title：Experimental physiology

authors： Green DJ,Spence A,Halliwill JR,Cable NT,Thijssen DH

更新日期：2011-02-01 00:00:00

abstract：:Resting heart rate and heart rate variability of 33 postmenopausal women were compared with those of 50 premenopausal women of comparable activity level, none of whom had used hormone replacement therapy. Heart rate was measured as the mean of at least 600 consecutive R-R intervals obtained from electrocardiograph (EC...

journal_title：Experimental physiology

authors： Brockbank CL,Chatterjee F,Bruce SA,Woledge RC

更新日期：2000-05-01 00:00:00

abstract：:A great deal of knowledge exists regarding neural control of myocardial function in the rat. Most of the studies addressing this issue were conducted either under general anaesthesia or in isolated hearts in vitro. Our principal aim was to provide a detailed quantitative description of mechanisms controlling cardiac c...

journal_title：Experimental physiology

authors： Nalivaiko E,Antunes VR,Paton JF

更新日期：2010-01-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? We modelled the alveolar pathway during breath holding on the hypothesis that it follows a hypoventilation loop on the O2 -CO2 diagram. What is the main finding and its importance? Validation of the model was possible within the range of alveolar gas compositions...

journal_title：Experimental physiology

authors： Taboni A,Fagoni N,Fontolliet T,Grasso GS,Moia C,Vinetti G,Ferretti G

更新日期：2020-09-29 00:00:00

abstract：:The inward transport of two purines, adenosine and hypoxanthine, at 37 degrees C by horse erythrocytes was compared. No mediated transport of adenosine was detected in horse erythrocytes, nor was saturable, high-affinity binding of the potent facilitated-diffusion inhibitor nitrobenzylthioinosine demonstrable in horse...

journal_title：Experimental physiology

authors： Jarvis SM,Harris RC

更新日期：1998-03-01 00:00:00

abstract：NEW FINDINGS:What is the central question of this study? Is chemerin, an adipokine implicated in obesity, increased in neonates following in utero cigarette smoke exposure. What is the main finding and its importance? Chemerin mRNA expression was increased and chemerin DNA methylation was decreased in babies born to mo...

journal_title：Experimental physiology

authors： Reynolds LJ,Chavan NR,DeHoff LB,Preston JD,Maddox HF,O'Brien JM,Armstrong DA,Marsit CJ,Pearson KJ

更新日期：2019-01-01 00:00:00

abstract：:Cardiovascular arousal is associated with patterned cortical activity changes. Head-down-tilt bed rest (HDBR) dimishes the baroreflex-mediated cardiac control. The present study tested the hypothesis that HDBR deconditioning would modify the forebrain organization for heart rate (HR) control during baroreflex unloadin...

journal_title：Experimental physiology

authors： Shoemaker JK,Usselman CW,Rothwell A,Wong SW

更新日期：2012-12-01 00:00:00

abstract：:Lateral ventricular volumes were monitored and quantified using accurately registered magnetic resonance images (MRIs) in six healthy individuals 30 min before and up to 4 h after ingestion of a glucose drink. The volume of the lateral ventricles increased by an average (+/- S.E.M.) of 2.4 +/- 0.4% as blood glucose le...

journal_title：Experimental physiology

authors： Puri BK,Lewis HJ,Saeed N,Davey NJ

更新日期：1999-01-01 00:00:00