Abstract:
:Improved understanding of the processes involved in infarct healing is required for identification of novel therapeutic targets to limit infarct expansion and consequent long-term ventricular remodelling after myocardial infarction. Infarct healing can be modelled effectively in murine models of coronary artery ligation. While imaging the murine heart is challenging due to its size and high rate of contraction, advances in preclinical imaging now permit accurate assessment of myocardial structure and function in vivo after myocardial infarction. Furthermore, rapid development of a range of molecular probes for use in a number of imaging modalities allows more detailed in vivo analysis of processes, including inflammation, fibrosis and angiogenesis. Here we consider the practical application of in vivo imaging by magnetic resonance imaging, ultrasound and fluorescence molecular tomography for assessment of infarct healing in the mouse.
journal_name
Exp Physioljournal_title
Experimental physiologyauthors
Gray GA,White CI,Thomson A,Kozak A,Moran C,Jansen MAdoi
10.1113/expphysiol.2012.064741subject
Has Abstractpub_date
2013-03-01 00:00:00pages
606-13issue
3eissn
0958-0670issn
1469-445Xpii
expphysiol.2012.064741journal_volume
98pub_type
杂志文章,评审abstract::Lateral ventricular volumes were monitored and quantified using accurately registered magnetic resonance images (MRIs) in six healthy individuals 30 min before and up to 4 h after ingestion of a glucose drink. The volume of the lateral ventricles increased by an average (+/- S.E.M.) of 2.4 +/- 0.4% as blood glucose le...
journal_title:Experimental physiology
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abstract:NEW FINDINGS:What is the central question of this study? Does sex or neonatal stress affect the expression of pituitary adenylate cyclase-activating peptide or its receptors? What is the main finding and its importance? Neonatal-maternal separation stress has little long-lasting effect on the expression of pituitary ad...
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journal_title:Experimental physiology
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journal_title:Experimental physiology
pub_type: 临床试验,杂志文章
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journal_title:Experimental physiology
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journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
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journal_title:Experimental physiology
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章,随机对照试验
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更新日期:2010-04-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1113/expphysiol.2006.033696
更新日期:2006-09-01 00:00:00
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journal_title:Experimental physiology
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更新日期:1994-07-01 00:00:00
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journal_title:Experimental physiology
pub_type: 杂志文章
doi:10.1113/expphysiol.1995.sp003897
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doi:10.1113/expphysiol.2009.048710
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pub_type: 杂志文章,评审
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journal_title:Experimental physiology
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pub_type: 杂志文章,随机对照试验
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abstract:NEW FINDINGS:What is the topic of this review? We discuss tools available to access genome-wide data sets that harbour cell-specific, brain region-specific and tissue-specific information on exon usage for several species, including humans. In this Review, we demonstrate how to access this information in genome databas...
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journal_title:Experimental physiology
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journal_title:Experimental physiology
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更新日期:1990-07-01 00:00:00
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